Phase 4 N=116 Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements?
Arthropathy of Hip
Primary: Surgical Conditions — 1; 2; 11; 10 Participants
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=1,008 Reevaluation Of Systemic Early Neuromuscular Blockade
Acute Respiratory Distress Syndrome
Primary: Hospital Mortality to Day 90 — 288; 289; 213; 216 Participants — p=0.93
Phase 4 N=100 Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery
Neuromuscular Blockade · Postoperative Complications
Primary: Number of Participants With Postoperative Pulmonary Complications — 8; 8 Participants — p=1.00
Phase 2 N=83 Neuromuscular Blockade for Post-Cardiac Arrest Care
Cardiac Arrest
Primary: Change in Lactate Over 24 Hours — -2.2; -2.3 mmol/L
N/A N=37 Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade.
Intraoperative Complications · Postoperative Complications · Laparoscopy
Primary: Regional Change in Air Content (Delta Z, %) — 14.5; 29.0; 43.3; -14.0 percent change
Phase 4 N=61 Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics
Laparoscopic Renal Surgery · Laparoscopy · Muscle Relaxation
Primary: Thoracopulmonary Compliance — 51.9; 52.3; 34.6; 31.9 ml/cmH2O
Phase 4 N=90 Effect of Neuromuscular Blockade on Operating Conditions and Overall Satisfaction During Spinal Surgery
Neuromuscular Blockade · Surgery · Anesthesia
Primary: Mean Value of Peak Inspiratory Pressure — 18.4; 20.2 cmH2O — p=<0.001
N/A N=32 Neuromuscular Blocking Agents in the Elderly
Elective Surgery
Primary: Onset Time — 135; 90 seconds — p=<0.001
Phase 4 N=60 Comparison of Obturator Nerve Blockade and Neuromuscular Blockade
Cancer of Bladder
Primary: Number of Patients With Incidence of Intraoperative Adductor Spasm — 1; 5 Participants
Phase 4 N=98 Effect of Deep Versus Moderate Neuromuscular Block During Sevoflurane Anesthesia on Intraoperative Surgical Conditions.
Surgical Conditions
Primary: Leiden Surgical Rating Scale — 4.8; 4.8 score on a scale — p=0.94
N/A N=300 The Effect of Age on the Incidence of Postoperative Residual Neuromuscular Blockade
Residual Neuromuscular Blockade in Elderly Patients
Primary: Incidence of Residual Neuromuscular Blockade — 45; 86 participants
Phase 4 N=189 Best Management of Muscle Relaxation- Objective Monitoring
Residual Paralysis, Post Anesthesia
Primary: Incidence of Postoperative Residual Neuromuscular Blockade at Time of Extubation — 0 Participants
Phase 4 N=109 Effect of Deep Neuromuscular Block on Surgical Conditions in Morbidly Obese Patients
Surgical Conditions
Primary: Surgical Rating — 4.2; 4.8 units on a scale — p=0.001
Phase 4 N=108 Neuromuscular Blockade During Transurethral Resection of Bladder Cancer
Neuromuscular Blockade
Primary: Number of Participants Attaining a 5 (Optimal) Surgical Condition Score — 16; 38 Participants
Phase 2 N=49 Neuromuscular Blockade in Patients With Severe Renal Impairment
Neuromuscular Blockade · Renal Impairment
Primary: Time Until Complete Reversal of Neuromuscular Blockade — 14.8; 3.5 Minutes
Phase 4 N=79 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery
Cholecystitis · Endometriosis · Bowel Obstruction
Primary: Peak Airway Pressures — 25.5; 28.3; 28; 30 cm H2O — p=0.01
N/A N=170 Intubating Conditions of Neuromuscular Blockade
Endotracheal Intubation
Primary: Number of Subjects With Optimal Intubating Conditions — 61; 47 Participants — p=0.036
N/A N=117 Intraoperative Neuromuscular Blockade and Postoperative Atelectasis
Thoracic Surgery · One-lung Ventilation
Primary: Atelectasis Area on Chest CT — 1.32; 1.41 percentage of atelectasis volume
Phase 4 N=50 Postoperative Urinary Retention in Patients After Noncardiac Surgery and Reversal of Neuromuscular Block
Neuromuscular Blockade
Primary: Urine Residual in PACU — 219; 222 ml
N/A N=83 Study on the Level of Neuromuscular Blockade
Neuromuscular Blockade
Primary: Plasma Concentration of D-lactic Acid Before the Surgery — 1100.4; 1087.8 ng/ml
Phase 4 N=14 Optimizing Surgical Conditions During Gynecologic Laparoscopic Surgery With Deep Neuromuscular Blockade
Neuromuscular Blockade
Primary: Intraabdominal Distance (Centimeters) — 9.3; 9.0 centimeters — p=<0.05
Phase 4 N=102 Deep vs Moderate Neuromuscular Blockade With Rocuronium in Patients Undergoing Endolaryngeal Procedures
Laryngoscopic Surgical Procedures
Primary: Proportion of Patients Who Have a Clinically Acceptable Surgical Conditions — 0.89; 1 Proportion of patients
Phase 4 N=350 Deep Neuromuscular Block for Laparoscopic Surgery
Laparoscopy · Anesthesia Recovery Period
Primary: Percentage of Patients Recovered Cognitively at 1 Week — 91.8; 92.9 percentage of patients recovered
Phase 3 N=75 Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
Diaphragmatic Dysfunction · Muscle Weakness · Muscle Fatigue
Primary: Electric Activity of the Diaphragm (Microvolts) — 3.7; 4.5; 3.2; 2.9 microvolt
Phase 3 N=62 Comparision of Different Dose of Neostigmine at Advanced Decurarization
Anesthesia
Primary: Mesure of the Train-of-four (TOF) — 3.8; 4.5; 11.5; 19 minute
Phase 4 N=37 Optimizing Surgical Conditions During Laparoscopic Herniotomy With Deep Neuromuscular Blockade
Laparoscopic Herniotomy
Primary: Improvement of Surgical Workspace — 0; 1; 0; 0 Participants
Phase 4 N=100 Neuromuscular Blockade on Shoulder Pain of Elderly
Malignant Neoplasms of Digestive Organs · Malignant Neoplasms of Female Genital Organs · Malignant Neoplasms of Male Genital Organs
Primary: Percentage of Patients Who Reported Shoulder Pain — 12; 10 percentage of participants
N/A N=100 Effectiveness of Deep Versus Moderate Neuromuscular Blockade
Neuromuscular Blockade
Primary: Minimum Effective Analgesic Dose (MEAD) of Oxycodone at Postoperative Care Unit (PACU) — 8.0; 8.0 mg
Phase 4 N=128 The Laparotomy Study
Gastrointestinal Cancer
Primary: Surgical Rating Score — 4; 4.75 units on a scale — p=<0.05
Phase 4 N=24 Effect of Deep BLock on Intraoperative Surgical Conditions
Prostate Hypertrophy · Renal Disease
Primary: Surgical Rating Scale — 4; 4.7 units on a scale (1-5) — p=<0.001