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Home › Medications › azithromycin

azithromycin

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of azithromycin

66 trials tracked of azithromycin: 37 in phase 3 or 4 and 23 with published results. The most-cited published study has 265 citations.

66Trials tracked
37Phase 3 & 4
0Recruiting
23With published results
Phase distribution
Phase 4 23 Phase 3 14 Phase 2 15 Phase 1 4 Other / NA 10
  1. Phase 3 Treatment of Preschool Children With Upper Respiratory Tract Illnesses Using Azythromycin and Lower Respiratory Tract Symptoms Using Oral Corticosteroids. Completed · 265 cited
  2. Phase 4 Lipids of the Human Tear Film and Their Effect on Tear Stability Completed · 168 cited
  3. Phase 3 OPTIMIZing Treatment for Early Pseudomonas Aeruginosa Infection in Cystic Fibrosis Completed · 98 cited
  4. Phase 4 Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia Completed · 90 cited
  5. Phase 4 Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM Completed · 78 cited
  6. Phase 4 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Completed · 71 cited
Show 44 more trials
  1. Phase 3 AZMATICS: AZithroMycin/Asthma Trial In Community Settings Completed · 69 cited
  2. Phase 4 Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso Completed · 61 cited
  3. Phase 3 A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea Completed · 60 cited
  4. Phase 4 Mortality Reduction After Oral Azithromycin: Mortality Study Completed · 45 cited
  5. Phase 4 Azithromycin for Child Survival in Niger: Mortality and Resistance Trial Completed · 42 cited
  6. Phase 4 Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso Completed · 40 cited
  7. Phase 4 Partnership for Rapid Elimination of Trachoma Completed · 33 cited
  8. Phase 3 Comparison of Two Different Doses of Azithromycin for Treatment of Yaws Completed · 28 cited
  9. Phase 3 Zoliflodacin in Uncomplicated Gonorrhoea Completed · 25 cited
  10. Phase 4 MORDOR II Burkina Faso: Longitudinal Trial Completed · 13 cited
  11. Phase 3 Azithromycin-Prevention in Labor Use Study (A-PLUS) Completed · 11 cited
  12. Phase 3 Azithromycin for Uncomplicated Severe Acute Malnutrition in Burkina Faso (Pilot) Completed · 9 cited
  13. Phase 4 Gut and Azithromycin Mechanisms in Infants and Children II Completed · 5 cited
  14. Phase 4 Azithromycin Reduction to Reach Elimination of Trachoma Completed · 5 cited
  15. Phase 3 Validation of Patient Reported Outcome Measures in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex Completed · 2 cited
  16. Phase 4 Community Health Azithromycin Trial in Burkina Faso Completed · 1 cited
  17. Phase 4 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Completed
  18. Phase 4 Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis Completed
  19. Phase 4 Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With Cystic Fibrosis (CF) Completed
  20. Phase 4 Mortality Reduction After Oral Azithromycin Contingency: Mortality Study Completed
  21. Phase 4 Trial Comparing Ceftriaxone Plus Azithromycin Versus Ceftriaxone for the Treatment of Gonorrhea Completed
  22. Phase 4 Study of AzaSite (Azithromycin) Versus Vigamox in the Conjunctiva of Healthy Volunteers Completed
  23. Phase 4 Efficacy of Combination Therapies for Gonorrhea Treatment Completed
  24. Phase 4 Efficacy of Azithromycin in Treatment of Bronchiectasis Completed
  25. Phase 4 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed
  26. Phase 4 Azithromycin in Bronchiolitis Obliterans Syndrome Completed
  27. Phase 3 The Study Of Azithromycin Switch Therapy For Treatment Of Community Acquired Pneumonia (CAP) Completed
  28. Phase 3 Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA) Completed
  29. Phase 3 Chloroquine Alone or in Combination for Malaria in Children in Malawi Completed
  30. Phase 3 Study Of Azithromycin Intravenous Formulation Against Pelvic Inflammatory Disease (PID) In Japan Completed
  31. Phase 3 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities Completed
  32. Phase 2 Oral Azithromycin Versus Doxycycline in Posterior Blepharitis Completed
  33. Phase 2 Front Line Ibrutinib Without Corticosteroids for Newly Diagnosed Chronic Graft-versus-Host Disease Completed
  34. Phase 2 Targeted Therapy of Bronchiolitis Obliterans Syndrome Completed
  35. Phase 2 Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19 Completed
  36. Phase 2 Trial of Intravenous Azithromycin to Eradicate Ureaplasma Respiratory Tract Infection in Preterm Infants Completed
  37. Phase 2 YCFM (Youth Correctional Facilities Males) Completed
  38. Phase 2 Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis Completed
  39. Phase 2 Antibiotic Treatment Trial for the PANDAS/PANS Phenotype Completed
  40. Phase 2 Efficacy and Safety Assessment of Azyter® Eye Drops (T1225) in Patients With Blepharitis Completed
  41. Phase 2 Pertussis Challenge Study in Adults Vaccinated With BPZE1 Completed
  42. Phase 2 Personalized Treatment Algorithms for Difficult-to-treat Asthma Completed
  43. Phase 2 Preschool Wheeze: Inflammation/Infection Guided Management Completed
  44. Phase 2 NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) Completed

Showing the 50 most-cited and recently-updated of 66 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Quadruple antimycobacterial regimen achieves clinical stability in cystic fibrosis patient with M. abscessus
Pediatrics Sys. Review
Quadruple antimycobacterial regimen achieves clinical stability in cystic fibrosis patient with M. abscessus Case report shows quadruple regimen for cystic fibrosis infection
A case report and literature review describes a 21-year-old man with cystic fibrosis and Mycobacterium abscessus infection who achieved clin…
A young man with cystic fibrosis and a hard-to-treat infection achieved stability using a four-drug antimycobacterial regimen.
Frontiers Jun 2, 2026
Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
Infectious Disease RCT
Azithromycin reduces maternal infection in laboring women in low- and middle-income countries Antibiotic reduces maternal infection risk in labor
This secondary analysis of an RCT found that azithromycin reduced maternal infection and sepsis in women in labor, with a larger reduction a…
A single dose of azithromycin during labor lowered maternal infections in a large trial across seven countries.
Jun 1, 2026
Azithromycin at discharge does not reduce pneumococcal carriage in Kenyan children
Pediatrics RCT
Azithromycin at discharge does not reduce pneumococcal carriage in Kenyan children A Single Dose Does Not Boost Drug Resistance
A randomized trial found a 5-day azithromycin course at hospital discharge did not lower pneumococcal carriage or resistance rates in Kenyan…
Giving a five-day course of azithromycin to children leaving the hospital did not increase drug resistance or change bacteria levels.
May 15, 2026
Meta-analysis shows integrated MDA reduces yaws attendances in Papua New Guinea
Infectious Disease Meta-analysis
Meta-analysis shows integrated MDA reduces yaws attendances in Papua New Guinea Four-drug treatment lowered yaws cases in Papua New Guinea communities significantly
This comparative observational study and systematic review with network meta-analysis evaluates yaws control strategies in under-reached com…
A new review shows that giving four medicines together greatly reduced yaws cases in Papua New Guinea. People saw fewer skin problems and fe…
May 14, 2026
Meta-analysis finds 22.5% prevalence of Neisseria gonorrhoeae and high resistance to tetracycline, ciprofloxacin, and penicillin in Kenya
Infectious Disease Meta-analysis
Meta-analysis finds 22.5% prevalence of Neisseria gonorrhoeae and high resistance to tetracycline, ciprofloxacin, and penicillin in Kenya Kenya's Silent Gonorrhea Crisis Demands New Solutions Now
This systematic review and meta-analysis of 5,170 participants in Kenya found a pooled prevalence of Neisseria gonorrhoeae of 22.5%. Resista…
• Gonorrhea affects one in four high-risk Kenyans tested • Sex workers and low-education groups face highest danger • New treatments like ph…
May 5, 2026
Systematic review and meta-analysis compares oral azithromycin and doxycycline for moderate to severe acne
Infectious Disease Meta-analysis
Systematic review and meta-analysis compares oral azithromycin and doxycycline for moderate to severe acne Azithromycin may work better than doxycycline for some acne cases
This systematic review and meta-analysis synthesized evidence on oral azithromycin pulse therapy versus doxycycline for moderate to severe a…
A new review finds azithromycin pulse therapy may improve acne more than doxycycline, with fewer side effects for some patients.
May 5, 2026
Azithromycin to doxycycline switching in children with Mycoplasma pneumoniae pneumonia resistance gene positivity
Pediatrics Cohort
Azithromycin to doxycycline switching in children with Mycoplasma pneumoniae pneumonia resistance gene positivity Testing for resistance genes may guide antibiotic choices
This retrospective cohort study of 150 children with Mycoplasma pneumoniae pneumonia evaluated resistance gene expression and antibiotic man…
New evidence suggests that checking for resistance genes in children with pneumonia could help doctors decide when to switch antibiotics.
Frontiers Apr 30, 2026
Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants
Pediatrics RCT
Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants Azithromycin in Labor Raises Short-Term Resistance Risk
This RCT sub-study of 911 women and 915 infants found that prophylactic oral azithromycin during labor increased azithromycin resistance in …
This could change how we balance infection protection and antibiotic safety in childbirth.
Apr 23, 2026
Macrolide-resistant Mycoplasma pneumoniae prevalence at 94% in pediatric CAP cohort
Pediatrics Cohort
Macrolide-resistant Mycoplasma pneumoniae prevalence at 94% in pediatric CAP cohort Resistant pneumonia keeps kids sicker for days
This retrospective cohort of 71 pediatric patients in China found a 94.4% prevalence of macrolide-resistant M.
In one Chinese hospital, 94% of child pneumonia cases resisted common antibiotics, leading to longer fevers and hospital stays.
Frontiers Apr 23, 2026
ALIS plus macrolide regimen improves culture conversion in noncavitary MAC lung disease
Infectious Disease RCT
ALIS plus macrolide regimen improves culture conversion in noncavitary MAC lung disease An Inhaled Antibiotic Shifts the Odds in a Stealthy Lung Infection
In a 99-patient RCT of adults with noncavitary MAC lung disease, adding 6 months of amikacin liposome inhalation suspension (ALIS) to a macr…
Adding a nebulized antibiotic to standard pills helped more newly diagnosed MAC lung patients clear the bug sooner, with no new safety surpr…
Apr 13, 2026
Doxycycline-Quinolone Sequential Therapy Shows Lower Failure, Recurrence vs Azithromycin for MG
Infectious Disease Cohort
Doxycycline-Quinolone Sequential Therapy Shows Lower Failure, Recurrence vs Azithromycin for MG A New Strategy Cures a Stubborn STD Faster and Prevents Its Return
A retrospective cohort study of 1,192 NAAT-confirmed MG patients at a Chinese tertiary hospital found doxycycline-quinolone sequential thera…
Doctors now have clearer evidence for a better treatment plan to defeat a common, often-missed sexually transmitted infection.
Frontiers Apr 10, 2026
Retrospective study links IVIG plus azithromycin to higher response rate in pediatric Mycoplasma pneumoniae pneumonia
Pulmonology & Critical Care Cohort
Retrospective study links IVIG plus azithromycin to higher response rate in pediatric Mycoplasma pneumoniae pneumonia When a Child's Pneumonia Won't Clear, This Add-On May Help
A single-center retrospective cohort of 140 children with Mycoplasma pneumoniae pneumonia found that adding intravenous immunoglobulin (IVIG…
Adding donor antibodies to standard antibiotics helped 97% of children with stubborn pneumonia recover, compared to 84% on antibiotics alone…
Frontiers Apr 9, 2026

All azithromycin Articles