Case report review: BPaLM for MDR-TB with cerebral or bone involvement shows mixed outcomes
New Drug Regimen Shows Promise For Rare Bone And Brain TB Cases
This review of a case report describes two patients with multidrug-resistant tuberculosis (MDR-TB) involving cerebral or bone sites treated …
A new short drug combo cleared bone and brain TB in one patient but side effects stopped treatment for another.
Systematic review and meta-analysis of MDR-TB prevalence in the MENA region
TB drug resistance in Middle East and North Africa
This meta-analysis of 25 studies from 6 countries synthesized the prevalence of multidrug-resistant tuberculosis in the MENA region. The poo…
A review of 25 studies found about 3.5% of TB patients in the region have drug-resistant strains. The findings highlight a need for stronger…
Meta-analysis shows linezolid-containing regimens for multidrug/rifampicin-resistant tuberculosis
Linezolid helps treat drug resistant tuberculosis
This meta-analysis of 3019 patients evaluates the efficacy and safety of linezolid-containing regimens compared to standard of care for…
New evidence shows that adding linezolid to treatment helps patients with drug resistant tuberculosis achieve better health outcomes.
Adjunctive Yuehua Decoction linked to improved quality of life in multidrug-resistant TB patients
A Traditional Herb May Ease the Burden of Drug-Resistant TB
This prospective cohort study in adults with multidrug-resistant tuberculosis found that adjunctive Yuehua Decoction with standard chemother…
This study suggests a traditional Chinese medicine could improve quality of life for patients battling drug-resistant tuberculosis, with few…
R3clone strain accounts for 70% of rifampicin-resistant TB in Rwanda and transmits across borders
How One Drug-Resistant TB Strain Quietly Crossed African Borders
This observational study analyzed 375 Mycobacterium tuberculosis isolates from Rwanda, Burundi, and public repositories.
Genomic surveillance shows that a dominant drug-resistant TB strain causing most cases in Rwanda has been quietly spreading across borders i…
Three Cases of Multidrug-Resistant Tuberculosis Identified Among Ohio Food Processing Workers
Three workers at Ohio food plants have drug-resistant tuberculosis. What does this mean?
A field investigation report describes a case series of 3 workers at two Ohio food processing facilities diagnosed with multidrug-resistant …
Three Ohio food plant workers have drug-resistant tuberculosis, a hard-to-treat infection that requires more investigation to understand the…
Outbreak report describes multidrug-resistant tuberculosis cases in Kansas
Health officials report multidrug-resistant tuberculosis outbreak in Kansas
An outbreak report describes cases of multidrug-resistant tuberculosis in Kansas.
Kansas health officials report an outbreak of multidrug-resistant tuberculosis that does not respond to common antibiotics.
Research across Tuberculosis
Related studies from across the Tuberculosis family.
Video observed therapy improves treatment success and adherence in adults with tuberculosis
Digital Tools Show Better Success Rates for Tuberculosis Treatment
This network meta-analysis of 29 randomized controlled trials evaluated digital health interventions for tuberculosis. Video observed therap…
Video observed therapy shows higher success and adherence rates for patients with tuberculosis compared to traditional face-to-face methods.
Water buffalo act as reservoirs for infectious diseases in mixed livestock systems
Water Buffalo May Spread Diseases to Other Livestock
This systematic review analyzes 180 articles regarding infectious diseases in water buffalo. The authors conclude that these animals are inc…
A review of 180 articles suggests water buffalo act as disease reservoirs, meaning they can pass infections to other animals in mixed farmin…
HIV linked to lower odds of post-TB lung disease; undernutrition raises risk
Undernutrition and HIV may lower or raise lung damage risk after tuberculosis in low-income nations
This systematic review and meta-analysis of 41 studies in LMICs found that HIV was associated with reduced odds of spirometry-defined post-t…
New analysis of data from low-income countries shows mixed results on how HIV, diabetes, and poor nutrition affect lung health after tubercu…
Immediate antituberculosis therapy did not reduce mortality in HIV-related sepsis overall
Immediate TB treatment helps only those with confirmed infection in HIV sepsis
This trial investigated whether starting antituberculosis treatment immediately or using high doses improved survival in adults with HIV-rel…
In HIV sepsis, starting TB drugs immediately did not lower death rates overall, but helped only patients later confirmed to have TB.
Ethambutol optic neuropathy incidence 1.54 percent with renal impairment and hypertension as key risk factors
Kidney disease and high blood pressure raise risk of vision loss from TB drug
This systematic review and meta-analysis synthesized evidence on ethambutol optic neuropathy and tuberculous meningitis complications. The p…
A massive review of over 260,000 patients found that kidney problems and high blood pressure make vision loss from the TB drug ethambutol mu…
Narrative review on vitamin D and VDR in gastrointestinal and pulmonary diseases
Vitamin D's Role in Gut and Lung Health Examined
This narrative review synthesizes evidence on vitamin D deficiency and VDR expression across gastrointestinal and pulmonary conditions. The …
A review explores how vitamin D deficiency and VDR expression may influence digestive and respiratory diseases, but more research is needed.
Meta-analysis of dolutegravir-based ART and risk-stratified HIV care in Uganda
HIV Treatment Works Better Now, But One Problem Remains
This meta-analysis and cohort review examined viral non-suppression rates among people with HIV in Uganda receiving dolutegravir-based ART. …
New HIV drugs are highly effective, yet thousands of patients in Uganda still have uncontrolled virus, and a fresh approach using routine da…
Expert consensus guidelines for N-acetylcysteine use in various respiratory conditions
Experts share new guidance on using N-acetylcysteine for lung health
This expert consensus guideline reviews the clinical utility of N-acetylcysteine (NAC) across several respiratory diseases. The authors sugg…
Medical experts have reached a consensus on how a specific supplement might help people managing various chronic lung diseases.
Digital chest radiography with CAD shows variable sensitivity for asymptomatic tuberculosis in South African adults
Digital scans miss many silent tuberculosis cases in South Africa adults
This cohort study evaluated digital chest radiography (dCXR) read by blinded human readers and qXR CAD in 1353 adults in South Africa.
New data from South Africa shows digital scans and computer tools miss many silent tuberculosis cases, raising questions about current scree…
Observational study assesses MiniDock MTB diagnostic accuracy against Xpert in Indonesian TB patients
New TB test shows promise in Indonesia trial
This observational study evaluated the diagnostic accuracy of MiniDock MTB on sputum swabs compared to Xpert MTB/RIF Ultra and liquid cultur…
A new TB test called MiniDock MTB accurately detected TB in adults, but sensitivity dropped in children and low-burden cases.
High-dose rifampicin pharmacokinetics differ across sites in tuberculosis infection randomized trial
High-dose rifampicin shows different drug levels in adults across three countries
This randomized controlled trial evaluated adults and adolescents aged ≥ 10 years with tuberculosis infection.
Drug levels of high-dose rifampicin varied by country, with lower bioavailability seen in Canada and Vietnam compared to Indonesia in this t…
MiniDock MTB Test Shows High Sensitivity and Specificity for Tuberculosis Detection
A new test finds TB in people who cough up nothing
This prospective cross-sectional study evaluated the MiniDock MTB test using sputum and tongue swabs in 1380 patients with presumptive pulmo…
A new test found tuberculosis in over 85% of patients who could not produce a cough sample, offering a faster way to diagnose the disease in…