Clinical Trial Search

Primary: Change in Pain on the VIsual Analog Scale (VAS) — -.068 change in units on a scale from baseline

Primary: Pain Sensitivity: Pressure Pain Detection Threshold (PPT) — 252.58; 266.17 kPa

Primary: Pain When Walking On A Flat Surface — 0; 1; 8; 4 Participants

Primary: Patient Function (Units on a Scale) — 31 units on a scale

Primary: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months — 27.1; 33.3; 28.9; 26.7 units on a scale

Primary: Change in Knee Extensor Torque — 130.1 Nm

Primary: WOMAC Function — -10.4; -4.8; -4.9; -1.6 Change in Score — p=0.0129

Primary: Change From Baseline in Weekly Mean 24-hour Average Pain Severity (APS) Score From Electronic Diary at 5 Weeks — -2.05; -2.10; -2.09 units on a scale

Primary: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Domain Score at Week 2 — -3.64; -3.15 Units on a scale — p=0.39

Primary: University of California, Los Angeles (UCLA) Activity Score — 5.4 score on a scale

Primary: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) — -4.85; 0.26; -3.97; -2.53 units on a scale — p=0.0003

Primary: Efficacy of Hyaluronic Acid With Sorbitol (SYNOLIS VA) in Overuse Knee Syndrome Assessed With the Knee Injury and Osteoarthritis Outcome Score (KOOS) — 68; 78; 84; 88…

Primary: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Scale — 3.3; 3.0; 2.9 units on scale

Primary: Change in Lower Extremity Function — 10.6; 7.6; -6.4 Change in scores on a scale

Primary: Change From Baseline in WOMAC VA3.1 Pain Subscale Score at Month 6 — -23.6; -14.1 mm — p=0.141

Primary: Self-reported Pain From Baseline to 1, 3, and 6 Months Post-intervention — 50.24; 47.42; 45.42; 43.57 units on a scale — p=0.791

Primary: Change in Medial Knee Contact Forces During Walking — -0.04 bodyweights

Primary: Change Form Baseline in WOMAC A Pain Subscale — -11.14; -11.82 cm — p=<0.025

Primary: Acceptability of Content — 13 Participants

Primary: Cross-sectional Area (CSA) of Muscle Fibers — 2680; 2377; 2028; 1882 micron squared

Primary: Change From Baseline to Week 17 and From Baseline to Week 21 in Pain as Measured by Numerical Rating Scale — -2.1; -1.8; -2.2; -1.5 units on a scale — p=0.495

Primary: Mean WOMAC Scores at Month 6 — 29; 26 units on a scale

Primary: Number of Participants With Viable Specimens for Genetic Analysis — 14 participants

Primary: Osteoarthritis Structural Changes Assessed by Quantitative Magnetic Resonance Imaging With and Without Neuropathic Pain — 14; 7; 5; 1 participants

Primary: Number of Participants Experiencing Treatment-related Adverse Events, as a Measure of Safety — 1; 7; 2 Participants

Primary: Change in KOOS Pain Score — 33 score on a scale — p=0.00041

Primary: Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) — 43.7; 43.7; 36.5; 39.1 units on a scale — p=0.1024

Primary: Change in Cellular Infiltrates From Day 0 to Day 28 — 2; 0; 2; 4 Participants

Primary: Knee Pain Numeric Rating Scale, NRS — 3.15; 5.20 scores on a scale

Primary: Percentage of Participants Who Reported Adequate vs. Inadequate Pain Relief at Baseline — 46.2; 53.8 Percentage of Participants