N/A N=64 Virtual Reality Compared to Screen Based Engagement on Mood
Virtual Reality
Primary: Change in Positive Affect and Negative Affect From Baseline to After a 2 Minute Mood Induction — 3.7; 4.63; 1.97; 1.56 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=94 Stress and the Sympathetic Nervous System in Adults With Depression
Major Depressive Disorder
Primary: Percent of Days Participants Report Stressors — 36; 40 percent of days
N/A N=9 European Deep Brain Stimulation (DBS) Depression Study
Depressive Disorder, Major
Primary: Mean Percent Change From Baseline in MADRS Score — -7.7; -7.4; -8.8; -6.2 percentage change from baseline
N/A N=8 Wake Therapy in the Treatment of Depression
Major Depressive Disorder · Bipolar Disorder
Primary: Structured Interview for the Hamilton Depression Scale With Atypical Depression Supplement(SIGH-ADS) — 16.6 score on a scale
N/A N=205 Depression Attention for Women Now (The DAWN Study)
Depressive Disorder
Primary: Depression Treatment Outcome — 0.96; 1.33 units on a scale
Phase 4 N=16 Identifying and Treating Depression in Hemodialysis Patients
Depression · Hemodialysis-Induced Symptom
Primary: To Determine the Impact of Directly Observed Weekly Fluoxetine Treatment on Remission of Depression Among Hemodialysis Patients. — 6.6 units on a scale
Phase 4 N=40 Depression, Epinephrine, and Platelet Function
Major Depressive Disorder
Primary: Response of Participants, Defined by Change in the 21-item Hamilton Depression Rating Scale (HDRS) From Baseline to Week8 — 5; 9; 2; 4 participants — p=.918
Phase 2 N=902 An Expert System to Reduce Depression in Primary Care
Depression · Depressive Disorder, Major
Primary: Change in Depression Severity — -5.4; -3.7 units on a scale — p=.003
N/A N=1,001 The Effects of Videogames on Depression Symptoms and Brain Dynamics
Major Depressive Disorder
Primary: PHQ-9 Total Change From Baseline to Posttreatment: Experimental Group vs. Treatment as Usual Group — -1.941; -0.803 adjusted score change — p=0.0000022
N/A N=100 Treatment of Depression in Acute Coronary Syndrome (ACS) Patients
Depression
Primary: Depression and Well-being Improvements After Cognitive-Behavioral Therapy and Well-Being Therapy as Assessed by Changes in Clinical Interview for Depression, Compared to…
Phase 4 N=95 Stress and Inflammation in Late-Life Depression
Depression · Inflammation
Primary: IL-6 Levels — 5.25; 18.24; 3.69; 6.84 pg/mL — p=.44
N/A N=26 Transcranial Direct Current Stimulation Therapy for Major Depression
Major Depressive Disorder
Primary: Clinical Response — 22 Participants
N/A N=141 Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients
Pulmonary Disease, Chronic Obstructive · Major Depression
Primary: Composite Antidepressant Score Scale (CAD) — 29; 25; 9; 20 Participants
N/A N=100 Supportive and Supportive-Expressive Treatment for Depression
Major Depressive Disorder
Primary: Hamilton Rating Scale for Depression (HRSD) — 12.32; 12.06; 20.20; 20.08 units on a scale — p=.016
Phase 2 N=27 Effects of Psilocybin in Major Depressive Disorder
Major Depressive Disorder
Primary: The GRID-Hamilton Depression Rating Scale (GRID-HAMD) — 22.9; 22.5; NA; 23.8 units on a scale
N/A N=84 Spirituality Teaching Program for Depressed Adults
Major Depression
Primary: Hamilton Depression Rating Scale - Depression Severity — 20.4; 20.3; 11.9; 18.0 units on a scale
N/A N=80 Coping With Depression in Parkinson's Disease
Parkinson's Disease · Depression
Primary: Hamilton Depression Rating Scale: Baseline — 20.93; 19.38 units on a scale
N/A N=26 Investigating Transcranial Ultrasound as a Potential Intervention for Depression
Depression · Anxiety Disorders
Primary: Depressive Symptoms Assessed With the Beck Depression Inventory-II — -4.42; -.650 units on a scale
Phase 1 N=64 Lipopolysaccharide (LPS) Challenge in Depression
Major Depressive Disorder
Primary: Change in Snaith-Hamilton Pleasure Scale (SHAPS) — 38.4; 33.2; 27.2; 26.2 units on a scale
N/A N=197 Demonstration Study of the Effect of the Transcranial Direct Current Stimulation (tDCS) on Depressed Patients
Depression
Primary: Change From Baseline in Depressive Symptoms on Beck Depression Inventory-II (BDI-II) at Week 13 — 30.27; 29.62; 24.96; 23.98 units on a scale — p=0.862
N/A N=33 Mindfulness Intervention to Study the Neurobiology of Depression
Depression
Primary: Change in Children's Depression Rating Scale - Revised — 27.47; 28.00; 25.53; 31.86 units on a scale
N/A N=99 fMRI Studies of Emotional Brain Circuitry in People With Major Depression
Depression
Primary: Activations in Different Cortical Regions Caused by Emotionally Evocative Task — -0.021; 0.084; 0.021; -0.030 Voxels
Phase 2 N=97 Assessing Symptomatic Clinical Episodes in Depression
Major Depressive Disorder
Primary: MADRS Score - Overall Change From Baseline — 13.7; 8.8 score on a scale — p=<.001
N/A N=21 A Pilot Study of the Immediate Effects of DLPFC tDCS on Attention Bias in Depression
Depression
Primary: Beck Depression Inventory (BDI-II) Score — 21.29 score on a scale
N/A N=201 Depression Outpatient Cardiology Screening Study
Depression · Coronary Heart Disease
Primary: Beck Depression Inventory 2 — 17.4; 15.9 units on a scale
Phase 4 N=21 Brexpiprazole for Bipolar Depression
Bipolar Depression
Primary: The Montgomery-Asberg Depression Rating Scale (MADRS) — 31.95; 9.95; 10.95 score on a scale — p=<.001
Phase 4 N=59 Desvenlafaxine vs. Placebo Treatment of Chronic Depression
Dysthymic Disorder · Dysthymia · Chronic Depressive Disorder
Primary: Hamilton Rating Scale for Depression (HDRS24) — 14.63; 14.21 units on a scale — p=0.09
Phase 3 N=131 Depression in Alzheimer's Disease-2
Alzheimer's Disease · Depression
Primary: Modfied Alzheimer's Disease Cooperative Study- Clinical Global Impression of Change (mADCS-CGIC) — 1; 0; 5; 2 participants — p=0.98
Phase 4 N=65 Duloxetine for Chronic Depression: a Double-blind Study
Dysthymic Disorder · Depressive Disorder NOS
Primary: Hamilton Depression Rating Scale (HDRS) - 24 Total Score — 5; 10 Scores on a scale — p=.003
N/A N=851 Study Comparing Remission Rates, in Patients With Major Depressive Disorder (MDD)
Major Depressive Disorder
Primary: Percentage of Participants With Remission Based on Hamilton Depression Scale (HAM-D) — 54.4 Percentage of participants