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Home › Medications › linezolid

linezolid

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of linezolid

31 trials tracked of linezolid: 16 in phase 3 or 4 and 10 with published results. The most-cited published study has 1025 citations.

31Trials tracked
16Phase 3 & 4
0Recruiting
10With published results
Phase distribution
Phase 4 1 Phase 3 15 Phase 2 11 Phase 1 1 Other / NA 3
  1. Phase 3 A Phase 3 Trial Assessing Safety and Efficacy of B-Pa-L in Participants With DR-TB Completed · 1,025 cited
  2. Phase 3 Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis Completed · 557 cited
  3. Phase 3 Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogens Completed · 457 cited
  4. Phase 3 Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014) Completed · 223 cited
  5. Phase 3 Study to Compare Lefamulin to Moxifloxacin (With or Without Linezolid) for the Treatment of Adults With Pneumonia Completed · 142 cited
  6. Phase 3 Oral Omadacycline vs. Oral Linezolid for the Treatment of ABSSSI Completed · 94 cited
Show 25 more trials
  1. Phase 3 Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002) Completed · 56 cited
  2. Phase 3 Efficacy and Safety of Intravenous to Oral 6-Day Tedizolid Phosphate vs. Intravenous to Oral 10-Day Linezolid in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI) Completed · 48 cited
  3. Phase 3 Omadacycline Versus Linezolid for the Treatment of ABSSSI (EudraCT #2013-003644-23) Completed · 45 cited
  4. Phase 3 Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia (MK-7655A-016) Completed · 8 cited
  5. Phase 4 Skin Structure Infections With Suspected or Proven Methicillin-Resistant Staphylococcus Aureus (MRSA) Completed
  6. Phase 3 Safety and Efficacy of BAY1192631 in Japanese Patients With Methicillin-resistant Staphylococcus Aureus (MRSA) Infections Completed
  7. Phase 3 Study to Compare Delafloxacin to Moxifloxacin for the Treatment of Adults With Community-acquired Bacterial Pneumonia Completed
  8. Phase 3 TR-701 FA vs. Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections. Completed
  9. Phase 3 TR-701 FA vs Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections Completed
  10. Phase 3 Retapamulin Versus Linezolid in the Treatment of SITL and Impetigo Due to MRSA Completed
  11. Phase 2 Treatment Shortening of MDR-TB Using Existing and New Drugs Completed
  12. Phase 2 Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis Completed
  13. Phase 2 GSK1322322 Versus Linezolid in the Treatment of Acute Bacterial Skin and Skin Structure Infection Completed
  14. Phase 2 Pharmacokinetics of Linezolid in Children With Cystic Fibrosis Completed
  15. Phase 2 Study of Debio 1450 for Bacterial Skin Infections Completed
  16. Phase 2 A Study to Assess Objective Endpoint Measurements of Response in Bacterial Skin Infections Completed
  17. Phase 2 MRX-I Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection Completed
  18. Phase 2 PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN Completed
  19. Phase 2 Efficacy and Safety of Ceftaroline Versus Linezolid in Subjects With Complicated Skin and Skin Structure Infections Completed
  20. Phase 2 Safety and Efficacy Study of Oxazolidinones to Treat Uncomplicated Skin Infections Completed
  21. Phase 2 Study the Efficacy and Safety of PTK 0796 in Patients With Complicated Skin and Skin Structure Infection (CSSSI) Completed
  22. Phase 1 Bioequivalence Study Comparing Linezolid 600 Mg Oral Suspension With 600 Mg Tablet In Chinese Healthy Male Subjects Completed
  23. N/A Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin Completed
  24. N/A Post Marketing Surveillance Study on Linezolid Completed
  25. N/A Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Quadruple antimycobacterial regimen achieves clinical stability in cystic fibrosis patient with M. abscessus
Pediatrics Sys. Review
Quadruple antimycobacterial regimen achieves clinical stability in cystic fibrosis patient with M. abscessus Case report shows quadruple regimen for cystic fibrosis infection
A case report and literature review describes a 21-year-old man with cystic fibrosis and Mycobacterium abscessus infection who achieved clin…
A young man with cystic fibrosis and a hard-to-treat infection achieved stability using a four-drug antimycobacterial regimen.
Frontiers Jun 2, 2026
Meta-analysis shows linezolid-containing regimens for multidrug/rifampicin-resistant tuberculosis
Infectious Disease Meta-analysis
Meta-analysis shows linezolid-containing regimens for multidrug/rifampicin-resistant tuberculosis Linezolid helps treat drug resistant tuberculosis
This meta-analysis of 3019 patients evaluates the efficacy and safety of linezolid-containing regimens compared to standard of care for…
New evidence shows that adding linezolid to treatment helps patients with drug resistant tuberculosis achieve better health outcomes.
May 1, 2026
Molecular epidemiology study of rifampicin-resistant TB in Vietnam shows high resistance to other drugs
Infectious Disease
Molecular epidemiology study of rifampicin-resistant TB in Vietnam shows high resistance to other drugs Vietnam’s TB Crisis Hides a Dangerous Pattern
This molecular epidemiology study analyzed 252 rifampicin-resistant TB isolates from Vietnam using whole genome sequencing.
A hidden pattern in Vietnam’s tuberculosis cases reveals most drug-resistant strains also resist other key medicines, changing how doctors m…
medRxiv Apr 27, 2026
Retrospective cohort study examines MRSA prevalence and resistance patterns in nosocomial bloodstream infections among 96 patients in central China
Primary Care & Family Medicine Cohort
Retrospective cohort study examines MRSA prevalence and resistance patterns in nosocomial bloodstream infections among 96 patients in central China Are hospital infections getting harder to treat, or is the data stable?
This retrospective cohort study analyzed 96 Staphylococcus aureus isolates from patients with nosocomial bloodstream infections at a tertiar…
Hospital bloodstream infections from tough MRSA bacteria stayed stable in frequency, but one patient's germ was resistant to the last-resort…
Frontiers Apr 14, 2026
Contezolid Shows Lower CSF Concentrations Than Linezolid in Tuberculous Meningitis
Infectious Disease RCT
Contezolid Shows Lower CSF Concentrations Than Linezolid in Tuberculous Meningitis New Drug Reaches Brain in Tuberculosis Fight
A small randomized study in 10 tuberculous meningitis patients compared CSF concentrations of contezolid versus linezolid.
A new tuberculosis drug reaches the brain effectively and safely, offering hope for the deadliest form of the infection.
Apr 11, 2026
Linezolid vs clindamycin shows no ICU or hospital stay difference in severe SSTIs
Infectious Disease Meta-analysis
Linezolid vs clindamycin shows no ICU or hospital stay difference in severe SSTIs For severe skin infections, does one antibiotic keep you out of the hospital longer?
A systematic review and meta-analysis of patients with severe or necrotizing skin and soft tissue infections found no significant difference…
For severe skin infections, using linezolid instead of clindamycin does not help patients leave the hospital faster, though it may lower kid…
Apr 2, 2026