HIV co-infection triples MDR-TB mortality risk; low BMI and anaemia also raise risk
HIV and other risk factors linked to multidrug-resistant tuberculosis deaths
This meta-analysis of 36,693 patients with multidrug-resistant tuberculosis (MDR-TB) found that HIV co-infection, lower educational attainme…
Patients with multidrug-resistant tuberculosis face higher risks of death if they also have HIV, low body mass index, or certain other healt…
Multidrug-resistant tuberculosis prevalence is 5.2% among patients with bacteriologically confirmed cases in Cameroon
Identifying key risks for drug resistant tuberculosis infections in Cameroon
This meta-analysis of 28 studies involving 9,931 patients identifies a 5.2% pooled prevalence of multidrug-resistant tuberculosis (MDR-TB) i…
New data shows that past infections and lifestyle factors like alcohol use can increase the risk of developing hard-to-treat tuberculosis.
Case report review: BPaLM for MDR-TB with cerebral or bone involvement shows mixed outcomes
New Drug Regimen Shows Promise For Rare Bone And Brain TB Cases
This review of a case report describes two patients with multidrug-resistant tuberculosis (MDR-TB) involving cerebral or bone sites treated …
A new short drug combo cleared bone and brain TB in one patient but side effects stopped treatment for another.
Systematic review and meta-analysis of MDR-TB prevalence in the MENA region
TB drug resistance in Middle East and North Africa
This meta-analysis of 25 studies from 6 countries synthesized the prevalence of multidrug-resistant tuberculosis in the MENA region. The poo…
A review of 25 studies found about 3.5% of TB patients in the region have drug-resistant strains. The findings highlight a need for stronger…
Meta-analysis shows linezolid-containing regimens for multidrug/rifampicin-resistant tuberculosis
Linezolid helps treat drug resistant tuberculosis
This meta-analysis of 3019 patients evaluates the efficacy and safety of linezolid-containing regimens compared to standard of care for…
New evidence shows that adding linezolid to treatment helps patients with drug resistant tuberculosis achieve better health outcomes.
Adjunctive Yuehua Decoction linked to improved quality of life in multidrug-resistant TB patients
A Traditional Herb May Ease the Burden of Drug-Resistant TB
This prospective cohort study in adults with multidrug-resistant tuberculosis found that adjunctive Yuehua Decoction with standard chemother…
This study suggests a traditional Chinese medicine could improve quality of life for patients battling drug-resistant tuberculosis, with few…
R3clone strain accounts for 70% of rifampicin-resistant TB in Rwanda and transmits across borders
How One Drug-Resistant TB Strain Quietly Crossed African Borders
This observational study analyzed 375 Mycobacterium tuberculosis isolates from Rwanda, Burundi, and public repositories.
Genomic surveillance shows that a dominant drug-resistant TB strain causing most cases in Rwanda has been quietly spreading across borders i…
Three Cases of Multidrug-Resistant Tuberculosis Identified Among Ohio Food Processing Workers
Three workers at Ohio food plants have drug-resistant tuberculosis. What does this mean?
A field investigation report describes a case series of 3 workers at two Ohio food processing facilities diagnosed with multidrug-resistant …
Three Ohio food plant workers have drug-resistant tuberculosis, a hard-to-treat infection that requires more investigation to understand the…
Outbreak report describes multidrug-resistant tuberculosis cases in Kansas
Health officials report multidrug-resistant tuberculosis outbreak in Kansas
An outbreak report describes cases of multidrug-resistant tuberculosis in Kansas.
Kansas health officials report an outbreak of multidrug-resistant tuberculosis that does not respond to common antibiotics.
Research across Tuberculosis
Related studies from across the Tuberculosis family.
Risk prediction models for anti-tuberculosis drug-induced liver injury show pooled AUC of 0.81
Risk Prediction Models Help Identify Liver Damage from Tuberculosis Drugs
This meta-analysis of 26 studies involving 41,734 cases evaluated risk prediction models for anti-tuberculosis drug-induced liver injury (AT…
New risk models can help identify patients at risk for liver injury when taking tuberculosis medications, especially those with specific hea…
Sensititre MYCOTB shows high diagnostic accuracy for rifampicin and isoniazid in tuberculosis isolates
New test shows high accuracy for detecting drug resistant tuberculosis
This meta-analysis of 1,728 isolates evaluates the diagnostic performance of Sensititre MYCOTB against reference drug susceptibility testing…
A new testing method shows high accuracy in identifying which drugs can successfully treat drug-resistant tuberculosis infections.
Bronchoscopic resection and individualized therapy may treat tracheobronchial tuberculosis presenting as endobronchial masses
Rare airway tuberculosis found in young man's bronchial mass
This case report and literature review describes a 21-year-old male with tumorous tracheobronchial tuberculosis complicated by infiltrative …
A 21-year-old's airway mass turned out to be a rare form of tuberculosis. Early removal and treatment led to marked improvement.
Expanded TB Screening in HIV Inpatients Shows No Benefit
Expanded Screening Does Not Speed Tuberculosis Treatment for HIV Patients
In HIV-positive hospital inpatients, expanded TB screening with Xpert Ultra and LF-LAM did not improve treatment initiation or 8-week mortal…
A large trial in Tanzania and Mozambique found that expanded screening did not speed up tuberculosis treatment or reduce deaths for patients…
Tuberculosis prevalence among children with severe acute malnutrition is 13% (95% CI: 11-16%)
Tuberculosis is common among children with severe acute malnutrition
This meta-analysis of 33,869 children across 15 countries identifies a pooled tuberculosis prevalence of 13% in those with severe acute maln…
Over 13% of children suffering from severe acute malnutrition also have tuberculosis, highlighting a critical need for integrated screening.
WGS-based tools provide high specificity and sensitivity for rifampicin, isoniazid, and fluoroquinolone resistance detection
New tools help doctors identify drug resistant tuberculosis strains
This meta-analysis of 144,623 M. tuberculosis genomes evaluates six open-access WGS-based drug susceptibility testing prediction tools. The …
New computer tools can accurately predict if common drugs will work against tuberculosis, helping doctors choose the right treatment faster.
Pulmonary TB History Linked to Higher COPD Odds
Past tuberculosis infection significantly increases risk of developing lung disease
Meta-analysis of over 1 million people finds prior pulmonary TB associated with 2.65 times higher odds of COPD.
A history of pulmonary tuberculosis is linked to a much higher risk of developing chronic obstructive pulmonary disease, especially in certa…
TB-TST mobile application increases treatment success to 82% in drug susceptible tuberculosis
Mobile App Improves Success Rates for Tuberculosis Treatment
This pragmatic randomized controlled trial of 555 individuals with newly diagnosed drug susceptible tuberculosis found that the TB-TST inter…
A mobile app and urine tests helped more patients complete their tuberculosis treatment compared to standard care alone.
Modified regimens for drug-resistant tuberculosis show higher success rates than standard regimens in Cameroon
Modified drug regimens show higher success for drug-resistant tuberculosis
This systematic review and meta-analysis of 2,351 patients with drug-resistant tuberculosis (DR-TB) in Cameroon found that modified regimens…
A new analysis shows modified treatment plans can improve success rates for patients fighting drug-resistant tuberculosis.
Baseline auramine count predicts tuberculosis failure or relapse by 5% higher odds per 100 bacilli
Auramine Levels May Predict Treatment Success for Tuberculosis Patients
This secondary analysis of an RCT involving 321 patients treated with double-dose R. found that quantitative baseline auramine significantly…
A study suggests that specific bacteria counts at the start of treatment can help predict if a patient with tuberculosis will experience a r…
Rifapentine 15 mg/kg and 20 mg/kg yield higher culture conversion than standard 6-month regimen
Trial Shows Rifapentine Dosage Impacts Tuberculosis Treatment Outcomes
This Phase 2/3 Stage 1 randomized controlled trial of 400 adults with pulmonary drug-susceptible tuberculosis compared three 4-month rifapen…
A new clinical trial explores how different doses of rifapentine affect treatment success and safety for patients with drug-susceptible tube…
Shorter rifamycin-containing regimens show comparable efficacy to longer isoniazid monotherapy for latent tuberculosis infection
Shorter drug plans may help children finish tuberculosis treatments
This meta-analysis evaluated shorter rifamycin-containing regimens against a nine-month isoniazid course in children with latent tuberculosi…
New data suggests shorter treatment plans for latent tuberculosis can help children complete their medication without increasing the risk of…