HIV co-infection triples MDR-TB mortality risk; low BMI and anaemia also raise risk
HIV and other risk factors linked to multidrug-resistant tuberculosis deaths
This meta-analysis of 36,693 patients with multidrug-resistant tuberculosis (MDR-TB) found that HIV co-infection, lower educational attainme…
Patients with multidrug-resistant tuberculosis face higher risks of death if they also have HIV, low body mass index, or certain other healt…
Multidrug-resistant tuberculosis prevalence is 5.2% among patients with bacteriologically confirmed cases in Cameroon
Identifying key risks for drug resistant tuberculosis infections in Cameroon
This meta-analysis of 28 studies involving 9,931 patients identifies a 5.2% pooled prevalence of multidrug-resistant tuberculosis (MDR-TB) i…
New data shows that past infections and lifestyle factors like alcohol use can increase the risk of developing hard-to-treat tuberculosis.
Case report review: BPaLM for MDR-TB with cerebral or bone involvement shows mixed outcomes
New Drug Regimen Shows Promise For Rare Bone And Brain TB Cases
This review of a case report describes two patients with multidrug-resistant tuberculosis (MDR-TB) involving cerebral or bone sites treated …
A new short drug combo cleared bone and brain TB in one patient but side effects stopped treatment for another.
Systematic review and meta-analysis of MDR-TB prevalence in the MENA region
TB drug resistance in Middle East and North Africa
This meta-analysis of 25 studies from 6 countries synthesized the prevalence of multidrug-resistant tuberculosis in the MENA region. The poo…
A review of 25 studies found about 3.5% of TB patients in the region have drug-resistant strains. The findings highlight a need for stronger…
Meta-analysis shows linezolid-containing regimens for multidrug/rifampicin-resistant tuberculosis
Linezolid helps treat drug resistant tuberculosis
This meta-analysis of 3019 patients evaluates the efficacy and safety of linezolid-containing regimens compared to standard of care for…
New evidence shows that adding linezolid to treatment helps patients with drug resistant tuberculosis achieve better health outcomes.
Adjunctive Yuehua Decoction linked to improved quality of life in multidrug-resistant TB patients
A Traditional Herb May Ease the Burden of Drug-Resistant TB
This prospective cohort study in adults with multidrug-resistant tuberculosis found that adjunctive Yuehua Decoction with standard chemother…
This study suggests a traditional Chinese medicine could improve quality of life for patients battling drug-resistant tuberculosis, with few…
R3clone strain accounts for 70% of rifampicin-resistant TB in Rwanda and transmits across borders
How One Drug-Resistant TB Strain Quietly Crossed African Borders
This observational study analyzed 375 Mycobacterium tuberculosis isolates from Rwanda, Burundi, and public repositories.
Genomic surveillance shows that a dominant drug-resistant TB strain causing most cases in Rwanda has been quietly spreading across borders i…
Three Cases of Multidrug-Resistant Tuberculosis Identified Among Ohio Food Processing Workers
Three workers at Ohio food plants have drug-resistant tuberculosis. What does this mean?
A field investigation report describes a case series of 3 workers at two Ohio food processing facilities diagnosed with multidrug-resistant …
Three Ohio food plant workers have drug-resistant tuberculosis, a hard-to-treat infection that requires more investigation to understand the…
Outbreak report describes multidrug-resistant tuberculosis cases in Kansas
Health officials report multidrug-resistant tuberculosis outbreak in Kansas
An outbreak report describes cases of multidrug-resistant tuberculosis in Kansas.
Kansas health officials report an outbreak of multidrug-resistant tuberculosis that does not respond to common antibiotics.
Research across Tuberculosis
Related studies from across the Tuberculosis family.
Meta-analysis-guided sampling plan targets 14 zoonotic and animal diseases across India
New sampling plan helps track diseases jumping from animals to humans
This meta-analysis pools prevalence estimates for 10 zoonotic and 4 transboundary animal diseases in India, reporting a range of 4 to 30% ac…
A new plan for monitoring animal diseases in India helps track infections like Q-fever and scrub typhus before they spread to people.
Multi-scale computational methods identify pivotal tuberculosis vulnerabilities and predict drug resistance with high fidelity
Computational Methods Identify New Targets for Tuberculosis Treatment
This systematic review evaluates multi-scale computational methods including machine learning and molecular dynamics for tuberculosis drug d…
New computer modeling techniques are identifying key targets and predicting drug resistance to help speed up the development of tuberculosis…
Host-directed therapy including metformin and statins may modulate immune response in tuberculosis patients
Repurposed Drugs Like Metformin May Help Fight Tuberculosis
This narrative review explores host-directed therapy (HDT) as an adjunctive strategy to modulate immune responses and limit immunopathology …
New research explores how host-directed therapies, including common drugs like metformin and statins, could help the body fight tuberculosis…
3HP with SMS reminders increases treatment completion to 84.9% compared to 65.4% for 4RIF
SMS reminders help more people finish tuberculosis treatment
This randomized controlled trial of 210 individuals with tuberculosis infection found that 3HP with SMS reminders resulted in a higher treat…
A new trial shows that a shorter treatment plan paired with text message reminders helps more people finish their tuberculosis medication.
Tobacco smoking history increases odds of antibiotic-resistant infections including tuberculosis-related resistance
Tobacco smoking increases risk of antibiotic-resistant bacterial infections
This meta-analysis of more than 35,000 participants indicates that tobacco smoking history is associated with higher odds of antibiotic-resi…
A large review of over 35,000 people shows that a history of smoking significantly increases the risk of developing drug-resistant infection…
Pre-XDR-TB affects 3% and XDR-TB 1% of MDR-TB patients in Ethiopia
Drug-Resistant TB Strains Affect 4% of Ethiopian MDR-TB Patients
This meta-analysis estimates the prevalence of pre-extensively drug-resistant (Pre-XDR-TB) and extensively drug-resistant tuberculosis (XDR-…
About 4 in 100 MDR-TB patients in Ethiopia also carry harder-to-treat TB strains, a new analysis finds.
Gestational HIV exposure does not increase tuberculosis disease risk in children who are HIV-exposed uninfected
Comparing Tuberculosis Risk in Children Exposed to HIV During Pregnancy
This meta-analysis of 18 studies evaluated tuberculosis risk in children who are HIV-exposed uninfected (cHEU) compared to HIV-unexposed uni…
New data shows that children exposed to HIV before birth have similar tuberculosis risks as children never exposed.
Community health workers support infectious disease management and PrEP navigation in agricultural communities
Community health workers help farm workers manage infectious diseases
This mini-review examines the role of community health workers (CHWs) in managing infectious diseases among California agricultural workers.…
Community health workers can help farm workers manage serious infections like HIV, tuberculosis, and hepatitis through direct outreach and n…
Short course regimens 3HP, 4HR, and 4R show higher adherence and lower active cases than 9H
Short Treatment Courses May Reduce Tuberculosis Cases in Children
This network meta-analysis evaluates treatment regimens for children and adolescents with TB infection. The study finds that 4HR reduces act…
New analysis suggests shorter drug regimens for children with tuberculosis may improve treatment completion and reduce the number of active …
Mtb antigen-induced IP-10 shows pooled sensitivity 0.81 and specificity 0.88 for latent TB
New Blood Test Marker Shows Promise for Detecting Hidden Tuberculosis Infections
This meta-analysis of 24 studies (2,014 participants) evaluated Mycobacterium tuberculosis antigen-induced interferon-gamma-inducible protei…
A new protein marker in the blood helps doctors identify people with hidden tuberculosis infections more accurately.
Comprehensive pulmonary rehabilitation may improve exercise capacity and quality of life in post-tuberculosis lung disease
Comprehensive Pulmonary Rehabilitation May Improve Life After Tuberculosis
This narrative review examines the role of comprehensive pulmonary rehabilitation for individuals with post-tuberculosis lung disease. The a…
Comprehensive pulmonary rehabilitation programs may improve exercise capacity and quality of life for people living with lung disease after …
Fluoroquinolone resistance acquired more frequently during TB treatment than other anti-TB drugs
Bacteria develop resistance to fluoroquinolones more often during tuberculosis treatment
This meta-analysis analyzed 5882 high-quality genomes from 1044 patients to identify MTBC mutations during infection and treatment. It found…
New data shows that tuberculosis bacteria develop resistance to fluoroquinolones more frequently than any other drug during treatment.