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Home › Medications › Naproxen

Naproxen

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials of Naproxen

53 trials tracked of Naproxen: 30 in phase 3 or 4 and 17 with published results. The most-cited published study has 189 citations.

53Trials tracked
30Phase 3 & 4
0Recruiting
17With published results
Phase distribution
Phase 4 19 Phase 3 11 Phase 2 17 Phase 1 3 Other / NA 3
  1. Phase 4 A Randomized Study of Three Medication Regimens for Acute Low Back Pain Completed · 189 cited
  2. Phase 3 Tanezumab In Osteoarthritis Of The Knee (2) Completed · 86 cited
  3. Phase 3 Tanezumab in Osteoarthritis of the Hip or Knee (2) Completed · 86 cited
  4. Phase 4 IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA Completed · 72 cited
  5. Phase 4 Treatment Study of Steroid Injection and Physical Therapy for Acute Lateral Epicondylitis Completed · 71 cited
  6. Phase 4 Orphenadrine and Methocarbamol for LBP Completed · 68 cited
Show 44 more trials
  1. Phase 4 MAST Trial: Multi-modal Analgesic Strategies in Trauma Completed · 52 cited
  2. Phase 4 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed · 40 cited
  3. Phase 3 Efficacy and Safety of Extended Release and Immediate Release Febuxostat in Participants With Gout Completed · 32 cited
  4. Phase 4 A Trial to Compare the Duration of Analgesic Efficacy and Safety of Naproxen Sodium Tablets and Ibuprofen Tablets in Postsurgical Dental Pain Completed · 29 cited
  5. Phase 4 Effect of L-dopa In Subacute Back Pain Population Completed · 23 cited
  6. Phase 4 A Study to Assess Menstrual Cramp Pain Associated With Primary Dysmenorrhea Completed · 20 cited
  7. Phase 4 Placebo In Chronic Back Pain - Double-Blind Randomized Control Trial Completed · 17 cited
  8. Phase 4 Placebo In Chronic Back Pain (Phase 2) Completed · 16 cited
  9. Phase 4 Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed Completed · 12 cited
  10. Phase 4 OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients Completed · 6 cited
  11. Phase 3 A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip Completed · 6 cited
  12. Phase 4 Trial of Comprehensive Migraine Intervention Completed
  13. Phase 4 Intensive Urate Lowering Therapy of Febuxostat Compared to Allopurinol on Cardiovascular Risk in Patients With Gout Completed
  14. Phase 4 Copper IUD Treatment Observation Study Completed
  15. Phase 4 Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain Completed
  16. Phase 4 A Study To Evaluate The Effects Of Celecoxib (Celebrex®) Or Naproxen On Blood Pressure In Pediatric Subjects Completed
  17. Phase 4 Comparing Naproxen to Sumatriptan for Emergency Headache Patients Completed
  18. Phase 3 Characterize Flu-like Symptoms in Relapsing Multiple Sclerosis Patients Transitioning From Non-Pegylated Interferon Beta (IFN-β) Therapies to Peginterferon Beta-1a (BIIB017) Completed
  19. Phase 3 Diazepam Use With Standard Management for Acute Low Back Pain Completed
  20. Phase 3 A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo Completed
  21. Phase 3 Prevention of Pegfilgrastim-Induced Bone Pain (PIBP) Completed
  22. Phase 3 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed
  23. Phase 3 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed
  24. Phase 3 Infliximab for Treatment of Axial Spondyloarthritis (P05336 AM1) Completed
  25. Phase 2 A Study of Tanezumab in Adults With Chronic Low Back Pain Completed
  26. Phase 2 Oral Bioequivalence Study of PL 3100 and Naproxen in Healthy Adults Completed
  27. Phase 2 Efficacy and Safety of Extended Release and Immediate Release Febuxostat in Participants With Gout and Moderate Renal Impairment Completed
  28. Phase 2 Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1940 Completed
  29. Phase 2 To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee Completed
  30. Phase 2 A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee Completed
  31. Phase 2 Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1) Completed
  32. Phase 2 A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034) Completed
  33. Phase 2 Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed Completed
  34. Phase 2 A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness Scale Completed
  35. Phase 2 Clinical Trial Evaluating Gastrointestinal Damage Following Administration PL3100 or Naproxen in At-Risk Adults Completed
  36. Phase 2 RN624 In Adult Patients With Chronic Low Back Pain Completed
  37. Phase 2 Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1386 Completed
  38. Phase 2 Study Evaluating Ibuprofen 600 mg Extended Release (ER) For Dental Pain Completed
  39. Phase 2 PF-06372865 In Subjects With Chronic Low Back Pain Completed
  40. Phase 2 Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Participants With Rheumatoid Arthritis Completed
  41. Phase 2 NOLAN: Naproxen or Loratadine and Neulasta Completed
  42. Phase 1 A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED) Completed
  43. Phase 1 Naproxen Sodium/ASA Platelet Study Completed
  44. Phase 1 Inflammation and Daily Life Study Completed

Showing the 50 most-cited and recently-updated of 53 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
TNF inhibitors may be effective for juvenile idiopathic arthritis in patients with DiGeorge syndrome
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TNF inhibitors may be effective for juvenile idiopathic arthritis in patients with DiGeorge syndrome Biologic treatments show promise for children with DiGeorge syndrome
This case report and literature review examines the management of juvenile idiopathic arthritis (JIA) in children with DiGeorge syndrome (DG…
Children with both DiGeorge syndrome and juvenile idiopathic arthritis may find relief from joint pain using specific biologic medications.
Frontiers Jul 30, 2026