N/A N=22 Nociceptive Pain Fiber Response
Painful Peripheral Diabetic Neuropathy
Primary: Changes in Small Nerve Fiber Density by Assessment of a Skin Biopsy Comparing Baseline to Day 60 — .1; .1 nerve fibers / mm squared
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=14 Release of Nociceptin From Granulocytes in Sepsis
Sepsis · Septic Shock · Sepsis Syndrome
Primary: Proportion of Responsive Biosensor Cells Responding to Granulocyte Addition in the Presence and Absence of NOP Antagonist — 34.25907426; 5.882352941; 44.17193917…
Phase 4 N=20 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold
Healthy
Primary: Hot and Cold Thermal Sensory Threshold for Pain at Baseline in Degrees Celsius. — 43.93; 43.0; 14.81; 13.33 degrees Celsius — p=.47
N/A N=156 Acute Pain Genomic Study
Osteoarthritis · Postoperative Pain
Primary: NRS-Pain With Movement on POD 2 — 2.83 units on a scale
N/A N=50 Electrical Skin Conductance Monitoring as an Assessment of Post Operative Pain Scores
Postoperative Pain
Primary: Numeric Pain Rating Scale — 2.0; 2.7; 2.9 units on a scale
N/A N=200 The Impact of SCN9A Gene Polymorphism on Individual Pain Perception in the General Population
Pain · Surgery
Primary: Opioid Consumption Dose 48h After Operation. — 37.4; 50.4 microgramme
Phase 2 N=11 The Role of N-acetyl-l-cysteine (NAC) as an Adjuvant to Opioid Treatment in Patients With Chronic Neuropathic Pain
Neuropathic Pain
Primary: Opioid Use — 101.24; 104.56 morphine equivalent dose
N/A N=38 The Neurobiology of Expectancy and Pain Perception
Pain
Primary: Subjective Response to Pain (0-20 Visual Analogue Scale) — 10.7; 11; 11.2; 8.1 units on a scale
N/A N=10 N-of-few Study of Pain Perception
Healthy
Primary: Within Participant Subjective Ratings of Acute Thermal Pain Following High Compared to Low Cues (Learned Via Symbolic Learning) — 7.32 score on a scale — p=0.043
N/A N=7 Opioid Taper Study
Chronic Pain
Primary: Pain Perception Measured Using the Cold-pressor Test (CPT) — 24.01; 42.02 seconds
Early Phase 1 N=13 Non-Opioid Pramipexole and Pain
Chronic Pain
Primary: Brief Pain Inventory Score — 8; 6.7 score on a scale
N/A N=7 Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
Postoperative Pain
Primary: Change From Baseline of Surgical Site Pain Level (NRS) at Rest [Percentage of Baseline Pain] — 64; 100; 55; 69 percentage of baseline
Early Phase 1 N=22 Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Chronic Pain · Opiate Dependence · Lower Back Pain
Primary: Change in Quantitative Pain Testing Following Active TMS Compared to Baseline — 1.4; .3 Change from Baseline (degrees C) — p=.83
Phase 3 N=645 NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain
Pain · Back Pain · Low Back Pain
Primary: Sum of Pain Intensity Difference (SPID) for Low Back Pain - Summary Statistics at 120 Hours (With Imputation) — 264.6; 264.0 Units on a scale — p=0.9703
N/A N=100 Mechanisms of Sleep Disruption Hyperalgesia
Sleep Deprivation · Pain
Primary: Spinal Sensitization as Assessed by Area of Secondary Hyperalgesia (2HA) After Two Nights of Uninterrupted Sleep and Two Nights of 8 Forced Awakenings — 1276.25…
N/A N=105 NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Musculoskeletal Pain · Pain, Chronic
Primary: Short Physical Performance Battery (SPPB) — 10.95; 10.82; 11.75 score on a scale — p=0.0561
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
N/A N=93 Observational Study With Neupro® to Evaluate the Patient´s Perception of Pain Associated With Parkinson´s Disease
Idiopathic Parkinson's Disease
Primary: Change From Baseline to Visit 2 in the Sum Score Calculated From the 4 Items of the Affective Dimension of the Pain Description List (Schmerzbeschreibungsliste SBL…
Phase 1 N=104 Neuropathic Pain Syndrome Patient Study (MK-0000-072)
Neuralgia, Postherpetic · Diabetic Neuropathy · Painful Small-Fiber Neuropathy
Primary: Daily Evening Patient Reported Pain Intensity Scores — 0.14; 1.57 Units on a Scale — p=0.003
N/A N=8 Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Central Post Stroke Pain
Primary: Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block. — 6.5; 0.0 units on a scale
Phase 3 N=805 Nonivamide/Nicoboxil Ointment in Acute Low Back Pain
Acute Low Back Pain
Primary: Pain Intensity Difference (PID) Between Pre-dose Baseline and 8hours After First Application — -1.049; -1.428; -2.252; -2.410 units on a scale — p=<0.0001
N/A N=65 Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Pilot Study
Rotator Cuff Repair · Anterior Cruciate Ligament Reconstruction · Ankle Arthrodesis or Arthroplasty
Primary: Opioid Consumption During First Postoperative Week — 5.0; 47.5 mg
N/A N=134 Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
Infant, Newborn · Infant, Premature · Pain Perception
Primary: Change in Nociception-specific Brain Activity — 17.9; 9.9; 11.5; 10.2 microvolts*milliseconds — p=<0.001
Phase 3 N=140 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast Cancer Patient
Primary: Change in Neuropathic Pain Score at 2 Months (Numeric Rating Scale 0-10) — 4.1; 4.6 units on a scale
N/A N=75 Nociceptors, Neurotrophic Factors and Cytokine Expression in Gastroesophageal Reflux Disease
Gastro-esophageal Reflux Disease
Primary: TRPV1, GDNF, and NGF mRNA Expression of Esophageal Mucosa — 1.14; 3.25; 2.33; 1.39 Fold change
N/A N=50 Osteoarthritis Structural Changes Assessed by Magnetic Resonance Imaging and Neuropathic Pain in Knee Osteoarthritis
Neuropathic Pain · Knee Osteoarthritis
Primary: Osteoarthritis Structural Changes Assessed by Quantitative Magnetic Resonance Imaging With and Without Neuropathic Pain — 14; 7; 5; 1 participants
N/A N=7,103 Non-pharmacological Pain Management After Surgery
Surgical Procedure, Unspecified
Primary: PROMIS-CAT Pain — 59.32; 59.96; 56.94; 56.06 score on a scale
N/A N=29 Low Intensity Focused Ultrasound Pulses (LIFUP) to Modulate Pain
Healthy Adults
Primary: Quantitative Sensory Threshold Temperature Levels (Degrees Celsius) — .51; 1.08 Degrees Celsius
Phase 1 N=19 Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers
Healthy
Primary: Average Pain (0-120 Seconds): Cold Pain Test Visual Analog Scale (VAS) — 45.2; 45.5; 45.0; 44.9 mm
Phase 2 N=39 Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment
Chronic Pain
Primary: Post-operative Morphine Consumption — 54.6; 44.8 mg — p=0.5