Intra-arterial alteplase and tenecteplase improve excellent functional outcomes after endovascular thrombectomy for stroke
Adding certain clot-busting drugs improves outcomes for stroke patients
This network meta-analysis of 2,131 patients with acute ischemic stroke caused by large-vessel occlusion found that intra-arterial thromboly…
Combining mechanical removal of blood clots with specific medications can significantly improve recovery for patients with severe strokes.
Trial protocol for intra-arterial alteplase in anterior circulation large-vessel occlusion ischaemic stroke
Trial Plans to Test Intra-arterial Alteplase for Ischaemic Stroke
This Phase 3 randomized controlled trial protocol describes the evaluation of intra-arterial thrombolysis with alteplase in patients with ac…
A new large-scale study in France aims to determine if injecting alteplase directly into a blocked artery improves outcomes for stroke patie…
Bridging therapy increases parenchymal hemorrhage risk by 2.36 OR in patients with BGI
Bridging therapy may increase bleeding risk for some stroke patients
This post hoc secondary analysis of an RCT involving 607 patients with large-vessel occlusion acute ischemic stroke found that bridging ther…
A new analysis shows that bridging therapy with alteplase can significantly increase the risk of brain bleeding specifically for patients wi…
DAPT and aspirin show potential for managing minor acute ischemic stroke based on SUCRA rankings
Best stroke treatment may depend on your goal
This network meta-analysis of 26,176 patients evaluated 9 antithrombotic interventions for minor acute ischemic stroke. The analysis suggest…
For minor stroke, the best treatment varies by what matters most: quick recovery, preventing another stroke, or avoiding bleeding.
Tenecteplase shows no significant difference in serious adverse event distribution compared to alteplase
Trial shows tenecteplase is as safe as alteplase for stroke
This multicenter Phase 3 randomized controlled trial post-hoc analysis involved 1577 ischemic stroke patients presenting within 4.5 hours of…
A large study of over 1,500 patients confirms that the clot-busting drug tenecteplase has a similar safety profile to the standard treatment…
Thrombectomy plus intra-arterial alteplase increases excellent functional outcome to 57.5% at 90 days
Adding Alteplase to Thrombectomy Improves Stroke Recovery in This Trial
This randomized, open-label trial with blinded outcome assessment in 440 patients with acute ischemic stroke found that adding intra-arteria…
A Spanish trial found adding intra-arterial alteplase to thrombectomy increased excellent recovery rates without significantly raising bleed…
Extended-window alteplase increases functional outcomes but raises hemorrhage risk in acute ischemic stroke patients
Giving clot-busting drugs beyond 4.5 hours raises bleeding risk but may improve function
This meta-analysis of 2,050 adults shows intravenous alteplase beyond 4.5 hours improves functional scores but significantly increases sympt…
A large review of 2,050 stroke patients found higher bleeding risk with late clot-busting drugs, though some functional gains appeared.
Ultrasound-facilitated catheter-directed alteplase reduces early recurrence in intermediate-risk pulmonary embolism
New trial shows ultrasound-guided clot-busting drugs help some patients with serious lung clots recover faster and safely
This randomized controlled trial evaluated ultrasound-facilitated, catheter-directed fibrinolysis with alteplase plus anticoagulation versus…
A large study found that using ultrasound to guide clot-busting medicine helped patients with serious lung clots avoid bad outcomes. The tre…
Network meta-analysis compares alteplase, tenecteplase, and JX10 for acute ischemic stroke treatment outcomes
New analysis compares three clot-busting drugs for stroke patients treated up to twenty-four hours after symptoms start
This network meta-analysis evaluated intravenous thrombolytic agents for acute ischemic stroke. Alteplase significantly improved functional …
A large review found one standard drug helped more patients walk again than usual care, while a new drug showed promise but needs more testi…
Tenecteplase linked to higher thrombus migration than alteplase in acute ischemic stroke with EVT
Tenecteplase linked to more clot movement than alteplase in stroke patients
This secondary analysis of a randomized controlled trial in 496 patients with intracranial occlusion found that IV tenecteplase was associat…
A study found tenecteplase caused more clot movement than alteplase in stroke patients. This movement was tied to better recovery odds.
Argatroban plus alteplase shows no daytime benefit but nighttime association with better stroke outcomes
Stroke drug works better at night than in the morning
This post hoc analysis of a phase 3 RCT in 692 patients with acute ischemic stroke found no significant difference in excellent functional o…
Nighttime stroke treatment with argatroban plus alteplase may improve recovery, while daytime use showed no added benefit.
Meta-analysis suggests idarucizumab-enabled thrombolysis is feasible for dabigatran-treated stroke patients after AF ablation
Reversing blood thinners may allow stroke treatment with good safety and recovery
This meta-analysis and case report review examines idarucizumab-enabled intravenous thrombolysis in dabigatran-treated patients with peripro…
Reversing dabigatran before stroke treatment appears safe, showing low bleeding and death rates with recovery similar to standard care.
All alteplase Articles
- Intra-arterial alteplase and tenecteplase improve excellent functional outcomes after endovascular thrombectomy for stroke
- Trial protocol for intra-arterial alteplase in anterior circulation large-vessel occlusion ischaemic stroke
- Bridging therapy increases parenchymal hemorrhage risk by 2.36 OR in patients with BGI
- DAPT and aspirin show potential for managing minor acute ischemic stroke based on SUCRA rankings
- Tenecteplase shows no significant difference in serious adverse event distribution compared to alteplase
- Thrombectomy plus intra-arterial alteplase increases excellent functional outcome to 57.5% at 90 days
- Extended-window alteplase increases functional outcomes but raises hemorrhage risk in acute ischemic stroke patients
- Ultrasound-facilitated catheter-directed alteplase reduces early recurrence in intermediate-risk pulmonary embolism
- Network meta-analysis compares alteplase, tenecteplase, and JX10 for acute ischemic stroke treatment outcomes
- Tenecteplase linked to higher thrombus migration than alteplase in acute ischemic stroke with EVT
- Argatroban plus alteplase shows no daytime benefit but nighttime association with better stroke outcomes
- Meta-analysis suggests idarucizumab-enabled thrombolysis is feasible for dabigatran-treated stroke patients after AF ablation
- Meta-analysis models cost-effectiveness of IV alteplase plus thrombectomy for large vessel occlusion stroke
- Cortical Superficial Siderosis Burden Predicts Hemorrhage and Poor Outcomes After Stroke Thrombolysis
- Marked hyperglycemia linked to higher parenchymal hematoma risk with bridging therapy versus direct EVT in stroke
- Reteplase and non-immunogenic staphylokinase show superior functional outcomes vs alteplase in AIS within 4.5h