Phase 4 N=50 A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients
Tracheal Extubation
Primary: Mean Arterial Pressure Changes During Extubation — 94; 97; 96; 97 mmHg
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Phase 1 N=30 Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool
Airway Extubation
Primary: Evaluate Feasibility of Enrolling and Consenting Greater Than 50% of Eligible Patients — 30 Participants
N/A N=67 Extubation With or Without Spontaneous Breathing Trial
Respiratory Failure
Primary: Number of Participants With Successful Extubation, Reintubation and in Hospital Mortality — 28; 29; 3; 3 participants — p=>0.05
N/A N=65 Assessment of an Endotracheal Tube Securement Device
Respiratory Insufficiency
Primary: Prevention of Damage and/or Occlusion of Endotracheal (ET) Tube During Use — 0; 1 participants
Phase 4 N=195 Does Deflating the Tracheal Cuff Shorten Weaning Time?
Weaning · Tracheostomy
Primary: Weaning Time — 4.95; 10.15; 4.95; 10.15 day
Phase 4 N=302 Residual Curarization and Its Incidence at Tracheal Extubation (P08194)
Observation of Neuromuscular Block
Primary: Percentage of Participants With Residual Neuromuscular Blockade (NMB)(Train of Four [TOF] Ratio <0.9) at Time of Tracheal Extubation — 56 percentage of participants
N/A N=52 Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure
Respiratory Failure
Primary: Neuroventilatory Efficiency (NVE) — 17.6; 39.9 ml/uV — p=<0.05
N/A N=470 Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure
Weaning Failure
Primary: Number of Patients With Extubation Failure — 58; 24 Participants
N/A N=90 Tracheal Palpation of Sliding Cuff to Assess Endotracheal Tube Location
Anesthesia Intubation Complication
Primary: Sore Throat — 1.5; 0.6 units on a scale — p=0.04
Phase 4 N=62 Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia
Deep Extubation
Primary: Awakening Time — 10; 7 minutes
N/A N=72 Comparison Between Etview Tracheoscopic Ventilation Tube - TVT to Standard Endotracheal Intubation
Endotracheal Intubation
Primary: In the Present Study we Will Compare the Performance Parameters of Intubation Using Etview Tracheoscopic Ventilation Tube - TVT to the Standard Tube
Phase 4 N=80 Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery
Brain Neoplasm
Primary: Haemodynamic Parameters at the Time of Emergence and Postextubation — 128.55; 132.34; 132.63; 134.29 mm Hg
N/A N=30 Anesthesia With Endotracheal Laser Tube
Anesthesia · Anesthesia Morbidity
Primary: Number of Participants With Side Effects — 0 participants
N/A N=80 The Influence of Endotracheal Tube Design on Fluid Leakage Into the Lungs During Surgery
Respiratory Aspiration
Primary: Number of Participants With Dye Leakage — 3; 2 participants
N/A N=751 Protocolized Post-Extubation Respiratory Support Study
Mechanical Ventilation Complication · Acute Respiratory Failure · Intubation Complication
Primary: Reintubation — 57; 52 Participants
N/A N=23 Dexmedetomidine Versus Midazolam for Facilitating Extubation
Critical Illness
Primary: Time From Study Drug Initiation to Tracheal Extubation — 2.9; 3.4 days — p=0.8
N/A N=82 Role of Neutrophil Activation
Patients Requiring Endotracheal Intubation
Primary: Neutrophil Cell Counts in Tracheal Lavages — 112.02; 26.98; 61.72; 27.63 neutrophil/high powered field — p=<0.05
N/A N=100 No Post Intubation Laryngeal Symptoms
Sore-throat · Dysphonia · Dysphagia
Primary: Sore Throat on a Scale From 0 (no Sore Throat) to 10 (Worst Possible Sore Throat) — 1.85; 1.9; 1.1; 1.62 score on a scale — p=0.03
N/A N=198 Chest Tube Drainage of Transudative Pleural Effusions Hastens Liberation From Mechanical Ventilation
Liberation From Mechanical Ventilation
Primary: Total Days of Mechanical Ventilatory Support — 6.51; 4.02 days
N/A N=64 Tracheal Intubation With the Rigid Tube for Laryngoscopy- a New Method
Intubation;Difficult
Primary: Time to Tracheal Intubation With the Rigid Tube — 50.5 seconds
N/A N=60 Endotrol-tracheal Tube Assisted Endotracheal Intubation During Video Laryngoscopy
Endotracheal Intubation
Primary: Intubation Time — 60.2; 48.8; 58.6; 40.7 seconds
Phase 4 N=79 Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy
Microlaryngoscopy · Rigid Bronchoscopy
Primary: Time to Extubation After End of Procedure — 11.06; 10.36 Minutes
N/A N=170 Intubating Conditions of Neuromuscular Blockade
Endotracheal Intubation
Primary: Number of Subjects With Optimal Intubating Conditions — 61; 47 Participants — p=0.036
Phase 4 N=58 Comparison of Time to Extubation Using Sugammadex or Neostigmine
Neuromuscular Blockade · Chronic Obstructive Pulmonary Disease
Primary: Number of Minutes to Return of Baseline Muscle Tone — 3.9; 12.9 minutes
N/A N=20 Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Short Laryngologic Surgery
Laryngologic Surgical Procedures
Primary: Average Oxygen Saturation by Pulse Oximetry (SpO2) (Primary Anesthesia Outcome) — 93; 98.7 percentage of saturation (SpO2) — p=0.006
N/A N=141 Post-operative Sore Throat as Determined by Endotracheal Tube Inflation Technique
Post Operative Sore Throat · Dysphagia · Hoarseness
Primary: Incidence of Tracheopharyngeal Symptoms — 53; 49 participants
N/A N=74 Efficacy Study of a Novel Device to Clean the Endotracheal Tube
Endotracheal Extubation · Airway Obstruction · Airway Control
Primary: Percentage of Occlusion Assessed Using a High Definition Computed Tomography Imaging of the Extubated ETTs — 10.6; 17.7 percentage of occlusion
N/A N=77 Non-invasive Ventilation vs Oxygen Therapy After Extubation Failure
Respiratory Failure
Primary: Rate of Intubation — 10; 23 participants
Phase 4 N=90 Sugammadex and Decreased Time to Extubation
Coronary Artery Bypass Graft and/or Aortic Valve Replacement Surgery
Primary: Time to Extubation — 126.0; 219.0 minutes
N/A N=20 Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Laser Laryngeal Surgery
Otorhinolaryngologic Surgical Procedures · Laser Therapy
Primary: Lowest Intraoperative Peripheral Oxygen Saturation (SpO2) — 97; 97 percentage of oxygen — p=0.7934