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Home › Medications › esomeprazole

esomeprazole

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of esomeprazole

41 trials tracked of esomeprazole: 24 in phase 3 or 4 and 2 with published results. The most-cited published study has 18 citations.

41Trials tracked
24Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 5 Phase 3 19 Phase 2 6 Phase 1 8 Other / NA 3
  1. Phase 3 Stress Ulcer Prophylaxis of Intravenous Esomeprazole in Chinese Seriously Ill Patients Completed · 18 cited
  2. Phase 3 A Study to Evaluate the Efficacy and Safety of Bismuth-Containing Quadruple Therapy With Oral Vonoprazan (TAK-438) 20 mg Compared to Esomeprazole 20 mg Twice Daily in Paticipants With Helicobacter Pylori Infection Completed · 6 cited
  3. Phase 4 Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US Completed
  4. Phase 4 Esomeprazole Treatment Co-diagnosed Non Erosive Reflux Disease (NERD) and Chronic Gastritis Patients Completed
  5. Phase 4 A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg Completed
  6. Phase 4 The Utility of Nexium in Chronic Cough and Reflux Disease Completed
Show 35 more trials
  1. Phase 4 The Effect of Protein on Calcium Absorption and Gastric Acid Production Completed
  2. Phase 3 Phase 3 Study to Evaluate the Acid-Inhibitory Effect of Multiple Oral Doses of Vonoprazan (TAK-438) Completed
  3. Phase 3 A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia Completed
  4. Phase 3 Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Mild to Moderate Erosive Gastroesophageal Reflux Disease (GERD) Completed
  5. Phase 3 Efficacy of Esomeprazole in Patients With Frequent Heartburn Completed
  6. Phase 3 The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis Completed
  7. Phase 3 Efficacy of Esomeprazole in Patients With Frequent Heartburn Completed
  8. Phase 3 A Study to Prevent Rebleeding After Initial Successful Primary Endoscopic Haemostasis of a Bleeding Peptic Ulcer Completed
  9. Phase 3 Reflux Esophagitis Phase III Study (Initial Treatment) Completed
  10. Phase 3 Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAID Completed
  11. Phase 3 Esomeprazole (NEXIUM) vs. Surgery Completed
  12. Phase 3 Rabeprazole Extended-Release, 50 mg, Versus Esomeprazole, 40 mg, for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD) Completed
  13. Phase 3 Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-induced Gastric Ulcer Completed
  14. Phase 3 Study of Acid Reflux in Asthma Completed
  15. Phase 3 Comparative Efficacy & Safety Study of D961H Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With Low-dose Aspirin Completed
  16. Phase 3 Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal Patients Completed
  17. Phase 3 Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD) Completed
  18. Phase 3 Reflux Esophagitis Phase III Study (Maintenance Treatment) Completed
  19. Phase 2 Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer Completed
  20. Phase 2 Comparison of Vonoprazan to Esomeprazole in Participants With Symptomatic GERD Who Responded Partially to a High Dose of Proton Pump Inhibitor (PPI) Completed
  21. Phase 2 Effect of Proton Pump Inhibitors on CF Pulmonary Exacerbations Completed
  22. Phase 2 Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD Patients Completed
  23. Phase 2 Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma Completed
  24. Phase 2 A Study Evaluating the Effect of Esomeprazole on SYN-004 Degradation of Ceftriaxone In Adults With an Ileostomy Completed
  25. Phase 1 A Trial to Evaluate the Effect of the Proton Pump Inhibitor Esomeprazole on the Single-dose Pharmacokinetics (PK) of Oral TAK-906 in Healthy Adult Participants Completed
  26. Phase 1 A Study to Investigate the Effect of Esomeprazole and the Effect of Food on the Pharmacokinetics of Balovaptan in Healthy Volunteers Completed
  27. Phase 1 A Study to Assess the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics (PK) of TAK-931 in Participants With Advanced Solid Tumors Completed
  28. Phase 1 A Study of Vonoprazan in Adults With Helicobacter Pylori Completed
  29. Phase 1 Safety, Tolerability and Pharmacokinetic (PK) of Concomitant Esomeprazole and Rifampin, and QT Study on Single and Multiple-doses of Alisertib Completed
  30. Phase 1 A Study Investigating the Effect of Food and Esomeprazole on the Single Oral Dose Pharmacokinetics of Alectinib (RO5424802) in Healthy Volunteers. Completed
  31. Phase 1 A Multiple Dose Study of LY3502970 in Healthy Participants Completed
  32. Phase 1 Effect of Dexlansoprazole on Bone Homeostasis Completed
  33. N/A Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of Patients On and Off Proton Pump Inhibitor Therapy Completed
  34. N/A Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial Completed
  35. N/A Fluticasone Versus Esomeprazole to Treat Eosinophilic Esophagitis Completed

Showing the 41 most-cited and recently-updated of 41 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Omeprazole, rabeprazole, pantoprazole, and lansoprazole are associated with increased fracture risk in elderly patients
Drug Pipeline Meta-analysis
Omeprazole, rabeprazole, pantoprazole, and lansoprazole are associated with increased fracture risk in elderly patients Some acid reflux medications may increase fracture risk in seniors
This network meta-analysis of 257,445 patients indicates that omeprazole, rabeprazole, pantoprazole, and lansoprazole are associated with in…
New data suggests that certain acid reflux medications may increase the risk of bone fractures for adults over age 65.
Frontiers Sep 13, 2026
Keverprazan-amoxicillin dual therapy shows non-inferior H. pylori eradication versus esomeprazole-amoxicillin
Infectious Disease RCT
Keverprazan-amoxicillin dual therapy shows non-inferior H. pylori eradication versus esomeprazole-amoxicillin New drug shows promise for treating H. pylori infections
This prospective, multicenter randomized controlled trial in 264 treatment-naive adults with H. pylori infection found that 14-day keverpraz…
A new treatment combination showed higher success rates at clearing H. pylori bacteria compared to a standard medication.
Aug 11, 2026
H. pylori eradication reduces cholesterol and LDL in patients with cardiovascular disease risk
Infectious Disease RCT
H. pylori eradication reduces cholesterol and LDL in patients with cardiovascular disease risk Treating This Stomach Bug May Quietly Lower Heart Risk
A randomized controlled trial in 72 patients with H.
Treating a common stomach infection can lower cholesterol and small dense lipoprotein particles a year later, potentially reducing heart dis…
Apr 15, 2026