N/A N=49 Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
Anesthesia
Primary: Participants Anesthetic Preference — 32; 16 participant preference selection
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=35 Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
Endodontic Disease · Post Operative Pain · Symptomatic Irreversible Pulpitis
Primary: Post-operative Pain Level 6 Hours on a Visual Analog Scale — 64.2; 43.1 units on a scale
Phase 4 N=60 Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Anesthetic Effectiveness
Primary: Successful Pulpal Anesthesia. — 37; 27; 22; 33 participants
Phase 3 N=59 The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort
Pain, Procedural
Primary: Post Operative Pain — 13; 10 Participants
Phase 4 N=25 Effectiveness Study of Different Local Anesthetic Mixtures
Pain
Primary: Length of Action — 6.63; 7.02; 7.48; 7.16 minutes — p=0.359
N/A N=76 Local Anesthesia and Pain Perception During an Amniocentesis
Pregnancy
Primary: Intensity of Perceived Maternal Pain as Measured by the Visual Analogue Scale (VAS) — 9.5; 18.4 units on a scale
Phase 4 N=150 Local Anesthetics for Pain Reduction Prior to IV Line Placement
Pain · Local Anesthesia for Peripheral Intravenous Catheterization
Primary: Pain Score Following Anesthetic Administration — 2.81; 1.64; 2.05 units on a scale
Phase 4 N=20 Buffered Local Anesthetic
Dental Pain
Primary: Pain Score as Measured by the Behavior Pain Scale — 2.24; 2.61 score on a scale — p=0.005
Phase 4 N=150 Split Face Study of the Duration of Local Anesthetics
Anesthetics, Local
Primary: Time to Return to Baseline Sensation, as Determined by Binary Outcomes (Yes/no) in 15 Minute Increments — 54.34; 49.86; 43.13; 55.78 Minutes — p=0.93
Phase 4 N=31 Anesthetic Effect Duration Assessment
Healthy Volunteers
Primary: Duration of Anesthesia(Minutes) — 80; 140; 0; 400 Minutes
Phase 4 N=100 The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
Pain
Primary: Number of Participants Achieving Pulpal Anesthesia Success. — 44; 40 Participants — p=1.00
Phase 4 N=64 Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
Anesthesia of Mucous Membrane
Primary: Measurement of Pain Associated With Injection, in Millimeters, According to Visual Analog Scale — 38.5; 26.9 mm
N/A N=154 Effect of Local Anesthetic Dose on Interscalene Block
Shoulder Arthroscopy · Interscalene Block
Primary: Handgrip Strength — 6.45; 2.98 kg
N/A N=24 Clinical Outcomes Maxilla: Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine
Anesthesia
Primary: Mean Time to Pulpal Response After Maxillary Molar Anesthesia — 98.8; 84.5 minutes
Phase 4 N=98 An Evaluation of the Effectiveness of Local Anesthetics Used During Intravenous Catheter Insertion
IV Insertion Pain
Primary: Differences in Patients' Perceptions of Pain Between Treatment Methods — 0.015; 0; 0; 1.909 units on a scale
Early Phase 1 N=70 Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery
Surgical Anesthesia, Cesarean Section
Primary: The Onset Time to Surgical Anesthesia — 558; 655 seconds — p=0.10
N/A N=91 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics
Methemoglobinemia
Primary: Peak Methemoglobin Blood Levels — 3.55; 1.63; 1.60 percentage of methemoglobin in blood — p=<.001
Phase 3 N=75 Comparing Bupivacaine, Lidocaine, and a Combination of Bupivacaine and Lidocaine for Labor Epidural Activation
Labor Pain
Primary: Time to Achieve an Adequate Epidural Level for Labor Analgesia — 7.0; 11.0; 8.5 minutes
Phase 2 N=33 Local Anesthetic Cream in Younger Patients Undergoing Lumbar Punctures
Malignant Neoplasm
Primary: Total Dose of Propofol Administered to Each Patient — 2.94; 3.22 mg/kg — p=0.036
Phase 4 N=40 Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
Symptomatic Irreversible Pulpitis
Primary: VAS Scores as Measures of Profoundness of Pulpal Anesthesia — 3.1; 1.2 Score on a scale
Phase 2 N=40 Experimental Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 Anesthetic Spray in Normal Volunteers
Anesthesia
Primary: Duration of Anesthesia as Measured by Pin Prick Test (PPT) for One Spray CTY-5339-A Compared to One Spray CTY-5339-CB — 17.9; 16.4 minutes — p=0.322
Phase 3 N=646 Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia
Any Ear Nose or Throat Conditions · With Identified Need for a Diagnostic Procedure or Surgery on or Through the Mucous Membranes of the Nasal Cavities
Primary: Immediate and Sustained Anesthetic Success for Cocaine HCl 4% Topical Solution and Placebo Topical Solution — 0.7093; 0.1969 proportion of participants — p=<0.0001
N/A N=23 Clinical Outcomes of Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine
Anesthesia
Primary: Mean Time to Pulpal Response After Mandibular Molar Anesthesia — 99; 98 Minutes — p=0.74
Phase 4 N=201 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
Irreversible Pulpitis
Primary: Anesthetic Success Rate of Supplemental Infiltration Injection — 22; 25; 23; 12 Participants — p=.901
Phase 4 N=50 Lower Third Molar Removal With 2% and 4% Articaine
Impacted Third Molar Tooth · Adverse Reaction to Other Local Anesthetics
Primary: Onset of Anesthetic — 1.5; 1.5 minutes — p=0.192
Phase 4 N=70 Effects of Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair
Post Operative Pain (Post Laparoscopic Hernia Repair)
Primary: Visual Analog Scale Pain Score Assessment (VAS) — 2.96; 3.24 score on a scale
Phase 4 N=26 Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years
Anesthesia, Local · Pain
Primary: Mean Pain Scores Following Injection — 3.0; 3.3 score on a scale — p=0.38
Phase 4 N=103 Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures
Eyelid Tumor · Eyelid Bump · Eyelid Deformity
Primary: Pain on Injection — 2.8; 3.6 score on a scale
Phase 3 N=233 Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2
Diabetes Mellitus · Local Anesthesia
Primary: Duration of Intraoral Local Anesthesia — 132.48; 173.27; 182.09; 195.35 minutes — p=<0.05
Phase 3 N=44 Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face
Anesthesia, Local · Photodamaged Skin · Topical and Infiltration Anesthetic Toxicity
Primary: Self-reported Pain After Laser Treatment — 4.5; 5.0 score on a scale — p=0.102