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Home › Medications › trazodone

trazodone

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of trazodone

12 trials tracked of trazodone: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 24 citations.

12Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 2 1 Phase 1 4 Other / NA 4
  1. Phase 3 Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis Completed · 24 cited
  2. Phase 4 CBT-I or Zolpidem/Trazodone for Insomnia Completed
  3. Phase 3 Insomnia and Drug Relapse Risk Completed
  4. Phase 2 Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI Completed
  5. Phase 1 Comparative Bioavailability Study of Extended-release and Immediate-release Trazodone in Healthy Adult Volunteers Completed
  6. Phase 1 A Study to Compare the Bioavailability of 300 mg Trazodone Hydrochloride Extended-release Caplets and 100 mg Trazodone Hydrochloride Immediate-release Tablets at Steady State Completed
Show 6 more trials
  1. Phase 1 Comparative Bioavailability Study of Two Prototypes of Trazodone Controlled-release Products and Two Marketed Reference Products in Healthy Volunteers Completed
  2. Phase 1 A Study to Compare the Bioavailability of 300 mg Trazodone Hydrochloride Extended-release Caplets and 100 mg Trazodone Hydrochloride Immediate-release Tablets (Administered Three Times Daily) Completed
  3. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Completed
  4. N/A Study of Trazodone & Cognitive Behavioral Therapy to Treat Insomnia Completed
  5. N/A The Effects of Trazodone on Sleep Apnea Severity Completed
  6. N/A Sequenced Therapies for Comorbid and Primary Insomnias Completed

Showing the 12 most-cited and recently-updated of 12 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Trazodone improves sleep architecture and duration in patients with depression and sleep disorders
Psychiatry Meta-analysis
Trazodone improves sleep architecture and duration in patients with depression and sleep disorders Trazodone may improve sleep quality for people with depression
This exploratory meta-analysis of 5 RCTs and 3 single-arm studies indicates that trazodone improves total sleep time and sleep efficiency wh…
Trazodone may help people with depression get more sleep and fall asleep faster, though it can cause side effects like dizziness and sleepin…
Frontiers Sep 10, 2026
DORAs show strongest evidence for insomnia while sedating antidepressants vary in antidepressant activity and side effects
Psychiatry Sys. Review
DORAs show strongest evidence for insomnia while sedating antidepressants vary in antidepressant activity and side effects Sedating Antidepressants and DORAs Show Different Benefits for Depression and Insomnia
This narrative review examines sedating antidepressants and dual orexin receptor antagonists (DORAs) for patients with major depressive diso…
New research highlights how different sedating antidepressants and DORAs offer varying levels of support for patients with depression and in…
Frontiers Sep 9, 2026