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Home › Medications › sildenafil

sildenafil

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of sildenafil

53 trials tracked of sildenafil: 24 in phase 3 or 4 and 5 with published results. The most-cited published study has 317 citations.

53Trials tracked
24Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 13 Phase 3 11 Phase 2 19 Phase 1 3 Other / NA 7
  1. Phase 3 Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PH Completed · 317 cited
  2. Phase 3 Efficacy and Safety of Nintedanib Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function Impairment Completed · 259 cited
  3. Phase 4 Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy Completed · 160 cited
  4. Phase 4 Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis Completed · 73 cited
  5. Phase 3 Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis Completed · 6 cited
  6. Phase 4 Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension Completed
Show 44 more trials
  1. Phase 4 Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle. Completed
  2. Phase 4 The Effects of Sildenafil on Exercise Function and Capacity in Patients With Fontan Circulation Completed
  3. Phase 4 A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China Completed
  4. Phase 4 A Multicenter, Open Label, To Evaluate The Efficacy And Satisfaction Of Patrex® In Men With Erectile Dysfunction. Completed
  5. Phase 4 Combination Therapy in Pulmonary Arterial Hypertension Completed
  6. Phase 4 Effects of Viagra on Heart Function in Patients With Heart Failure Completed
  7. Phase 4 A Study in Patients With Erectile Dysfunction Completed
  8. Phase 4 Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial Hypertension Completed
  9. Phase 4 Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1) Completed
  10. Phase 4 Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes Completed
  11. Phase 3 Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Participants Completed
  12. Phase 3 Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) Study Completed
  13. Phase 3 The Efficacy and Safety of Sildenafil Citrate Used in Combination With Intravenous Epoprostenol in PAH Completed
  14. Phase 3 A Long Term Extension Study Evaluating Safety Of Sildenafil Citrate When Used To Treat Pulmonary Arterial Hypertension (PAH) In Children Completed
  15. Phase 3 Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary Fibrosis Completed
  16. Phase 3 A Randomized, Double-Blind, Placebo-Controlled Study of Sildenafil in Children With Pulmonary Arterial Hypertension. Completed
  17. Phase 3 Evaluating the Effectiveness of Sildenafil at Improving Health Outcomes and Exercise Ability in People With Diastolic Heart Failure (The RELAX Study) Completed
  18. Phase 3 Sildenafil to Improve Exercise Capacity in People With Thalassemia and Pulmonary Hypertension Completed
  19. Phase 2 Sildenafil After the Fontan Operation Completed
  20. Phase 2 Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Intermediate or High Probability of Group 3 Pulmonary Hypertension Completed
  21. Phase 2 Evaluation of Drug-drug Interaction Between LCZ696 and Sildenafil in Subjects With Mild to Moderate Hypertension Completed
  22. Phase 2 Safety of Sildenafil in Premature Infants Completed
  23. Phase 2 Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) Prevention Completed
  24. Phase 2 A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations Completed
  25. Phase 2 Evaluation of the Pharmacodynamic Effect of the Combination of Sildenafil and Riociguat on Blood Pressure and Other Safety Parameters. Completed
  26. Phase 2 Viagra in the Treatment of Primary Dysmenorrhea Completed
  27. Phase 2 Sildenafil for Chronic Obstructive Pulmonary Disease Completed
  28. Phase 2 Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe CF Completed
  29. Phase 2 Sildenafil Study to Treat Idiopathic Pulmonary Fibrosis Completed
  30. Phase 2 Effects of Sildenafil on CFTR-dependent Ion Transport Activity Completed
  31. Phase 2 Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma Completed
  32. Phase 2 Safety and Efficacy of Sildenafil in Cystic Fibrosis (CF) Lung Disease Completed
  33. Phase 2 Sildenafil for Treatment of Choroidal Ischemia Completed
  34. Phase 2 Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia Completed
  35. Phase 2 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed
  36. Phase 2 Study of Sildenafil Citrate on Insulin Resistance in African American Completed
  37. Phase 2 Improving Right Ventricular Function in Young Adults Born Preterm Completed
  38. Phase 1 Pharmacokinetics Of Sildenafil Orally Disintegrating Tablet Formulation Given With Or Without Food. Completed
  39. Phase 1 Sildenafil To Prevent Clot Completed
  40. Phase 1 Clinical Pharmacology Study of Oral Edaravone in Healthy Adult Males (Drug Interaction Study and Preliminary Regimen-Finding Study) Completed
  41. N/A To Provide Sildenafil Therapy To Eligible Adult Patients With Pulmonary Arterial Hypertension For 112 Weeks Completed
  42. N/A Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability Completed
  43. N/A Phosphodiesterase Type 5 Inhibition to Improve Endothelial Function and Vascular Remodeling in Chronic Kidney Disease and End Stage Renal Disease Patients Requiring New Arteriovenous Fistula Completed
  44. N/A Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus Completed

Showing the 50 most-cited and recently-updated of 53 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility
Diabetes & Endocrinology Meta-analysis
Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility New findings show specific treatments may improve fertility outcomes
This meta-analysis evaluates various interventions for infertility, including hormonal therapies, ART strategies, and investigational adjunc…
Certain supplements and stress management programs show promise for women struggling with infertility, though more data is needed on safety.
Frontiers Jun 9, 2026
PDE5 inhibitors increased cerebral blood flow in white matter hyperintensity regions in adults with cerebral small vessel disease
Neurology Meta-analysis
PDE5 inhibitors increased cerebral blood flow in white matter hyperintensity regions in adults with cerebral small vessel disease An Old Drug Class May Protect the Brain From Silent Damage
This systematic review and meta-analysis evaluated phosphodiesterase-5 inhibitors (sildenafil or tadalafil) versus placebo in 236 adults wit…
Drugs already approved for other conditions may help restore blood flow in a part of the brain that quietly fuels strokes and dementia.
Frontiers Apr 14, 2026