Trial protocol for intra-arterial alteplase in anterior circulation large-vessel occlusion ischaemic stroke
Trial Plans to Test Intra-arterial Alteplase for Ischaemic Stroke
This Phase 3 randomized controlled trial protocol describes the evaluation of intra-arterial thrombolysis with alteplase in patients with ac…
A new large-scale study in France aims to determine if injecting alteplase directly into a blocked artery improves outcomes for stroke patie…
Route 92 Reperfusion System increases first-pass effect and near-complete reperfusion in acute ischemic stroke
Route 92 System Shows Better Blood Flow in Stroke
This meta-analysis of 7 studies evaluated the Route 92 Reperfusion System for patients with large vessel occlusion. The analysis found signi…
A new analysis shows the Route 92 Reperfusion System achieves higher first-pass effect and better blood flow for patients with large vessel …
Systematic review and meta-analysis on EVT for anterior circulation LVO with low ASPECTS
Stroke patients regain independence years after clot removal procedure
This systematic review and meta-analysis synthesized evidence on endovascular thrombectomy for patients with anterior circulation large vess…
A clot-removal procedure that already helps severe stroke patients at 90 days now shows those benefits hold strong for a full year or more.
Meta-analysis shows bridging therapy improves outcomes versus endovascular thrombectomy alone in large-vessel occlusion stroke
Bridging Therapy Boosts Stroke Recovery Without Extra Bleed Risk
This systematic review and meta-analysis evaluated bridging therapy versus endovascular thrombectomy alone in patients with acute ischemic s…
Adding clot-busting medicine before surgery helps stroke patients recover better without raising bleeding risks in the brain.
Narrative review suggests endovascular therapy is preferable for persistent primitive hypoglossal artery lesions
Endovascular therapy works better than open surgery for patients with rare brain artery issues
This narrative review examines patients with persistent primitive hypoglossal artery and associated vascular pathologies. The authors synthe…
Patients with rare brain artery problems often need special treatment. Endovascular methods are safer and easier than open surgery for fixin…
A prediction model for futile reperfusion after endovascular thrombectomy in large vessel occlusion stroke
New Model Predicts Futile Stroke Reperfusion After Clot Removal
This retrospective cohort study developed a model using clinical, imaging, and laboratory markers to predict futile reperfusion after endova…
A new tool combining clinical, imaging, and lab data can predict which stroke patients may not benefit from clot removal.
Deep-learning model detects hyperdense artery sign on non-contrast CT in suspected stroke patients
AI Spots Hidden Stroke Clots Minutes Faster on Brain Scans
This multicenter cohort study evaluated an automated deep-learning model for hyperdense artery sign detection on non-contrast CT scans in…
This AI could give hospitals a critical head start in treating the most dangerous type of stroke, saving precious brain tissue and improving…
Meta-analysis models cost-effectiveness of IV alteplase plus thrombectomy for large vessel occlusion stroke
Adding alteplase to stroke surgery is cost-effective when treatment starts within 170 minutes
This meta-analysis models cost-effectiveness using individual patient data from 6 trials involving 2,268 patients across 16 countries.
Adding clot-busting medicine to stroke surgery saves money and improves value when treatment starts within 170 minutes, but benefits fade af…
Early EVT within 6 hours linked to lower mortality, better functional outcomes versus later EVT in large vessel occlusion stroke
Does getting clot-busting treatment sooner save lives and improve recovery for stroke patients?
A meta-analysis of 18 studies in patients with acute ischemic stroke due to large vessel occlusion found early endovascular thrombectomy (≤6…
Stroke patients treated with clot-removal surgery within six hours face lower death rates and better recovery chances than those treated lat…
Direct Transfer to Angiography Suite Shows No Benefit, Higher Hemorrhage Risk in Severe Stroke
Does rushing stroke patients straight to treatment improve their recovery?
A randomized trial in 115 adults with acute severe stroke from large vessel occlusion compared direct transfer to angiography suite (DTAS) w…
Skipping the CT scan to rush stroke patients straight to treatment did not improve recovery and increased the risk of serious brain bleeding…
Questions about Large Vessel Occlusion
Is direct transfer to angiography suite better for severe large vessel occlusion stroke?
Direct transfer to an angiography suite for severe large vessel occlusion stroke does not improve long-term recovery and may increase the risk of bleeding complications.
Full answer →How can doctors predict if large vessel occlusion stroke treatment will be futile?
Doctors use clinical scores, imaging, and biomarkers to predict futile LVO stroke treatment, but no single tool is perfect.
Full answer →Can endovascular thrombectomy help patients with large vessel occlusion and low ASPECTS?
Yes, recent trials show endovascular thrombectomy improves functional outcomes in patients with large vessel occlusion and low ASPECTS (≤5), though risks remain.
Full answer →