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Home › Conditions › Gonorrhea

Gonorrhea

Part of Neisseriaceae Infections

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Gonorrhea

14 trials tracked for Gonorrhea: 5 in phase 3 or 4 and 5 with published results. The most-cited published study has 447 citations.

14Trials tracked
5Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 1 Phase 3 4 Phase 2 1 Other / NA 8
  1. Phase 4 Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men Completed · 447 cited
  2. Phase 3 A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea Completed · 69 cited
  3. Phase 3 Zoliflodacin in Uncomplicated Gonorrhoea Completed · 32 cited
  4. Phase 3 Aztreonam for Pharyngeal Gonorrhea Completed · 10 cited
  5. Phase 3 Evaluation of EVO100 for Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection Completed · 2 cited
  6. Phase 2 A Dose-Ranging Study Evaluating the Efficacy, Safety, and Tolerability of GSK2140944 in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria Gonorrhoeae Completed
Show 8 more trials
  1. N/A Pay-it-forward Gonorrhea and Chlamydia Testing Among Men in China Completed
  2. N/A Keep It Up! 2.0: A Comparison of Two Online HIV Intervention Programs for Young Men Who Have Sex With Men Completed
  3. N/A Adolescent Sexually Transmitted Infection Screening in the Emergency Department Completed
  4. N/A Computer-Assisted Self-Interviews and Health Screening in the Pediatric Emergency Department Completed
  5. N/A Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington Completed
  6. N/A Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening Completed
  7. N/A Antenatal Chlamydia Trachomatis and Neisseria Gonorrhoeae Testing to Prevent Adverse Neonatal Consequences Completed
  8. N/A A Study to Learn About How Trumenba Vaccine Shots Work Against Gonorrhea Infection in Teenagers and Young Adults in the United States. Completed

Showing the 14 most-cited and recently-updated of 14 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Gonorrhea: what the trials found

Established pharmacological interventions for gonorrhea include Doxycycline Hyclate Delayed-Release 2, Gepotidacin 3, zoliflodacin 4, Aztreonam 5, and EVO100 6. Zoliflodacin demonstrated higher rates of eradication for urogenital, pharyngeal, and rectal infections compared to a combination of Ceftriaxone and Azithromycin 4. Gepotidacin showed statistically non-significant results (p=0.5072) for urogenital site eradication when compared to other study arms 3.

Recent results — preliminary, needs further review

  • • Mobile Van Clinic delivery models 1 • Targeted STI Screening programs 8 • Motivational interviewing and specimen self-collection methods 9

For the clinician treating this condition

  • Multiple pharmacological agents, including zoliflodacin and Doxycycline, are established for the treatment of gonorrhea.
  • Zoliflodacin showed superior eradication rates across multiple sites compared to Ceftriaxone/Azithromycin combination therapy.

AI synthesis of 8 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
4CMenB vaccine did not reduce infection rates compared to placebo in MSM population
Infectious Disease RCT
4CMenB vaccine did not reduce infection rates compared to placebo in MSM population Trial shows 4CMenB vaccine does not prevent gonorrhea or syphilis
This randomized controlled trial evaluated 4CMenB in 587 men who have sex with men (MSM) recently diagnosed with gonorrhea or infectious syp…
A large trial found that a new vaccine did not reduce the rates of gonorrhea or syphilis infections in men at high risk for these conditions…
Jul 23, 2026
Syphilis prevalence is 5.20-fold higher in low-income countries among forcibly displaced populations
Infectious Disease Meta-analysis
Syphilis prevalence is 5.20-fold higher in low-income countries among forcibly displaced populations High Rates of Syphilis Found Among Displaced Populations
This meta-analysis of 1.1 million test results across 82 reports evaluates the prevalence of syphilis, gonorrhea, chlamydia, and trichomonia…
A large-scale review reveals high rates of syphilis and other infections among refugees, highlighting the need for better screening in these…
Jul 17, 2026
Meta-analysis finds 22.5% prevalence of Neisseria gonorrhoeae and high resistance to tetracycline, ciprofloxacin, and penicillin in Kenya
Infectious Disease Meta-analysis
Meta-analysis finds 22.5% prevalence of Neisseria gonorrhoeae and high resistance to tetracycline, ciprofloxacin, and penicillin in Kenya Kenya's Silent Gonorrhea Crisis Demands New Solutions Now
This systematic review and meta-analysis of 5,170 participants in Kenya found a pooled prevalence of Neisseria gonorrhoeae of 22.5%. Resista…
• Gonorrhea affects one in four high-risk Kenyans tested • Sex workers and low-education groups face highest danger • New treatments like ph…
May 5, 2026
Antibiotic-resistant Neisseria gonorrhoeae strains show increasing prevalence in China
Infectious Disease
Antibiotic-resistant Neisseria gonorrhoeae strains show increasing prevalence in China Are gonorrhea treatments losing ground in China? A concerning trend emerges
A report from China indicates increasing prevalence of antibiotic-resistant strains of Neisseria gonorrhoeae.
A new report from China shows that medicines used to cure gonorrhea are losing their effectiveness as bacteria become more resistant to anti…
CDC Apr 4, 2026
CDC recommends doxycycline postexposure prophylaxis for high-risk populations to prevent syphilis, chlamydia, and gonorrhea
Infectious Disease
CDC recommends doxycycline postexposure prophylaxis for high-risk populations to prevent syphilis, chlamydia, and gonorrhea CDC now recommends a pill after sex to help prevent common STIs
The CDC has issued clinical guidelines recommending doxycycline postexposure prophylaxis (doxy PEP) for populations at high risk for syphili…
CDC now recommends a single antibiotic pill after sex to help prevent syphilis, chlamydia, and gonorrhea in high-risk groups.
CDC Apr 4, 2026

Questions about Gonorrhea

Can doxycycline be used to prevent infection after exposure to Gonorrhea?

Yes, doxycycline taken within 72 hours after sex can reduce the risk of gonorrhea infection in men who have sex with men and transgender women, but it is not effective in cisgender women.

Full answer →
Which antibiotics show high resistance for Gonorrhea in Kenya?

In Kenya, Neisseria gonorrhoeae shows very high resistance to tetracycline, ciprofloxacin, and penicillin.

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Is there antibiotic resistance in Gonorrhea strains found in China?

Antibiotic-resistant strains of Neisseria gonorrhoeae are increasing in prevalence within China.

Full answer →