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Home › Medications › oxytocin

oxytocin

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of oxytocin

63 trials tracked of oxytocin: 17 in phase 3 or 4 and 5 with published results. The most-cited published study has 140 citations.

63Trials tracked
17Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 14 Phase 3 3 Phase 2 27 Phase 1 4 Other / NA 15
  1. Phase 4 Foley With Oxytocin Versus Foley no Oxytocin for Induction of Labor Completed · 140 cited
  2. Phase 4 Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation Completed · 27 cited
  3. Phase 4 Carbetocin Myocardium Trial 2014 Part 2 Completed · 7 cited
  4. Phase 4 Oxytocin Dosage to Decrease Induction Duration Completed · 7 cited
  5. Phase 4 PK Sampling After IV Oxytocin and Effects on Sensory Function in Healthy Volunteers Completed · 4 cited
  6. Phase 4 Intranasal Oxytocin and Social Cognition, Implicit Preferences and Craving in Alcohol Drinkers Completed
Show 44 more trials
  1. Phase 4 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed
  2. Phase 4 Effects of Intranasal Oxytocin on Satiety Signaling in People With Schizophrenia Completed
  3. Phase 4 Effects of Intramuscular Oxytocin on Sensory Function in Healthy Volunteers With Ultraviolet Burn Injury to the Skin Completed
  4. Phase 4 Effects of Intranasal Oxytocin on Cigarette Smoking Completed
  5. Phase 4 Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV) Completed
  6. Phase 4 Pitocin or Oral Misoprostol for PROM IOL Completed
  7. Phase 4 A Trial of Oral Misoprostol for Labor Augmentation Completed
  8. Phase 4 Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT Completed
  9. Phase 3 Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study Completed
  10. Phase 3 Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section Completed
  11. Phase 3 Study of the Effectiveness of Cervical Ripening Balloon With and Without Oxytocin Completed
  12. Phase 2 A Study of Oxytocin in Children and Adolescents With Autistic Disorder Completed
  13. Phase 2 Oxytocin and Social Cognition in Schizophrenia Completed
  14. Phase 2 Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia Completed
  15. Phase 2 Oxytocin Administration in BDD and OCD Completed
  16. Phase 2 Prolonged Exposure and Oxytocin Completed
  17. Phase 2 Oxytocin, Alcohol Craving, and Intimate Partner Aggression Completed
  18. Phase 2 Neural Substrates of Emotion: Impact of Cocaine Dependence Completed
  19. Phase 2 Sex/Gender Differences in Risk and Resilience to PTSD; Implication of Oxytocin Completed
  20. Phase 2 Deciphering the Role of Oxytocin in Motivation: an fMRI Study Completed
  21. Phase 2 Oxytocin and Affect Processing in Posttraumatic Stress Disorder Completed
  22. Phase 2 Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin Completed
  23. Phase 2 Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals Completed
  24. Phase 2 Preventing Postpartum Depression With Intranasal Oxytocin Completed
  25. Phase 2 Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants Completed
  26. Phase 2 Oxytocin and Social Cognitive Skills Groups Completed
  27. Phase 2 Oxytocin to Treat PTSD Completed
  28. Phase 2 Intranasal Oxytocin in the Treatment of Autism Completed
  29. Phase 2 Effect of Oxytocin Nasal Sprays on Social Behavior in Social Anxiety Disorder Completed
  30. Phase 2 Oxytocin as Adjunctive Treatment of Schizophrenia Completed
  31. Phase 2 Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress Completed
  32. Phase 2 Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders Completed
  33. Phase 2 Oxytocin and Stress Response in Alcohol Use Disorder Completed
  34. Phase 2 Effects of Oxytocin Nasal Spray on Social Affiliation Completed
  35. Phase 2 Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT) Completed
  36. Phase 2 Piloting Treatment With Intranasal Oxytocin in Phelan-McDermid Syndrome Completed
  37. Phase 2 Intranasal Oxytocin for Infants With Prader-Willi Syndrome Completed
  38. Phase 2 Oxytocin for Couples Conflict Resolution Completed
  39. Phase 1 Intranasal Oxytocin Administration and the Neural Correlates of Social and Non-Social Visual Perception Completed
  40. Phase 1 Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress Completed
  41. Phase 1 Oxytocin Effects on Cardiac Electrophysiology Completed
  42. Phase 1 Oxytocin on HR in Sleep Apnea Patient Completed
  43. N/A Cervical Ripening for Induction of Labor: Misoprostol Versus Oxytocin in Conjunction With Foley Balloon Completed
  44. N/A Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia? Completed

Showing the 50 most-cited and recently-updated of 63 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Oxytocin use and high newborn weight are associated with increased episiotomy risk during vaginal birth
Pediatrics Meta-analysis
Oxytocin use and high newborn weight are associated with increased episiotomy risk during vaginal birth Oxytocin use and newborn weight linked to higher episiotomy risk
This meta-analysis of 17,502 individuals undergoing vaginal birth identifies oxytocin use and newborn weight as significant risk factors for…
New data shows that oxytocin use and heavier newborn weights are linked to a higher risk of an episiotomy during vaginal birth.
NEJM Jul 17, 2026
Oxytocin modulates amygdala activity differently in men and women during emotional stress
Psychiatry Meta-analysis
Oxytocin modulates amygdala activity differently in men and women during emotional stress Oxytocin affects the brain's anxiety center differently in men and women
This meta-analysis of neuroimaging studies involving 3337 participants found that oxytocin modulates amygdala activity in response to emotio…
A large review of brain scans shows that oxytocin impacts the amygdala, a key area for fear, in different ways depending on a person's gende…
Jul 1, 2026
HIFU combined with ethanol ablation or GnRH-a improves intraoperative outcomes for adenomyosis treatment
Drug Pipeline Meta-analysis
HIFU combined with ethanol ablation or GnRH-a improves intraoperative outcomes for adenomyosis treatment HIFU Combined With Medication Shows Better Results for Adenomyosis
This network meta-analysis of 1,685 patients evaluated HIFU combined with various medications compared to HIFU alone for adenomyosis. The an…
Combining high-intensity focused ultrasound (HIFU) with specific medications may improve treatment outcomes for people with adenomyosis.
Frontiers Jun 13, 2026
Tranexamic acid reduces postpartum haemorrhage in placenta praevia caesarean delivery
Drug Pipeline RCT
Tranexamic acid reduces postpartum haemorrhage in placenta praevia caesarean delivery New Drug Cuts Heavy Bleeding Risk After C Section Births
This phase 3 randomized controlled trial in 1732 women with placenta praevia undergoing caesarean delivery found that prophylactic tranexami…
A common drug given during C sections cuts heavy bleeding risk for women with placenta praevia, a dangerous pregnancy condition affecting th…
May 14, 2026
Narrative review suggests oxytocin signaling modulates sleep, stress, and social interaction in humans and animals
Neurology Sys. Review
Narrative review suggests oxytocin signaling modulates sleep, stress, and social interaction in humans and animals Sleep, Stress, and a New Social Fix
This narrative review examines oxytocin (OT) signaling in human and animal studies regarding sleep regulation, stress physiology, and social…
Oxytocin from positive social contact may help stabilize sleep and lower stress, breaking the vicious cycle that traps many adults.
Frontiers Apr 21, 2026