N/A N=62 Air Pollution Study: The Effect of Ozone on the Lung
Air Pollution
Primary: Concentrations of M1 and M2 Macrophages in the Sputum 24 Hours After Exposure. — 6.823; 1.367 ratio of M2 to M1 macrophages
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=2,123 Effect of Air Pollution on the Cognitive Function of Adolescents
Attention Impaired · Risk-Taking · Risk Behavior
Primary: Response Speed Consistency Throughout the Attention Network Task-Flanker Task (Post ANT) — 161.3; 160.2 ms — p=0.52
N/A N=60 Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
Asthma
Primary: Spirometry, Percentage Change in FEV1 From Baseline — -1.0; -4.8; -2.2; -7.4 percentage change in FEV1 from baseline — p=<0.05
N/A N=33 Reducing Particulate Matter-associated Cardiovascular Health Effects for Seniors
Cardiometabolic Health
Primary: Systolic Blood Pressure — 127.0; 126.5 mm Hg — p=0.588
N/A N=77 Reducing Traffic Pollution Exposure Improves Blood Pressure
Air Pollution
Primary: Systolic Blood Pressure (SBP) — 122.3; 120.83; 119.9 mmHg
N/A N=70 Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution
Oxidative Stress · Inflammation · Blood Pressure
Primary: Biomarkers of Antioxidant Activity-Total Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD) — 6.09; 5.80; 364.34; 356.59 U/ml
Phase 2 N=170 Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants
Environmental Carcinogenesis
Primary: Sulforaphane Bioavailability Measured in Sequential 12-Hour Urine Samples — 24.8; 11.0; 4.3 micromoles/24 hours — p=<0.001
N/A N=23 Effects of Reducing Indoor Air Pollution on the Adult Asthmatic Response
Asthma
Primary: PM2.5 Concentration (ug/m^3) — 18.95; 32.73 ug/m^3
N/A N=50 Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Abnormality, Respiratory System · Autonomic Nervous System
Primary: FEV1 — 0.94; 1.08; 0.95; 1.09 percentage of predicted normal values
N/A N=225 Improving the Behavioural Impact of Air Quality Alerts
Pollution; Exposure · Health Behavior
Primary: Adoption of Protective Behaviour at 4 Weeks — 3.67; 4.25; 4.29; 3.65 units on a scale 1-9 — p=.964
N/A N=9 Residential Cleaning of Indoor Air to Protect COPD Patients
Chronic Obstructive Pulmonary Disease
Primary: Mean Change in St. George Respiratory Questionnaire — -12.5; -0.45 score on a scale
N/A N=434 Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals in Adults of Child-Bearing Age
Endocrine Disrupting Chemicals · Environmental Exposure · Health Literacy
Primary: Changes in Endocrine Disrupting Chemical (EDC) Levels as Measured by the Post-intervention Value Minus the Baseline Value. — 5.83; 18.43; 56.94; 75.30 ng/ml — p=<0.05
N/A N=330 PRIDE: Preventing Respiratory Illnesses During Childhood Study
Tobacco Smoke Pollution
Primary: Air Nicotine Levels — 1.17; 0.58; 0.71; 0.51 mg/m^3
N/A N=28 Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators
Autonomic Nervous System Imbalance · Blood Pressure · Inflammation
Primary: Heart Rate Variability-LF Power,HF Power,VLF Power — 899.4; 838.5; 519.7; 416.6 ms^2 — p=<0.05
N/A N=299 Nucleophilic Defense Against PM Toxicity (NEAT Trial)
Air Pollution Toxicity
Primary: Endothelial Progenitor Cells — 0.0025; 0.0027 # cells per CD41 minus cells
N/A N=401 Real-Life Passive Exposure Assessment of IQOS
Environmental Exposure
Primary: NEQ: (Non-Exposure Event) — 0.03845; 4.159; 5.695; 0.06876 mg/g
N/A N=20 Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise
Ozone Exposure During Rest and Exercise
Primary: Time-to-exhaustion on Maximal Cycling Bout — 209; 235 seconds — p=0.092
N/A N=39 DRIIVE (Data and Research on Interventions to Improve the Vehicular Environment)
Vehicular Environment
Primary: Collect Preliminary Data on In-vehicle Excess Particulate Matter (PM) Exposure
N/A N=60 Health Effects of Indoor Air Filtration in Healthy Chinese Adults
Blood Pressure
Primary: Changes of Serum Cortisol Levels — 0.012835; 0.016206 relative intensity — p=<0.05
N/A N=38 Broccoli Sprout Extract Effects on Allergic Inflammation in the Nose
Allergic Airway Disease
Primary: Total Nasal Cell Count in Response to DEP Challenge at 0, 6 and 24 hr With or Without BSE Intervention — 4.44; 4.50; 4.73; 4.70 log cells/mL — p=<0.001
N/A N=10 Circadian Rhythm Disruption Effects on Smoke Inhalation
Inflammation · Sleep Deprivation · Circadian Rhythm Sleep Disorder, Shift Work Type
Primary: Blood Inflammation — 0.69; 0.79; 2.33; 1.63 pg/mL — p=<0.05
N/A N=40 Acute Effects of Cigarette Packaging and Charcoal Filtration on Perceptions, Use Behaviors, and Harm Exposure
Smoking Behaviors
Primary: Number of Puffs Taken (Video-scored Smoking Behavior Outcome 1) — 15.8; 16.7; 19.1; 19.6 puffs
N/A N=163 Impacts of Clinician-Mediated Report-Back
Health Knowledge, Attitudes, Practice
Primary: Knowledge Before and After Report-back Intervention. — 0.06; 0.02 Scores on a scale
N/A N=24 Evaluation of Post-Exposure Sauna Treatment of Firefighters - A Pilot Study
Post-fire Rehabilitation of Firefighters in Sauna
Primary: Urinary Excretion of Hydroxylated PAHs (PAH-OHs) — 10364.2; 40012.1; 6964.1; 22604.3 ng/L — p=0.0000009
N/A N=987 Reducing Pesticide Exposures in Child Care Centers
Children, Only · Risk Reduction · Environmental Exposure
Primary: Decrease in Child Care Center Pesticides — 1.95; 1.87; 0.59; 0.53 log10(ng/g) — p=<0.05
Early Phase 1 N=8 Benzo[a]Pyrene Ultralow Dose-Response Study
Environmental Exposure
Primary: Peak Plasma Concentration Cmax — 2.51; 5.68; 13.8; 8.99 fg [14C]-BaP/mL plasma
Early Phase 1 N=28 Intervention to Reduce Body Burdens of PCBs in Residents of Anniston, Alabama
Toxic Effect of Other Corrosive Organic Compounds
Primary: Percent Change From Baseline for Total PCB Levels — 92; 96 % of baseline total PCBs
N/A N=9 Woodsmoke Particulate + Hypertonic Saline
Airway Inflammation
Primary: Change From Baseline to 4 Hours in Sputum Percent Neutrophils — -0.04; -0.5 percent neutrophils — p=> 0.99
Early Phase 1 N=8 Ultralow Dose PAH Binary Mixture Study
Environmental Exposure
Primary: Peak Plasma Concentration of 14C-BaP Cmax — 7.07; 1.60 fg [14C]-BaP/mL plasma
Phase 2 N=12 Woodsmoke Particulate + Prednisone
Airway Inflammation
Primary: Change From Baseline to 4 Hours in Sputum Percent Neutrophils — -2.62; 5.45 percent neutrophils — p=0.24