N/A N=12 Impact of CPAP Level on V/Q Mismatch in Premature Infants
Infant, Premature, Diseases · Respiratory Insufficiency Syndrome of Newborn
Primary: Ventilation/Perfusion Mismatch — 1.2 difference in right shift (kPa) — p=0.02
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=62 Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe Magnetic Resonance Imaging
Pulmonary Vascular Disease
Primary: Participants Determined to be True Positives for Pulmonary Arterial Hypertension — 10; 15; 10; 5 Participants
N/A N=1,705 ED Lung Protective Ventilation to Reduce Complications
Mechanical Ventilation · Ventilator-associated Conditions · ARDS
Primary: Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department — 171; 38 participants
N/A N=80 Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time
Mechanical Ventilation · Single-lung Ventilation · ARDS
Primary: Monitoring Capabilities of PulmoVista 500 — 0.9692; 0.9093 correlation coefficient
N/A N=219 Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study
Respiratory Failure · Mechanical Ventilation · Acute Lung Injury
Primary: To Further Characterize ED Mechanical Ventilation — 500 mL
N/A N=320 Intensive Alveolar Recruitment Protocol After Cardiac Surgery
Ventilator Induced Lung Injury · Cardiac Disease · Acute Lung Injury
Primary: Severity of Pulmonary Complications in the Post-operative Period — 15; 26 percentage of participants — p=0.016
Phase 2 N=11 Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI
Pulmonary Vascular Disease
Primary: Percent Change in Abnormal RBC Percentage — -17.7 percent change
N/A N=20 Effect of Alveolar Minute Ventilation on Respiratory Gas Heat Content
Ventilation Perfusion Mismatch
Primary: Airway Enthalpy — 32; 23 Joules/Minute
N/A N=78 AMBU Bag Manual Ventilation vs. Transport Ventilator Mechanical Ventilation for Transport
Oxygenation · Manual Ventilation · Mechanical Ventilation
Primary: The % Change in Mean Artery Blood Pressure — -3.73; 13 % change in mean artery pressure
Phase 2 N=171 Imaging Regional Lung Defect Severity
COPD
Primary: Gas Trapping Measured During Washout of the Perfluorinated Gas Mixture. — 0.718; 0.541; 0.308; 0.451 percentage of total lung volume — p=<0.0001
Phase 4 N=19 Hypoxic Pulmonary Vasoconstriction Pilot Study
Emphysema
Primary: Perfused Blood Volume Assessed for a Change in Lung Inflammation Pre and Post Dose Sildenafil Administration — 0.37; 0.42 coefficient of variation — p=<0.05
N/A N=70 The Effect of Ventilation on Cerebral Oxygenation in the Sitting Position
Cerebral Ischemia
Primary: Incidence of Cerebral Desaturation Events — 19; 3 number of events
N/A N=65 Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2
ARDS · Mechanical Ventilation Complication · Ventilator-Induced Lung Injury
Primary: Number of Participants Who Survived and Died — 1; 31; 14; 19 Participants
N/A N=566 Mode Of Ventilation During Critical IllnEss Pilot Trial
Respiratory Failure
Primary: Ventilator-free Days (VFDs) to Day 28 After Enrollment — 23; 22; 24 Ventilator-free days to day 28
N/A N=23 Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA
Obstructive Sleep Apnea · Chronic Obstructive Pulmonary Disease · Overlap Syndrome
Primary: Right Ventricular Remodeling Index — 0.3747; 0.2817 ratio
N/A N=16 Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome · ARDS
Primary: Mechanical Power — 1.87; -2.50 J/min — p=.002
Phase 3 N=350 Breath Analysis Technique to Diagnose Pulmonary Embolism
Pulmonary Embolism
Primary: Phase I: Percentage Change in the Postoperative End Tidal CO2/O2 Ratio and D-dimer Concentration Relative to the Preoperative Measurement — 0; 136 percent change
N/A N=20 EPO2-PV: Evaluation of Pre-Oxygenation Conditions in Morbidly Obese Volunteer: Effect of Position and Ventilation Mode
Morbid Obesity · Bariatric Surgery Candidate
Primary: Functional Residual Capacity — 2573; 2145; 2456; 2219 ml
N/A N=49 Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms
Lung Collapse · One-Lung Ventilation · Thoracic Surgery
Primary: Quantification of Gas Volume Coming From Ambient Air Towards the Alveoli Space of the Non-ventilated Lung During OLV With the Use of DLT and BB. — 504; 630 milliliters…
N/A N=26 Volume Guarantee Ventilation in Preterm Infants With Frequent Episodes of Hypoxemia
Episodic Hypoxemia in Mechanically Ventilated Preterm Infants
Primary: Percentage of Time Spent With Arterial Oxygen Saturation < 75% — 5; 4.4 % of time — p=0.44
Early Phase 1 N=11 Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study
Pulmonary Disease, Chronic Obstructive · E-cigarettes
Primary: Pulmonary Microvascular Blood Flow (PMBF), Measured on Gadolinium-enhanced MRI, Between E-cigarette Exposed and Unexposed Conditions — 74.4; 63.1 mL(blood)/min/mL(lung)…
Phase 2 N=15 Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency
Alpha-1 Antitrypsin Deficiency · Emphysema · Chronic Obstructive Pulmonary Disease
Primary: Pulmonary Microvascular Blood Flow, Mean — 36.9; 35.1 mL blood/minute per 100mL lung — p=0.692
N/A N=2,541 Pragmatic Investigation of optimaL Oxygen Targets Trial
Respiratory Failure
Primary: Ventilator-free Days (VFDs) to Study Day 28 — 20; 21; 21 number of days
N/A N=2,860 Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project
Orthopedic Surgery · Ventilation
Primary: Time-weighted Average SaO2/FiO2 Ratio in the Postanesthesia Care Unit (PACU) — 355; 350; 353; 352 ratio — p=0.042
Phase 4 N=129 Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema
Acute Cardiogenic Pulmonary Edema
Primary: Number of Patients Who Were Intubated — 5; 4; 10 participants
N/A N=30 Pilot Evaluation Comparing Regional Distribution of Ventilation During Lung Expansion Therapy
Ventilation · Breathing · Atelectasis
Primary: Regional Distribution of Ventilation — -4.9; -5.6 percentage of dorsal redistribution — p=.90
Phase 3 N=20 Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI
COPD
Primary: Ventilation Distribution as Measured by Ventilation Defect+Low Percent — 57.8; 52.5 percentage of total ventilation — p=0.006
Phase 3 N=38 Hyperpolarized Xenon MRI for Assessment of Pulmonary Function in Lung Resection
Pulmonary Surgical Procedures
Primary: Predicted Percentage of Remaining Pulmonary Function — 73.4; 71.9 percentage of remaining function
N/A N=139 Non-Contrast 4DCT to Detect Pulmonary Thromboembolic Events
Pulmonary Thromboembolisms · Pulmonary Embolism
Primary: Correlation of 4DCT Identified Perfusion With SPECT/CT Identified Perfusion — 0.45 Spearman correlation
N/A N=60 Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive
Primary: Flow-Mediated Dilation (FMD) — 3.1; 6.7; 4.7; 6.9 percentage of change in FMD — p=<0.05