Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Staphylococcus aureus

Staphylococcus aureus

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Staphylococcus aureus

10 trials tracked for Staphylococcus aureus: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 37 citations.

10Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 2 Other / NA 5
  1. Phase 4 Mupirocin-Iodophor ICU Decolonization Swap Out Trial Completed · 37 cited
  2. Phase 3 Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery Completed · 8 cited
  3. Phase 4 Staph Household Intervention for Eradication (SHINE) Completed
  4. Phase 2 Staphylococcus Aureus Toxoids Phase 1-2 Vaccine Trial Completed
  5. Phase 2 Study Evaluating Safety, Tolerability, and Efficacy of Intravenous AP-SA02 in Subjects With S. Aureus Bacteremia Completed
  6. N/A The Natural History of Community-Associated MRSA Infections and Decolonization Strategies Completed
Show 4 more trials
  1. N/A Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees Completed
  2. N/A Individualized vs. Household MRSA Decolonization Completed
  3. N/A Staphylococcus Aureus Decolonization Study Completed
  4. N/A Preventing the Spread of Infection in Nursing Homes Completed

Showing the 10 most-cited and recently-updated of 10 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Staphylococcus aureus: what the trials found

Chlorhexidine is established as a treatment for Staphylococcus aureus management 1. Routine care involving Mupirocin and Chlorhexidine Gluconate (CHG) has been evaluated in large-scale populations 3.

Daptomycin is an established intervention for this condition 4. Additionally, 2% mupirocin ointment was studied for decolonization; however, there was no statistically significant difference in the incidence of skin and soft tissue infections (SSTI) at 1 month (p=1.00), 3 months (p=0.757), or 6 months (p=0.687) following treatment 7.

The use of 2% mupirocin ointment for decolonization showed no statistically significant difference in eradication rates at 1 month (p=1.00), 3 months (p=0.05), or 6 months (p=0.49) 10.

Recent results — preliminary, needs further review

  • AP-SA02 was evaluated for safety and tolerability, with no significant difference in treatment-emergent adverse events (p=0.25) 2.
  • Clinical improvement or response at 7 days after antibiotic therapy following AP-SA02 administration showed results of 21 vs 6 as assessed by the investigator and 21 vs 7 as assessed by the CEAC 2.

For the clinician treating this condition

  • Chlorhexidine and Mupirocin (either alone or in combination) are established components of management and decolonization protocols [1, 3].
  • Daptomycin is an established intervention for Staphylococcus aureus 4.
  • While mupirocin ointment was used for decolonization, trials did not find a statistically significant difference in the incidence of SSTIs at various follow-up intervals or in eradication rates at specific time points [7, 10].

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants
Pediatrics RCT
Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants Azithromycin in Labor Raises Short-Term Resistance Risk
This RCT sub-study of 911 women and 915 infants found that prophylactic oral azithromycin during labor increased azithromycin resistance in …
This could change how we balance infection protection and antibiotic safety in childbirth.
Apr 23, 2026