Narrative review discusses cerebral small vessel disease without reporting specific interventions or outcomes
Narrative review offers perspective on cerebral small vessel disease
This narrative review addresses cerebral small vessel disease but does not report specific interventions, comparators, or outcomes. The auth…
A narrative review discusses cerebral small vessel disease without reporting new clinical data or specific treatment outcomes.
Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients
High small-vessel disease scores raise stroke risk in hemorrhage-prone patients
This post hoc analysis of a prospective, multicenter randomized controlled trial in 1,454 hemorrhage-prone patients found that higher modifi…
Patients with high small-vessel disease scores face higher risks of ischemic stroke and heart events, even if they have a history of bleedin…
Inflammatory cytokines correlate with vestibular-oculomotor dysfunction in Fabry disease patients
Could a blood marker signal eye movement trouble in Fabry disease?
This prospective observational cohort study of 40 Fabry disease patients found significant correlations between specific inflammatory cytoki…
Higher blood inflammation markers in Fabry disease patients are linked to specific eye movement problems like slower eye jumps and less accu…
Genetic analyses suggest causal links between type 2 diabetes markers and cerebral small vessel disease phenotypes
High Blood Sugar May Drive Small Stroke Risk
This review synthesizes genome-wide association and Mendelian randomization data linking type 2 diabetes and glycemic indicators to cerebral…
Managing blood sugar after meals might lower your risk of a specific type of stroke.
TTI-0102 Improves Fatigue Scores in MELAS Syndrome Patients During Randomized Phase 2 Trial
New Drug Reduces Fatigue in Rare Mitochondrial Disease
This randomized, single-blind, placebo-controlled Phase 2 trial enrolled 9 patients with MELAS syndrome caused by mtDNA m.3243A>G mutation.
This new medicine could finally give tired patients a sustainable boost in energy without the painful stomach issues that stop people from t…
PDE5 inhibitors increased cerebral blood flow in white matter hyperintensity regions in adults with cerebral small vessel disease
An Old Drug Class May Protect the Brain From Silent Damage
This systematic review and meta-analysis evaluated phosphodiesterase-5 inhibitors (sildenafil or tadalafil) versus placebo in 236 adults wit…
Drugs already approved for other conditions may help restore blood flow in a part of the brain that quietly fuels strokes and dementia.
Parkinson disease associated with higher cerebral small vessel disease burden compared to healthy controls in this meta-analysis
Parkinson's May Be a Blood Vessel Problem Too, New Review Hints
This systematic review and meta-analysis of cross-sectional studies compared adults with idiopathic Parkinson disease to healthy controls.
Parkinson's may be partly a disease of the brain's plumbing, not just its dopamine wiring — and that could reshape how doctors think about g…
Proteomic age acceleration linked to cerebral small vessel disease markers in US cohorts
Blood protein markers of aging linked to brain vessel disease in US community studies
An observational cohort study of US community-based participants found that higher proteomic age acceleration was associated with increased …
Higher blood protein markers of aging are linked to greater brain vessel disease and more white matter damage in US community studies.
Questions about Cerebral small vessel disease
Can genetic markers for diabetes predict my cerebral small vessel disease risk?
Yes, genetic markers for diabetes are linked to cerebral small vessel disease risk, but they are not a standalone predictor; other factors like blood pressure also matter.
Full answer →Do people with Parkinson disease have more severe cerebral small vessel disease?
Yes, people with Parkinson disease tend to have a higher burden of cerebral small vessel disease than healthy controls, which may worsen motor and cognitive symptoms.
Full answer →Is my brain aging faster if I have high proteomic age acceleration?
Yes, research shows that higher proteomic age acceleration is linked to greater brain damage markers found in cerebral small vessel disease.
Full answer →Can taking sildenafil improve blood flow in my brain white matter?
Yes, a 2025 meta-analysis found that sildenafil significantly increased blood flow in the white matter regions affected by cerebral small vessel disease.
Full answer →