N/A N=293 Mu-Opioid Receptor Genetic Polymorphism and Intrathecal Analgesia
Labor Pain · Post-cesarean Delivery
Primary: Duration of Intrathecal Fentanyl Analgesia — 70; 63 Minutes — p=0.54
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=78 CYP2B6 Polymorphisms in Methadone Disposition
Healthy Volunteers
Primary: Methadone Metabolism — 0.082; 0.073; 0.054 ratio — p=<0.05
N/A N=165 Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy
Congenital Heart Disease
Primary: To Evaluate the Incidence of the Pre-proendothelin SNP at Nucleotide 5665 — 10 participants
N/A N=88 GLP1R Polymorphisms and Response to GLP1
Diabetes
Primary: Insulin Secretion at 150-180 Minutes. — 104; 94; 81; 92 10^-9 min^-1 — p=0.11
N/A N=106 Variability in Adrenergic Response
Vascular Reaction to Medications
Primary: ED50 After Phenylephrine — 172; 310 ng/min
N/A N=92 Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events
Systemic Arterial Hypertension · Hypertension Resistant to Conventional Therapy · Myocardial Infarction
Primary: Strokes, Either Fatal or Nonfatal — 24; 7 participants — p=0.19
Phase 4 N=23 Genetic Basis for Variation in the Renal Elimination of Metformin
Other Conditions That May Be A Focus of Clinical Attention
Primary: Renal Clearance of Metformin — 614; 441 mL/min
N/A N=289 CYP2D6 Polymorphism in Patients of General Practice in Austria
Disorder Due Cytochrome P450 CYP2D6 Variant
Primary: Frequency of Metabolizer Status (PM, IM, NM, UM) in Patients — 233; 22; 21; 11 Participants
N/A N=88 Pharmacogenetics of b2-Agonists in Asthma.
Asthma
Primary: Log10 PC20 to Methacholine After Visit 2 — 0.54; 0.48; 0.16; 0.53 log10 mg/mL — p=0.27
N/A N=170 Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste
Dysgeusia
Primary: Association Between Gustin Gene Polymorphism and PROP Sensitivity — 85.19; 50.99; 25.00; 14.81 percentage of participants — p=<0.01
N/A N=1,223 DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients.
Death, Sudden, Cardiac · Ventricular Fibrillation · Tachycardia
Primary: Number of Patients With Ventricular Arrhythmia <400 Msec. by GNAS c.393C>T Genotype — 63; 136; 98 participants with VT < 400 msec
Phase 4 N=105 Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar Surgery
Pain · Other Surgical Procedures · Impacted Third Molar Tooth
Primary: Score of Pain Measured by Visual Analogue Scale — 25 score on a scale (mm)
N/A N=117 Genetic Variation in Platelet Aggregation
Myocardial Infarction
Primary: LogEC50 Platelet Aggregation — 2.65; 2.62 nM
Phase 4 N=31 Genetics and HIV-1 Protease Inhibitors
HIV
Primary: Day 7 Atazanavir Oral Clearance — .25; .18 L/h/kg
Phase 2 N=97 A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans
Opioid Sensitivity · Individual Difference · Abuse Opioids
Primary: Self-report Visual Analog Ratings of HIGH — 7.2; 6.6; 4.5; 5.6 score on a scale — p=0.567
N/A N=30 CYP2B6 Polymorphisms in Ketamine
Healthy Volunteers
Primary: The Effects of CYP2B6 Genetic Variants on Ketamine Metabolism and Clearance by CYP2B6*6 Hetero or Homozygote Genotype. — 29; 21; 26; 19 ng/ml*hr — p=<0.05
N/A N=26 Pharmacogenetics of Metformin Action in PCOS
Polycystic Ovary Syndrome
Primary: Number of Responders/Non-responders for Each STK11 rs8111699 Genotype (C/G, C/C, G/G) — 6; 7; 5; 3 participants
Phase 4 N=199 The Clinical Response of Choline Acetyltransferase and Apolipoprotein Epsilon Gene Polymorphisms to Donepezil in Alzheimer's Disease
Alzheimer's Disease
Primary: CERAD-K (the Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease) — 8.28; 7.31; 17.86; 10.62 Units on Scale
N/A N=176 Impact of CYP3A4*1G Polymorphism on Metabolism of Fentanyl in Chinese Patients Undergoing Lower Abdominal Surgery
Pain · Surgery
Primary: CYP3A4*1G Polymorphism — 103; 66; 7 participants
Phase 4 N=19 Pharmacogenomics of Antiplatelet Response - I
Platelet Aggregation · Platelet Transcriptome · Coronary Artery Disease
Primary: Difference in ADP-induced Platelet Aggregation — -5.2 Difference in ohms (Post-Pre)
N/A N=200 The Impact of SCN9A Gene Polymorphism on Individual Pain Perception in the General Population
Pain · Surgery
Primary: Opioid Consumption Dose 48h After Operation. — 37.4; 50.4 microgramme