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Home › Medications › binimetinib

binimetinib

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of binimetinib

15 trials tracked of binimetinib: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 562 citations.

15Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 9 Phase 1 4 Other / NA 1
  1. Phase 3 Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer Completed · 562 cited
  2. Phase 2 Study of Binimetinib + Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Microsatellite-stable (MSS) Metastatic Colorectal Cancer With RAS Mutation Completed
  3. Phase 2 Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer Completed
  4. Phase 2 Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer Completed
  5. Phase 2 A Study of Binimetinib and Encorafenib in Advanced BRAF Mutant Cancers Completed
  6. Phase 2 An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer Completed
Show 9 more trials
  1. Phase 2 Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the Brain Completed
  2. Phase 2 Pembrolizumab and Binimetinib in Treating Patients With Locally Advanced or Metastatic Triple Negative Breast Cancer Completed
  3. Phase 2 Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas Completed
  4. Phase 2 Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer Completed
  5. Phase 1 Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors Completed
  6. Phase 1 Safety and Efficacy of Pembrolizumab (MK-3475) Plus Binimetinib Alone or Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Metastatic Colorectal Cancer (mCRC) Participants (MK-3475-651/KEYNOTE-651) Completed
  7. Phase 1 A Phase I/Ib Study of MEK162, a MEK Inhibitor, in Combination With Carboplatin and Pemetrexed in Patients With Non-squamous Carcinoma of the Lung Completed
  8. Phase 1 MEK and MET Inhibition in Colorectal Cancer Completed
  9. N/A Comparative Effectiveness of Targeted Therapies in BRAF Positive Metastatic Melanoma in the US Completed

Showing the 15 most-cited and recently-updated of 15 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Encorafenib and Binimetinib Combination Therapy for Patients with BRAF Mutated Cutaneous Melanoma
Oncology RCT
Encorafenib and Binimetinib Combination Therapy for Patients with BRAF Mutated Cutaneous Melanoma Trial Shows Encorafenib and Binimetinib for Melanoma Patients
This trial evaluates the safety and efficacy of encorafenib and binimetinib in patients with resected stage IIB/IIC melanoma.
A clinical trial shows that a combination of encorafenib and binimetinib may improve recurrence-free survival for patients with specific mel…
Sep 11, 2026
Encorafenib plus binimetinib maintains quality of life in BRAF V600E-mutated thyroid cancer
Oncology Phase II
Encorafenib plus binimetinib maintains quality of life in BRAF V600E-mutated thyroid cancer Can new drugs help advanced thyroid cancer patients keep their daily life stable?
An uncontrolled phase 2 trial of 22 patients with BRAF V600E-mutated thyroid cancer found encorafenib plus binimetinib was associated with g…
A new drug combination helped advanced thyroid cancer patients maintain daily life stability without worsening their quality of life during …
Apr 9, 2026
Retrospective analysis identifies molecular correlates of benefit with encorafenib-based therapy in BRAF-mutant melanoma
Dermatology RCT
Retrospective analysis identifies molecular correlates of benefit with encorafenib-based therapy in BRAF-mutant melanoma Melanoma study finds tumor genetics and immune markers may predict treatment benefit
A retrospective exploratory analysis of the phase III COLUMBUS trial in 921 patients with BRAF V600E/K-mutant advanced melanoma found that s…
Patients with advanced melanoma who have higher tumor mutational burden or signs of immune system activity gain the most survival benefit fr…
Apr 4, 2026