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Home › Conditions › Sleep Disorders, Intrinsic

Sleep Disorders, Intrinsic

Subtypes of Sleep Disorders, Intrinsic

Obstructive Sleep Apnea 28 Insomnia 27 Restless Legs Syndrome 6 Sleep-disordered breathing 3 Narcolepsy 2 Sleep apnea 2 Idiopathic Hypersomnia 1 Central sleep apnea 0

80 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sleep Disorders, Intrinsic

52 trials tracked for Sleep Disorders, Intrinsic: 19 in phase 3 or 4 and 4 with published results. The most-cited published study has 306 citations.

52Trials tracked
19Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 9 Phase 3 10 Phase 2 6 Phase 1 1 Other / NA 26
  1. Phase 3 Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities Completed · 306 cited
  2. Phase 3 The Healthy Patterns Sleep Study Completed · 70 cited
  3. Phase 3 Brain Function in Premenopausal Women Receiving Tamoxifen With or Without Ovarian Function Suppression for Early-Stage Breast Cancer on Clinical Trial IBCSG 24-02 Completed · 39 cited
  4. Phase 4 Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia Completed · 4 cited
  5. Phase 4 Characteristics of Sleep Patterns in Young Adults With and Without Insomnia Completed
  6. Phase 4 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed
Show 44 more trials
  1. Phase 4 Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Completed
  2. Phase 4 Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes Completed
  3. Phase 4 The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726) Completed
  4. Phase 4 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed
  5. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  6. Phase 4 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed
  7. Phase 3 Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709) Completed
  8. Phase 3 Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer Completed
  9. Phase 3 A Long-Term Safety Study of Org 50081 (Esmirtazapine) in Elderly Outpatients With Chronic Primary Insomnia (176005/P05697/MK-8265-001) Completed
  10. Phase 3 Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD Completed
  11. Phase 3 Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia Completed
  12. Phase 3 A 6-Month Efficacy and Safety Study of Org 50081 in Adult Patients With Chronic Primary Insomnia (21106/P05701/MK-8265-002) Completed
  13. Phase 3 The Effectiveness of Regular Exercise on Improving Sleep in Older Adults Completed
  14. Phase 2 Melatonin Supplements for Improving Sleep in Individuals With Hypertension Completed
  15. Phase 2 Yoga in Treating Sleep Disturbance in Cancer Survivors Completed
  16. Phase 2 Exploratory Subjective Sleep Study of a Prototype Nasal Dilator Completed
  17. Phase 2 Study of Sleep-maintenance Activity of 3 Doses of SKP-1041 Completed
  18. Phase 2 Study of Donepezil in Female Breast Cancer Survivors With Cognitive Dysfunction Completed
  19. Phase 2 Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor Completed
  20. Phase 1 Light for Renal Transplant Recipients Having a Sleep-Wake Dysregulation Completed
  21. N/A Randomized, Controlled, Double Blind Trial of Eszopiclone for Insomnia Associated With Schizophrenia Completed
  22. N/A Non-Pharmacological Interventions on Sleep in Post-Acute Rehabilitation Completed
  23. N/A TatchSleep as a Tool to Aid in Sleep Apnea Analysis Completed
  24. N/A Zolpidem CR and Hospitalized Patients With Dementia Completed
  25. N/A WatchPAT Device Validation Study Compared to Polysomnography Completed
  26. N/A The Effect of Therapeutic Touch on Sleep and Anxiety Completed
  27. N/A Insomnia Self-Management in Heart Failure Completed
  28. N/A Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders Completed
  29. N/A Sleep Length and Circadian Regulation in Humans Completed
  30. N/A Implementing and Sustaining a Sleep Treatment to Improve Community Mental Part 1: Implementation Health Outcomes Completed
  31. N/A Sleep Specialty Consultation: Improving Management of Sleep Disorders Completed
  32. N/A Three Different Programs of Paced Breathing in Treating Hot Flashes in Women Completed
  33. N/A Brief Behavioral Therapy in Improving Sleep Disorders in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy Completed
  34. N/A Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer Completed
  35. N/A Remote Guided Caffeine Reduction Completed
  36. N/A Enhancing Sleep Quality for Nursing Home Residents With Dementia Completed
  37. N/A EEG Biofeedback Therapy as an Adjunct Treatment for PTSD Completed
  38. N/A PASCONAL NERVENTROPFEN in the Treatment of Nervous Diseases Completed
  39. N/A Glutathione and Health With Post-Polio Syndrome Completed
  40. N/A Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 2: Train-the-Trainer Completed
  41. N/A Light Therapy for PD - Dose Selection Completed
  42. N/A Yoga or Educational Wellness Class for Women With Stage I, Stage II, or Stage III Breast Cancer Undergoing Chemotherapy Completed
  43. N/A Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) Completed
  44. N/A Efficacy of a Brief Nightmare Treatment for Veterans Completed

Showing the 50 most-cited and recently-updated of 52 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep Disorders, Intrinsic: what the trials found

Pharmacological interventions demonstrate varied efficacy in managing sleep parameters. Eszopiclone 7 and Zolpidem 8 are established treatments. Specifically, Eszopiclone has been utilized in clinical settings 7, while Zolpidem is an established intervention for sleep disorders 8.

Esmirtazapine shows significant improvements in several sleep metrics; it significantly increased Total Sleep Time (TST) 18, reduced Wake Time After Sleep Onset (WASO) 18, and improved Alertness at Awakening, Feeling Full of Energy, and Ability to Work/Function 19. Polysomnography measurements with Eszopiclone showed significant improvements in WASO 17 and Latency to Persistent Sleep 17, alongside changes in Total Sleep Time 17.

Other pharmacological agents show specific effects: Pregabalin significantly reduced Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) 22. Circadin showed significant improvements in Total Sleep Time 13 and Sleep Latency 13. Milnacipran showed a statistically significant improvement in Sleep Efficiency (SE) 9, though it did not significantly impact the Number of Awakenings After Sleep Onset (NAASO) 9 or Wake After Sleep Onset (WASO) 9.

Non-pharmacological and other interventions include armodafinil, which showed a significant improvement in Clinical Global Impression of Change (CGI-C) 11 and the Epworth Sleepiness Scale (ESS) 11, though it did not significantly change Maintenance of Wakefulness Test (MWT) scores 11. Stribild was associated with improvements in Sleep Disorder Scores 6.

Other interventions, such as Mometasone furoate nasal spray 12 and Tamoxifen 15, did not show statistically significant changes in primary sleep metrics like Apnea-Hypopnea Index or cognitive function respectively.

Recent results — preliminary, needs further review

  • Therapeutic touch was associated with improved Visual Analogue Scale scores (p=0.001) and improved Sleep Duration and Sleep Onset Difficulties (p=0.040) 2.
  • Exercise intervention is currently being studied as a potential treatment 1.
  • SunRay Light Boxes are under investigation for sleep disorders 3.

For the clinician treating this condition

  • Esmirtazapine provides significant improvements in TST, WASO, and subjective measures of alertness and functionality [17, 18, 19].
  • Pregabalin is effective for reducing Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) 22.
  • Circadin significantly improves both Total Sleep Time and Sleep Latency 13.
  • Armodafinil shows significant improvements in subjective sleepiness (ESS) and overall clinical impression of change 11.

AI synthesis of 15 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
CBT-I doubles absolute insomnia remission compared with sleep hygiene across 77 randomized controlled trials
Psychiatry Meta-analysis
CBT-I doubles absolute insomnia remission compared with sleep hygiene across 77 randomized controlled trials CBT-I Doubles Insomnia Remission Compared to Sleep Hygiene
This systematic review and network meta-analysis of 5,731 participants found that CBT-I, SRT+SCT, SRT, and SCT were associated with higher r…
Behavioral therapy for insomnia doubles remission rates, and simpler versions may work too.
medRxiv Jul 9, 2026
Refugee and asylum seeker status is associated with high prevalence of clinically significant sleep disturbances
Pediatrics Meta-analysis
Refugee and asylum seeker status is associated with high prevalence of clinically significant sleep disturbances Refugees face high rates of insomnia and poor sleep
This meta-analysis of 66 studies involving 42,956 participants indicates that refugees and asylum seekers experience significant insomnia se…
Nearly half of refugees experience serious sleep problems, a new analysis finds, with insomnia scores bordering on moderate clinical insomni…
Jul 3, 2026
Immune-mediated loss of HCRT neurons drives sleep-wake circuit instability and brain network reconfiguration in narcolepsy
Allergy & Immunology Sys. Review
Immune-mediated loss of HCRT neurons drives sleep-wake circuit instability and brain network reconfiguration in narcolepsy New research explains how immune attacks cause narcolepsy symptoms
This systematic review synthesizes the pathophysiology of narcolepsy, focusing on how genetic and environmental factors trigger an immune-me…
A new look at narcolepsy reveals how an immune-driven attack on specific brain cells causes sleep issues and sudden muscle weakness.
Frontiers Jun 23, 2026
Exercise combined with CBT is the most consistently supported intervention for improving insomnia sleep quality
ENT (Otolaryngology) Meta-analysis
Exercise combined with CBT is the most consistently supported intervention for improving insomnia sleep quality Exercise combined with therapy shows promise for treating insomnia
This systematic review and network meta-analysis of 31 RCTs involving 2,457 participants found that exercise combined with cognitive behavio…
Combining exercise with cognitive behavioral therapy may improve sleep quality and help people fall asleep faster when dealing with chronic …
Frontiers Jun 20, 2026
Mind-body therapies significantly improve sleep quality in perinatal women with a mean difference of -2.63
Primary Care & Family Medicine Meta-analysis
Mind-body therapies significantly improve sleep quality in perinatal women with a mean difference of -2.63 Mind-body therapies improve sleep quality for perinatal women
This systematic review and meta-analysis of 13 randomized controlled trials involving 782 participants found that mindfulness, Pilates, and …
Yoga, Pilates, and mindfulness may offer a helpful way for pregnant and new mothers to improve their sleep quality during a demanding time.
Frontiers Jun 19, 2026
Exercise improves sleep questionnaire scores for sedentary adults with insomnia across multiple modalities
Physical Medicine & Rehab Sys. Review
Exercise improves sleep questionnaire scores for sedentary adults with insomnia across multiple modalities Different types of exercise improve sleep for people with insomnia
This network meta-analysis of 31 RCTs involving 1,420 participants indicates that various exercise modalities significantly improve sleep qu…
New data shows that various forms of exercise, from aerobic to mind-body routines, can significantly improve sleep quality for those with in…
Jun 15, 2026
DaVinci Single-Port transoral robotic surgery is feasible across multiple indications including oncology and sleep apnea
Oncology Meta-analysis
DaVinci Single-Port transoral robotic surgery is feasible across multiple indications including oncology and sleep apnea Single-Port Robot Shows Promise for Sleep Apnea Surgery
This systematic review and meta-analysis of 479 patients evaluates the feasibility of DaVinci Single-Port (SP) transoral robotic surgery (TO…
A new analysis finds single-port robotic surgery for sleep apnea is feasible, with short operating times and low blood loss.
Jun 13, 2026
TCM nursing techniques combined with music-based interventions improve sleep quality in older adults
Psychiatry Meta-analysis
TCM nursing techniques combined with music-based interventions improve sleep quality in older adults Chinese Medicine and Music Improve Sleep in Older Adults
This systematic review and meta-analysis of 838 participants found that traditional Chinese medicine (TCM) nursing techniques combined with …
A review of 838 older adults finds that combining traditional Chinese nursing techniques with music boosts sleep and eases anxiety and pain.
Frontiers Jun 11, 2026
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults
Nutrition & Obesity Medicine Meta-analysis
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults Pre-existing health conditions may slightly reduce weight loss after surgery
A meta-analysis of twenty-three studies reveals that mental illness, diabetes, and sleep apnea are associated with slightly lower weight los…
Adults with mental illness or diabetes before surgery saw slightly less weight loss. Other conditions like high blood pressure did not affec…
Jun 6, 2026
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds
Pulmonology & Critical Care Meta-analysis
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds 1 in 7 COPD patients decline or stop breathing therapy
This systematic review and meta-analysis of patients with COPD newly prescribed long-term noninvasive positive airway pressure (PAP) therapy…
A new analysis finds 14% of COPD patients decline or stop long-term breathing therapy, often within six weeks.
Jun 4, 2026
NIV with total face mask managed acute respiratory failure in two patients with Madelung's disease and COVID-19 pneumonia
Rheumatology Sys. Review
NIV with total face mask managed acute respiratory failure in two patients with Madelung's disease and COVID-19 pneumonia Non-invasive ventilation may help patients with Madelung's disease and respiratory failure
This case series describes non-invasive ventilation using a total face mask in two patients with Madelung's disease who experienced acute re…
A small case series suggests non-invasive ventilation can manage acute respiratory failure in patients with Madelung's disease, though more …
Frontiers Jun 4, 2026
Team sports may improve sleep quality but evidence is inconsistent and limited
Psychiatry Meta-analysis
Team sports may improve sleep quality but evidence is inconsistent and limited Team sports may improve sleep quality in young people
This systematic review of 809 participants across diverse populations found that team sports such as football and basketball may improve sle…
A review of studies suggests team sports like football and volleyball could help improve sleep for adolescents, students, and athletes, but …
Frontiers Jun 3, 2026

Questions about Sleep Disorders, Intrinsic

How do sleep disorders impact gait quality and fall risk in older adults?

Sleep disorders in older adults are linked to worse balance control and a higher chance of falling, even if walking speed does not change.

Full answer →
Are sleep problems linked to a higher risk of falling in older adults?

Yes, sleep problems are linked to a higher risk of falling in older adults, likely due to impaired gait quality and balance.

Full answer →
Can cannabis use affect my sleep disorders based on genetic studies?

Genetic studies show that cannabis use and sleep disorders share specific genetic risks, particularly for insomnia and nighttime activity levels.

Full answer →

All Sleep Disorders, Intrinsic Articles