Phase 4 N=99 Propofol in Emergence Agitation
Emergence Agitation
Primary: Number of Participants With Emergent Agitation — 16; 24 Participants
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Phase 4 N=116 Preventing Propofol Injection Pain: Prospective Randomized Trial Comparing Propofol Versus Fospropofol
Complication of Injection · Pain
Primary: Compare Incidence and Intensity of Pain on Injection That is Caused by Propofol (Lipid Emulsion) Versus the Test Drug Fospropofol.
N/A N=51 Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs
Hypotension · Anesthesia
Primary: Number of Participants Who Had Hypotensive Events — 8; 21 Participants — p=0.01
N/A N=40 Desflurane Versus Propofol in the Sitting Position
Cerebral Ischemia
Primary: Regional Cerebral Oxygen Satuation (rSO2) — 77.4; 72.5; 76; 70 percentage of rSO2 (%)
N/A N=85 A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters
Blood Pressure
Primary: Percent of Subjects With a Greater Than 20% Decrease in Systolic Blood Pressure (SBP) Following Induction of General Anesthesia — 48; 12; 67; 39 Percentage of subjects…
Phase 4 N=75 Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia
Surgery
Primary: Blood Pressure — 105; 122; 117.88 mmHg
N/A N=60 Conscious Sedation for Epilepsy Surgery
Epilepsy
Primary: Patients Satisfaction — 6.33; 6.45 score on a scale
Phase 3 N=100 Analyzing the Relationship Between Speed Propofol is Given and Low Blood Pressure
Hypotension on Induction
Primary: Patients Administered Propofol at a Slower Rate of Infusion Will Have Lower Incidence of Post Induction Hypotension Than Patients Administered Propofol at FDA Approved…
Phase 3 N=100 Use of a Modified Propofol Emulsion in Adults
Anesthesia
Primary: Incidence of Expression of Pain During Injection — 1; 7 participants
Phase 4 N=77 Dexmedetomidine Versus Propofol in Vitreoretinal Surgery
Retinal Detachment
Primary: Adequate Sedation Via Bispectral Index Score (BIS)and University of Michigan Sedation Scale (UMSS) — 84.8; 88; .90; .94 units on a scale — p=0.04
Phase 4 N=192 Impact of Propofol Reduction in Anesthesia Induction
Propofol Adverse Reaction · Anesthesia
Primary: Systolic Blood Pressure Variation — 26; 23; 18; 22 percentage of variation
N/A N=102 Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy
Conscious Sedation Failure During Procedure
Primary: Change in Transcutaneous CO2 Pressure — 43.6; 45.6 Unit of Measure "mmHg" — p=0.281
Phase 4 N=156 Preventing Propofol-associated Injection Pain
Pain
Primary: Verbal Pain Score — 3; 0; 0 Units on a scale — p=<0.0001
N/A N=60 Propofol Pharmacokinetics and Pharmacodynamics Modelling
Intravenous Anesthetic Agent Overdose
Primary: Plasma Propofol Concentration (mcg/mL) — 2.36; 3.12; 2.91 mcg/mL
N/A N=36 EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia
Brain Activity Under Sedation
Primary: EEG Power in Alpha, Slow, and Delta Bands — 10; 0.55; 2.5 Power of alpha band (decibels)
Phase 4 N=107 Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
Pain
Primary: Patients With Clinical Signs of Respiratory Depression or Sub Clinical Respiratory Depressions Measured by Capnography and Pulse Oximetry. — 22; 21 Participants
Phase 3 N=160 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial
Critical Illness
Primary: Mean Arterial Pressure — 82.8; 80.9; 81.7; 77.6 mm Hg — p=0.385
Phase 2 N=8 Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion
Brain Injury · Intracranial Pressure
Primary: Lactate/Pyruvate (L/P)Ratio — 103.1; 33.8 ratio
Phase 4 N=56 Ketamine and Propofol for Upper Endoscopy
Anesthesia
Primary: Dose of Propofol Required to Prevent Movement (Response) to Insertion of Endoscope Into the Patient's Esophagus — 6.1; 4.5; 4.7; 1.1 mg/kg
N/A N=11 Sedation in Patients at Risk for Upper Airway Collapse
Obstructive Sleep Apnea
Primary: Respiratory Disturbance Index — 57.52; 21.32 events per hour
Phase 4 N=20 Stress During Deep Sedation With Propofol With and Without Alfentanil
Sedation
Primary: Change in Serum Catecholamines — 87; 106 mcg/ml — p=0.940
Phase 4 N=100 Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)
Sedation
Primary: Respiratory Depression (Sub-clinical and Clinical Signs) — 0.4; 0.6 percentage of participants
Phase 3 N=80 Propofol in Obese Children
Pharmacodynamics · Obesity
Primary: Dose of Propofol That Caused Loss of Consciousness in 95% (ED95) of Obese and Non-obese Children — 2; 2.125 mg/kg
Phase 3 N=183 Ketamine Versus Co-administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department
Procedural Sedation and Analgesia
Primary: Frequency of Adverse Events — 12; 15; 1; 0 participants
Phase 4 N=271 Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
Procedural Sedation
Primary: Clinical Interventions During Sedation — 41; 33; 48 Clinical interventions performed
Phase 4 N=50 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block
Shoulder Pain
Primary: Number of Participants That Need an Airway Intervention. — 0; 5 participants
Phase 4 N=798 Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Heart Disease
Primary: Number of Patients With Atrial Arrhythmia — 121; 134 Participants — p=0.34
Phase 4 N=135 Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy
Procedural Sedation
Primary: Level of Sedation Throughout the Entire Procedure — 22; 9; 10; 1 participants
N/A N=135 Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.
Atrial Fibrillation
Primary: Procedure Duration — 159.2; 170.7 minutes
Phase 4 N=114 Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
Colonoscopy
Primary: Percentage of Subjects Ready for Discharge in Each Group at 30 Minutes Post Procedure — 26; 44 Participants