Phase 3 N=602 Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis
Adult Periodontitis
Primary: Change in Pocket Depth. — -1.4; -1.6; -1.4 mm
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=38 Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy
Periodontitis
Primary: Change in Pocket Probing Depth (PPD) — 3.932; 4.082; 3.253; 3.294 mm
N/A N=40 Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease
Periodontal Diseases
Primary: Change in Number of Bleeding Sites (Bleeding On Probing) — -1.60; -1.40 bleeding sites
N/A N=132 Effects of Different Irrigation Activation Techniques on the Healing of Large Periapical Lesions
Periapical Periodontitis · Irrigation Activation · Lasers
Primary: Post-operative Diameter of the Periapical Lesion — 2.07; 0.98; 1.12; 0.78 Post-operative lesion diameter- mm2
Phase 4 N=51 Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Periodontitis
Primary: Periodontal Probing Depth — 2.5; 3.2; 3.4 millimeter
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
N/A N=30 Implant Surface Decontamination in Peri-implantitis Treatment
Peri-implantitis · Periodontal Disease
Primary: Change in Total Bacterial Load on the Exposed Implant Surface — 2.77; 4.21 log (colony forming units/ml)
Phase 4 N=56 Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation
DENT IMPLANTS · LASER
Primary: Mean Probing Pocket Depth — 4.62; 4.45 millimeters
Phase 4 N=32 Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Periodontitis
Primary: Periodontal Pocket Depth-PPD — 3.735; 3.696 mm — p=0.429
N/A N=45 Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections
Periapical Periodontitis · Bacterial Infections
Primary: Metabolic Activity of Persistent Bacteria — 4.748; 2.57; 2.614; 4.0008 RNA/DNA ratio
N/A N=24 Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis
Peri-Implantitis
Primary: Change in Periodontal Probing Depths (PD) — 1.85; 2.65 millimeters
Phase 4 N=39 Alternative Antibiotic Regime in the Treatment of GAgP
Generalized Aggressive Periodontitis · Aggressive Periodontitis
Primary: The Primary Outcome Variable Was Probing Depth. — 4.57; 4.18; 3.12; 2.91 mm — p=<0.01
N/A N=40 Clarithromycin as Adjuvant to Periodontal Debridement
Aggressive Periodontitis
Primary: Clinical Attachment Level — 2.71; 3.03 milimeter
Phase 3 N=42 Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes
Periodontitis · Periodontal Pocket · Diabetes Mellitus
Primary: Probing Depth — 0.44; 0.50 mm — p=<0.05
N/A N=70 Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions
Effect of Irrigation Activation on Periapical Healing
Primary: Percentage Change in Lesion Volume at 12-months Follow-up — 80.429; 85.429; 86.929; 74.571 percent change — p=<0.05
Phase 3 N=46 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
Aggressive Periodontitis
Primary: Change in Clinical Attachment Level (CAL) — 3.69; 3.62; 2.4; 3 mm
Phase 4 N=70 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis
Chronic Periodontitis
Primary: Pocket Depth — 4.34; 4.81; 4.5 mm
N/A N=31 Peri-implantitis Treatment: Clinical Results of Conventional Treatment vs. the Addition of Biolase
Peri-Implantitis
Primary: Change in Probing Depth (PD) — -0.73; -1.36 mm
N/A N=5,117 Periodontal Disease Prevention Study
Periodontitis
Primary: Percentage of Participants With Tooth Loss Over 16 Year Period — 16.4; 13.8; 22.1; 16.9 percentage of participants
N/A N=51 Kidney and Periodontal Disease Study
Chronic Kidney Disease · Periodontal Disease
Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants
Phase 1 N=84 Effect of Triple Antibiotic Paste as an Intracanal Medication With an Anti-Inflammatory Drug on Post-operative Pain.
Asymptomatic Necrotic Teeth
Primary: Post Operative Pain — 3.18; 2.27; 2.20; 1.39 score on a scale — p=0.083
Phase 3 N=39 Collection of Gingival Crevicular Fluid From Periodontitis Patients
Gingival Diseases
Primary: Metabolite Associated With Inflammation (Cadaverine) — 1.119186; 0.92077 ion count — p=<0.05
N/A N=44 Lactobacillus Reuteri in the Supportive Therapy of Periodontitis
Periodontal Diseases
Primary: Change in PD (Periodontal Depth) — 5.63; 5.45; 4.01; 4.03 millimeter
N/A N=59 Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodontitis
Chronic Periodontitis
Primary: Gain in Clinical Attachment Level of Periodontal Tissues — 1.361; 2.387; 1.180; 2.329 mm
N/A N=34 Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Chronic Peridontitis Patients · Chronic Gingivitis · Healthy
Primary: Pocket Depth — 1.60; 2.50; 6.75 millimetres
Phase 3 N=102 Periodontal Infection and Endothelial Dysfunction
Periodontitis
Primary: Brachial Artery Flow-mediated Dilation — 10.2; 10.3; 13.1; 8.1 Percentage of dilatation of brachial art — p=0.98
N/A N=32 Effects of Photobiomodulation on Postoperative Pain After Primary Endodontic Therapy in Molars With Symptomatic Apical Periodontitis
Postoperative Pain
Primary: Pain as Assessed by the Visual Analog Scale — 0; .33 score on a scale
Phase 4 N=42 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients
Aggressive Periodontitis
Primary: Probing Depth — 4.55; 4.80; 4.90; 2.71 mm — p=<0.01
N/A N=4 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material
Dental Pulp Diseases · Dental Pulp Necrosis · Nerve Root Pain Nec
Primary: Percent Reduction in Apical Radio-lucency — 17.4; 27.1 % Change in Diameter (mm)
N/A N=41 Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans
Periodontitis
Primary: Change in Clinical Attachment Level (CAL) — 1.21; 1.03 mm