N/A N=35 Neural Bases of Cognitive Rehabilitation for Brain Injury
Brain Injury
Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=36 Brain Function and Decision-Making
Behavior, Social · Psychology, Social · Social Interaction
Primary: Change in Prefrontal Cortex Brain Activity Assessed by fMRI — -0.002; 0.015 Percent BOLD Signal Change
N/A N=93 Neuroplasticity in TBI and Schizophrenia
Schizophrenia · Traumatic Brain Injury
Primary: Mismatch Negativity (MMN) Amplitudes in Microvolts — -0.59; -1.19; -0.41; -0.65 microvolts
Phase 4 N=61 Neurocognitive Benefits of a Weight Management Program
Overweight and Obesity
Primary: Blood Oxygen Level-dependent (BOLD) Response to High-calorie Foods Cues Minus Neutral Objects in Left Anterior Cingulate Cortex — -0.05; -0.16 percent BOLD signal change
N/A N=30 Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders
Conversion Disorder
Primary: Gray Matter Volume Biomarkers of 6 Month Prognosis as Measured by Voxel Based Morphometry - Within Group Comparison — 4.18; 3.27; 3.85; 3.76 peak voxel z-score
N/A N=76 Neural Basis of Sensory and Motor Learning: Functional Connections
Basic Science
Primary: Resting-state PMv-M1 Functional Connectivity (Fisher Z-transformed Correlation) — 0.64 unitless (Fisher z-score)
Phase 1 N=157 Teen Brain Training (TBT)
Suicide, Attempted · Suicide, Ideation · Depression
Primary: Columbia Suicide Severity Rating Scale (CSSRS) - Visit 1 — 2.08; 2.37 points
N/A N=160 Neurobehavioral Plasticity to Regular Sugar-Sweetened Beverage Intake: An fMRI Experiment
Obesity · Weight Gain
Primary: Change in Voxel-wise Blood Oxygen Level Dependent (BOLD) Including Outliers Using Functional Magnetic Resonance Imaging (fMRI) of Brain Activation Signals in Response to…
N/A N=9 Neurosciences-Intensive Care Unit Electrical Stimulation
Intensive Care (ICU) Myopathy
Primary: Duration of Intubation — 10.22 days
N/A N=20 Electrophysiologic Studies of Cognition in Epilepsy Patients
Drug-resistant Epilepsy
Primary: Heartbeat Evoked Potential (HEP) for Attention — -1.5 µV
N/A N=40 Learning in Stroke
Stroke · Sensorimotor Impairment
Primary: Learning Rate as Indexed by Change in the Precision of Visuomotor Grip Force Adjustment (i.e., Reduction of Precision Error in Force Adjustment) — -1.48; 0.303…
N/A N=92 Neuroproprioceptive "Facilitation, Inhibition" and Brain Plasticity
Multiple Sclerosis
Primary: White Matter Integrity — 0.5023; 0.5168; 0.4747 score on a scale
N/A N=8 Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity
Non-invasive Neuromodulation in Healthy Subjects
Primary: Percent Change of GABA Concentration in a Voxel Encompassing the Left Motor Cortex, Measured at 30 Min After rTMS — 8; -27 percent change
N/A N=28 Neurobehavioral Intervention as a Novel Treatment Approach for Emotion-Regulatory Deficits
Anxiety · Depression
Primary: Reaction Time to Facial Affect Identification During Emotional Conflict — 802.15; 889.14; 848.79; 937.97 milliseconds — p=0.004
Phase 2 N=40 Neuronal Correlates of Neurexan® Action in Mildly to Moderately Stressed Probands
Acute Stress Reaction
Primary: Functional Magnetic Resonance Imaging (fMRI) Task Data: BOLD Activation Changes Within Amygdala During Negative Faces in the Hariri Face Matching Task Between Placebo…
N/A N=38 The Neurobiology of Expectancy and Pain Perception
Pain
Primary: Subjective Response to Pain (0-20 Visual Analogue Scale) — 10.7; 11; 11.2; 8.1 units on a scale
N/A N=122 Exercise Effects on Brain Health and Learning From Minutes to Months
Sedentary Lifestyle
Primary: Change in Hippocampal-dependent Learning — -.00369; .00404 learning rate (proportion correct/trial) — p=<.05
N/A N=60 Neurophysiological Targets for Cognitive Training in Schizophrenia
Schizophrenia
Primary: Visual Target Detection (P300 Event-related Potential Amplitude) Change — 2.20; -0.72 microvolts (uV) — p=<0.05
N/A N=107 Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment
Mild Cognitive Impairment · Alzheimer's Disease
Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized
N/A N=40 Testing a Neurocognitive Model of Distancing Using Transcranial Magnetic Stimulation.
Emotion Regulation · Real Versus Sham Transcranial Magnetic Stimulation (TMS)
Primary: Change in Self-reported Valence (Distancing) From Baseline to 30 Minutes Post Stimulation. — .662; .668 score on a scale — p=.019
N/A N=26 Brain Stimulation and Enhancing Cognition in Older Adults
Cognitive Impairment, Mild · Depressive Symptoms · Anxiety
Primary: Cognitive and Memory Function — 56.5; 49.8 score on a scale
N/A N=21 Virtual Neuroprosthesis: Restoring a Sense of Touch to Amputees
Amputation
Primary: Artificial Hand Grasp Performance Metrics — 90.6 percentage of successful transportation
N/A N=12 Central Sodium Sensing: Implications for Blood Pressure Regulation
Salt Sensitivity of Blood Pressure
Primary: Functional Connectivity Between the Subfornical Organ and Organum Vasculosum of the Lamina Terminalis (Z-score) — 0.258490; 0.359145; 0.207372; 0.169055 z-score
N/A N=4 Feasibility - Infinitome
Alzheimer Disease
Primary: Number of Participants Who Completed Rs-fMRI — 4 Participants
N/A N=78 Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Anxiety · Depression · Personality Disorders
Primary: Time to Return to Heart Rate Baseline During the Regulation Period During Training — 1.591; 1.828; 1.505; 1.534475 log (seconds) — p=0.019
N/A N=180 The BrainHealth Project - Pilot Study
Healthy
Primary: The BrainHealth Index — 54 score on a scale — p=<0.001
N/A N=33 Neurobiological Principles Applied to the Rehabilitation of Stroke Patients
Stroke
Primary: Aim 1: Mean Parameter Estimate for Maximal Motor Evoked Potential (MEPmax) Derived From Stimulus Response Curves (SRC) — 1.01; 1.63; 1.29; .73 mV
N/A N=40 CogT BEEM Study (a tDCS Study)
Mild Cognitive Impairment · Neuropsychiatric Syndrome
Primary: Change of C3 Activation (NPS-shared Neural Circuit Measure — -0.15; 0.01 change of arbitrary unit LPG activation — p=<0.05
N/A N=58 Maximizing the Impact of Neuroplasticity Using Transcranial Electrical Stimulation Study 1
Transcranial Direct Current Stimulation · Healthy
Primary: Changes in Thalamocortical Functional Connectivity (FC) — 22.7; 20.5; 21.9 arbitrary units
N/A N=39 Beta Events and Sensory Perception
Beta Rhythm · Tactile Perception
Primary: Threshold-Level Tactile Detection Hit Rate — 0.37; 0.46; 0.47; 0.32 # hit trials/(total # hit + miss trials) — p=0.0031