N/A N=406 National Cardiogenic Shock Initiative
Cardiogenic Shock · Acute Myocardial Infarction · STEMI - ST Elevation Myocardial Infarction
Primary: Number of Participants Who Survived at Discharge — 287 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=20 Cardiogenic Shock Intravascular Cooling Trial
Cardiogenic Shock
Primary: Number of Participants With Episodes of Arrhythmia — 0; 1 Participants — p=1
N/A N=141 Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Cardiac Arrest
Primary: Survival Rate - Number of Participants Alive — 55; 20; 32; 34 Participants — p=<0.001
N/A N=47 Synchronized Cardiac Assist for Cardiogenic Shock
Shock, Cardiogenic · High Risk Percutaneous Coronary Interventions
Primary: Number of Participants With Device and Procedure Related Serious Adverse Events — 11; 5 Participants
N/A N=677 Unexpected Cardiac Arrest in Intensive Care Unit
Heart Arrest
Primary: Number of Patients With Unexpected Cardiac Arrest — 677; 30,722 Participants
Phase 2 N=50 Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest
Cardiac Arrest
Primary: Time to Shock Reversal — 55; 49 hours
Phase 4 N=129 Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema
Acute Cardiogenic Pulmonary Edema
Primary: Number of Patients Who Were Intubated — 5; 4; 10 participants
N/A N=142 Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery
Shock · Cardiovascular Diseases · Critical Illness
Primary: Perfused Vessel Denisty (PVD) — 22.8; 23.8; 20.2; 22.5 mm/mm^2
Phase 2 N=101 AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
Traumatic Shock
Primary: Number of Blood Products Transfused — 1.7; 3.0 Litre
N/A N=51 NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock
SIRS · Sepsis · Shock
Primary: Pattern of NT-proBNP, Biomarkers and Surface Markers on Leukocytes — 902; 4,429 pg/ml
Phase 1 N=20 Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
Septic Shock
Primary: Standing Dose of Norepinephrine Which is Required to Maintain a Mean Arterial Pressure (MAP) of 65 mmHg - Hour 1 — 7.4; 27.6 mcg/min
Phase 2 N=7 Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia
Septic Shock
Primary: Organ-failure-free Days — 26 units on a scale
N/A N=44 Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.
Circulatory Shock · Cardiovascular Shock
Primary: Perfused Vessel Density (PVD) — 24.81; 20.44; 26.41; 21.88 mm/mm^2
Phase 3 N=295 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial
Cardiac Arrest
Primary: Survival With Good Neurobehavioral Outcome — 27; 15; 111; 107 Participants — p=0.14
N/A N=48 Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest
Cardiac Arrest · Sudden Cardiac Death
Primary: Mean Systolic and Diastolic Blood Pressures — 80.38; 121.21; 61.37; 15.52 mmHg
N/A N=329 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial
Cardiac Arrest
Primary: Survival With Good Neurobehavioral Outcome — 48; 48; 85; 76 Participants — p=0.63
N/A N=4,132 Medtronic Shock-Less Study on Physician Utilization of Shock Reduction Programming
Cardiovascular Disease
Primary: Change in Shock Reduction Programming Adoption — 13.6; 6.8; 9.0; 3.5 percentage of participants — p=<0.0001
Phase 2 N=100 Physiologic Effects of Steroids in Cardiac Arrest
Inhospital Cardiac Arrest
Primary: Early Postresuscitation Arterial Blood Pressure (mmHg) Measured Through Institution of Invasive Intra-arterial Pressure Monitoring (as Feasible). — 78.4; 75.1 mmHg…
Phase 2 N=74 Intensive Glycemic Control for Congestive Heart Failure Exacerbation
Congestive Heart Failure · Diabetes Mellitus
Primary: Hospital Length of Stay — 7; 8 days
N/A N=3,889 Improve Sudden Cardiac Arrest Study
Sudden Cardiac Arrest · Ventricular Arrythmia
Primary: Time to the First Occurrence of a Ventricular Arrhythmia — 32.5; 18.3 Estimated 24-Month VT-VF Pct of Patients
Phase 2 N=2 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest
Cardiac Arrest
Primary: Intervention Compliance — 1 participants
N/A N=15 ECPR for Refractory Out-Of-Hospital Cardiac Arrest
Cardiac Arrest · Heart Arrest · Sudden Cardiac Arrest
Primary: Emergency Department Arrivals Under 30 Minutes — 5 Participants
Phase 3 N=188 Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)
Heart Failure
Primary: Change in Serum Creatinine — -0.04; 0.23 mg/dL
N/A N=114 Non-invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema
Cardiogenic Pulmonary Oedema
Primary: Need for an Endotracheal Intubation Within Seven Days After Onset of Cardiopulmonary Edema at the Intensive Care Unit — 5; 5 Participants — p=1.000
N/A N=22 Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
Cardiac Arrest
Primary: Microvascular Flow Index (MFI) — 1.7; 1.1 units on a scale
Phase 1 N=24 Phase 1 Study to Evaluate Safety, Tolerability and Pharmacokinetics/-Dynamics of AK1967 (Procizumab)
Safety and Tolerability · Healthy Volunteers
Primary: Safety and Tolerability — 7; 8; 12; 3 AEs
N/A N=17 Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
Physiological Changes in Deliberate Apnea
Primary: Cardiac Function: Duration of Apnea — 483 sec
Phase 4 N=314 Effects of Microplegia on Transfusion Rates After Cardiac Surgery
Aortic Valve Disease · Mitral Valve Disease
Primary: Intraoperative and Postoperative Transfusions — 2.43; 2.97; 4.42; 3.50 units of blood per participant — p=0.354
N/A N=15 Clinical Hemodynamic Study of Balloon Counterpulsation in Advanced Heart Failure
Heart Failure
Primary: Impact of Intra-aortic Balloon Pump Activation on Left Ventricular Stroke Work. — 939; 5628; 667; NA mmHg-mL
Phase 4 N=28 Renin and Renal Biomarker Response to Angiotensin II
Septic Shock · Acute Kidney Injury
Primary: Change in Plasma Renin Levels — -15; 69; -6; 26 pg/mL