N/A N=133 Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Traumatic Brain Injury · Suicidality
Primary: Iowa Gambling Test — -4.2; 1.7; 3.5; 5.3 Total Raw on a scale from -100 to 100 — p=>.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=28 Neurobehavioral Intervention as a Novel Treatment Approach for Emotion-Regulatory Deficits
Anxiety · Depression
Primary: Reaction Time to Facial Affect Identification During Emotional Conflict — 802.15; 889.14; 848.79; 937.97 milliseconds — p=0.004
N/A N=35 Neural Bases of Cognitive Rehabilitation for Brain Injury
Brain Injury
Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score
Early Phase 1 N=35 Remediation of Impaired Self-Regulation in Patients With Mild TBI
Mild Traumatic Brain Injury
Primary: Blood Oxygen Level Dependent (BOLD) Brain Signal Measured Using Functional MRI. — 270; 111 voxels — p=<0.0001
Phase 2 N=168 Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury
Neurobehavioral Disinhibition
Primary: Stage 1: Change From Baseline in the Composite of the Clinical Impression Severity Scores on the Neuropsychiatric Inventory Clinician Rating Scale (NPI-C) Subscale of…
N/A N=30 Top-Down Executive Control in Traumatic Brain Injury (TBI), PTSD and Combined
PTSD · TBI (Traumatic Brain Injury)
Primary: Functional Magnetic Resonance Imaging (fMRI) Correlation — .21; .19; .36 r-value
N/A N=62 Neuroimaging Decision Making and Response Inhibition During Smoking Abstinence
Smoking
Primary: Signal Change in Functional Magnetic Resonance Imaging (fMRI) BOLD Signal Between Response Inhibition Trials and Control Trials in Right Inferior Frontal Cortex (rIFC)…
N/A N=91 Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS
Traumatic Brain Injury · Post-Traumatic Stress Disorder
Primary: Change From Baseline in Community Reintegration for Injured Service Members at 2 Months — 40.22; 37.79 score on a scale
N/A N=66 Arbitration Between Habitual and Goal-directed Behavior in Obsessive-compulsive Disorder: Circuit Dynamics and Effects of Noninvasive Neurostimulation
OCD · Decision-Making · tDCS
Primary: Strength of Behaving Model-based (Goal-directed) — 0.09; 0.07; -0.08; 0.06 units on a scale
N/A N=165 Acute Neurobehavioral Program for Improving Functional Status After TBI
Traumatic Brain Injury
Primary: Functional Independence Measure Scores — 88.11; 89.79; 120.57; 119.67 units on a scale
N/A N=9 Behavioral Economics and Communication
Problem Behavior
Primary: Averge of Aappropriate Communication Responses — 3.33 direct observation of 5-min sessions
Phase 4 N=7 Neural Mechanisms of Disulfiram Effects
Alcohol Use Disorder
Primary: Alcohol Use — 0 days
Phase 4 N=81 Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression
Traumatic Brain Injury
Primary: Neuropsychiatric Inventory-Irritability Domain - Observer-rated Proportion Improved ≥ 3 Points Baseline to Day-91 — 30; 31 Participants
N/A N=16 Pilot Study on Training Emerging Adults Skills in Navigating College
Alcohol Abuse · Cognitive Deficit in Attention
Primary: Participant Retention — 85.71; 88.89 percentage of participants
N/A N=160 Neurobehavioral Plasticity to Regular Sugar-Sweetened Beverage Intake: An fMRI Experiment
Obesity · Weight Gain
Primary: Change in Voxel-wise Blood Oxygen Level Dependent (BOLD) Including Outliers Using Functional Magnetic Resonance Imaging (fMRI) of Brain Activation Signals in Response to…
Early Phase 1 N=80 Alcohol, Behavior, and Brain Imaging
Alcohol Drinking · Binge Drinking · Drinking Behavior
Primary: Stop Signal Task (SST) — 255; 215 milliseconds
N/A N=59 Behavioral Treatment of Adolescent Substance Use
Substance Use Disorders
Primary: Any Cannabis Abstinence — 13; 18 participants
Phase 1 N=52 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment · Alzheimer's Disease · Traumatic Brain Injury
Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct
N/A N=31 tDCS for Impulsivity and Compulsivity in Obesity
Impulsivity · Compulsive Overeating · Obesity
Primary: Change in NIH Examiner Flanker Task Reaction Time — -0.03; -0.12 seconds
N/A N=140 Noradrenergic Activity and Attention
Aging
Primary: Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker — 3.8; 4.4; 3.6; 4.5 percentage of first saccades
N/A N=84 The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
Antisocial Behavior · Aggression
Primary: Change in Antisocial Behavior Inclinations at 24 Hours — 1.41; 3.05 score on a scale
N/A N=32 The Effect of Repeated Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
Antisocial Behavior · Aggression
Primary: Number of Pins Inserted Into a Virtual Voodoo Doll After 48 Hours — 3.77; .64 pins
N/A N=50 Valproate for Mood Swings and Alcohol Use Following Head Injury
Traumatic Brain Injury (TBI) · Alcoholism
Primary: Severity of Affective Lability Based on Shortened Agitated Behavior Scale — 9.22; 9.39 units on a scale
N/A N=307 Behavior Enhances Drug Reduction of Incontinence (BE-DRI)
Urinary Incontinence (UI)
Primary: Proportion of Women Who Meet Definition of Success — 43; 41 participants — p=0.74
N/A N=40 Relationship Between Attention and Emotional Regulation Post-Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Baseline Measures Before Treatment
N/A N=84 Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking
Alcohol Drinking · Alcohol Intoxication · Alcoholism
Primary: Drinks Per Drinking Day — 5.12; 5.64; 4.95; 5.48 drinks per drinking day
N/A N=16 Enhancement of Behavioral and Cognitive Outcomes in Autism Spectrum Disorder Via Neurostimulation
Autism Spectrum Disorder
Primary: The Effects of rTMS on Reciprocal Social Awareness — 68; 79.667; 64.2; 74 total raw score (higher=worse)
Phase 2 N=16 Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia
Frontotemporal Dementia (FTD)
Primary: Change in Agitation and Aggression as Measured by the Neuropsychiatric Inventory Scale (NPI) — 7.14; 5.75 score on a scale
N/A N=10 Response Inhibition in Tourette Syndrome
Tourette Syndrome
Primary: Stop Signal Reaction Time (SSRT) — 249; 245 milliseconds — p=0.49
Early Phase 1 N=8 Neurobehavioral Mechanisms of Cocaine Choice
Cocaine Use Disorder
Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 110; 98; 90 number of choices