N/A N=17 Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
Physiological Changes in Deliberate Apnea
Primary: Cardiac Function: Duration of Apnea — 483 sec
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=22 Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Sensitivity
Primary: Sensory Function — 46.7; 46.4; 46.1; 45.9 Degrees celsius — p=0.592
N/A N=50 The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients
Hypoxia
Primary: PaO2(Partial Pressure of Oxygen in Arterial Blood) — 178.71; 198.04; 185.25; 202.54 mmHg
N/A N=20 The Psychophysiological Effect of Simulated and Terrestrial Altitude
Hypoxia · Altitude Hypoxia · Altitude Sickness
Primary: Oxygenation of the Brain — 54.6; 54.3; 59.4; 55.4 percentage of oxygen saturation
N/A N=25 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia
Brain Hypoxia
Primary: Change in Glutamate Concentration During a Visual Stimulus Measured by fMRS at Normoxia — 4 percentage of concentration (micromol/g)
N/A N=29 Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
Amyotrophic Lateral Sclerosis (ALS) · Neuromuscular Diseases
Primary: Percent Change in Maximal Inspiratory Pressure (MIP) — 0.3; -3.1; -4.8; -5.0 percentage change in MIP from baseline
Early Phase 1 N=63 Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
Sleep Apnea Syndromes
Primary: Ventilation (Aim 1) — 1.19; 1.14; 1.35; 1.16 fraction of baseline — p=0.001
N/A N=50 EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation
Obesity, Morbid
Primary: Non Hypoxic Apnea Time — 216.7; 258.2 seconds — p=0.005
N/A N=17 Slow Yogic-Derived Breathing and Respiration and Cardiovascular Variability in Spinal Cord Injury Patients
Spinal Cord Injuries · Slow Breathing
Primary: HRV — 1421; 813; 3173; 2819 ms^2
N/A N=92 Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep
Sleep Apnea · Age
Primary: Apneic Threshold (AT) and Carbon-dioxide (CO2) Reserve — 39.8; 36.7; -4.1; -2.6 mm Hg — p=<0.05
N/A N=80 Physiological Changes With High-Flow Nasal Cannula
Respiratory Distress Syndrome in Premature Infant
Primary: Percent of Unventilated Lung as Assessed by Electrical Impedance Tomography — 2.18; 2.32; 1.72; 2.17 Percent of unventilated lung regions
N/A N=47 Estimating Apnea Phenotypes From Polysomnography: Oxygen
Sleep Apnea
Primary: Apnea-hypopnea Index — 40.5; 57.9; 48.5; 74.3 events/hour — p=0.4
Phase 4 N=33 Neuroimaging During Pure Oxygen Breathing
Hyperoxia · Hypoxia, Brain · Neurobehavioral Manifestations
Primary: Cerebral Blood Flow — 48.54; 36.17 ml/min/100g tissue — p=<0.05
Phase 4 N=44 The Impact of Arousal Threshold in Obstructive Sleep Apnea
Obstructive Sleep Apnea
Primary: Apnea Hypopnea Index (AHI) — 50.0; 51.8 events/hour — p=0.576
N/A N=20 EPO2-PV: Evaluation of Pre-Oxygenation Conditions in Morbidly Obese Volunteer: Effect of Position and Ventilation Mode
Morbid Obesity · Bariatric Surgery Candidate
Primary: Functional Residual Capacity — 2573; 2145; 2456; 2219 ml
N/A N=20 Comparing Nose & Mouth Breathing During Exercise
Healthy
Primary: Blood Pressure During Exercise Between Study Arms — 142; 146 mmHg
Phase 4 N=14 Sleep and Breathing in the General Population - Chemical Stimuli
Sleep-disordered Breathing
Primary: The Central Apnea-hypopnea Index — 14.1; 29.9 events per hour
N/A N=62 Impact of the Inspiratory Cortical Control on the Outcome of the Ventilatory Weaning Test in Patients Intubated in Resuscitation
Respiration Disorder · Respiratory Failure · Weaning Failure
Primary: Magnitude of Inspiratory Premotor Potentials — 1.2; 2.1 µV
N/A N=15 Upper Airway Physical Therapy for the Treatment of Obstructive Sleep Apnea
Obstructive Sleep Apnea Syndrome
Primary: Delta of Apnea Hypopnea Index (AHI) as Measured by Polysomnography (PSG) — 4.27 events per hour
N/A N=86 Pulmonary Function After Hyperbaric Oxygen Therapy
Oxygen Toxicity
Primary: Change in Percentage Predicted Forced Expiratory Volume in One Second (FEV1%) — 88.0; 85.9; 87.4; 84.6 Percentage of FEV1
N/A N=7 Assessing Variability of the Ventilatory Response to Duffin's Rebreathing Procedure
Ventilation · Reproducibility · Physiology
Primary: Baseline Minute Ventilation — 11.6; 12.0 L/min
N/A N=70 Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
Obstructive Sleep Apnea · Hypoxemia
Primary: ODI — 24.71; .97 events/hour
N/A N=26 Four Methods of Pre-oxygenation
Respiratory Failure
Primary: Exhaled Oxygen Concentration — 72; 86; 54; 77 % FeO2
Phase 4 N=18 The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
Airway Complication of Anaesthesia · Healthy
Primary: Upper Airway Closing Pressure — -9.83; -10.77 cm H20
N/A N=31 Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome
Sleep-disordered Breathing · Snoring
Primary: Pleural Pressure (Pes) — 9.3; 4.4 mmHg
N/A N=72 Positive Pressure at Induction of Anesthesia in Children
Continuous Positive Airway Pressure · Hypoxia · General Anesthesia
Primary: Time Between Onset of Apnea and the Drop in 95% Oxyhemoglobin Saturation Levels — 227.65; 133.68 seconds — p=<0.0001
N/A N=44 Breathe: Slow Paced Breathing to Lower Blood Pressure
High Blood Pressure
Primary: Breathing Rate — 9.4; 13.7 Breaths/minute
N/A N=8 Apnea Hypopnea Index Severity Versus Head Position During Sleep
Sleep Disordered Breathing · Sleep Hypopnea · Sleep Apnea
Primary: Number of Participants With Apnea Hypopnea Index (AHI) Severity Improvement — 8 Participants — p=<.05
N/A N=150 Preoxygenation With Positive Inspiratory Pressure During Induction of Anesthesia
Anesthesia
Primary: Time for Preoxygenationfrom Face Mask Positioning to FEO2=90% — 190; 153; 140 seconds
N/A N=360 Apneic Oxygenation During Airway Management in Pediatric Patients
Hypoxia
Primary: Time to First Event: Pulse Oximetry at 95%, or Successful Intubation — 106; 169 seconds