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Home › Medications › caffeine

caffeine

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of caffeine

24 trials tracked of caffeine: 8 in phase 3 or 4 and 1 with published results. The most-cited published study has 65 citations.

24Trials tracked
8Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 5 Phase 3 3 Phase 2 6 Phase 1 7 Other / NA 3
  1. Phase 3 Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain Completed · 65 cited
  2. Phase 4 Early Versus Routine Caffeine Administration in Extremely Preterm Neonates Completed
  3. Phase 4 A Study to Determine if Caffeine Accelerates Emergence From Anesthesia Completed
  4. Phase 4 A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia Completed
  5. Phase 4 Study to Evaluate Effect of Belatacept on Pharmacokinetics of Inje Cocktail in Healthy Volunteers Completed
  6. Phase 4 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed
Show 18 more trials
  1. Phase 3 Ibuprofen/Caffeine Lower Back or Neck Pain Study Completed
  2. Phase 3 A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo Completed
  3. Phase 2 Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury Completed
  4. Phase 2 Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study) Completed
  5. Phase 2 The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA). Completed
  6. Phase 2 Efficacy of Caffeine Injection as an Adjuvant to Opioid Therapy in Cancer Pain Completed
  7. Phase 2 Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate Completed
  8. Phase 2 Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed Completed
  9. Phase 1 Caffeine and Neurologic Recovery Following Surgery and General Anesthesia Completed
  10. Phase 1 Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors Completed
  11. Phase 1 Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4 Completed
  12. Phase 1 A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005) Completed
  13. Phase 1 A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy Participants Completed
  14. Phase 1 To Determine Blood Concentrations of Ibuprofen and Caffeine in a Tablet Against Ibuprofen Alone From Another Tablet Completed
  15. Phase 1 Drug Drug Interaction Study Between BI 201335 and BI 207127 in Chronic Hepatitis C Infected Patients Completed
  16. N/A Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT Completed
  17. N/A Effect of Oral Caffeine and L-Citrulline Supplementation on Arterial Function in Healthy Males Completed
  18. N/A A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis Completed

Showing the 24 most-cited and recently-updated of 24 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Multimodal lung-protective strategies reduce BPD risk in preterm infants
Pediatrics Sys. Review
Multimodal lung-protective strategies reduce BPD risk in preterm infants New insights into managing lung damage in preterm infants
This narrative review synthesizes evidence on bronchopulmonary dysplasia (BPD) in preterm infants, highlighting its multifactorial pathophys…
Doctors are identifying key risk factors and treatment paths for bronchopulmonary dysplasia to better protect the lungs of premature babies.
Frontiers Jul 22, 2026
Caffeine shows no ergogenic effect on sport-specific or physical performance in female volleyball players
Nutrition & Obesity Medicine Meta-analysis
Caffeine shows no ergogenic effect on sport-specific or physical performance in female volleyball players Caffeine does not improve performance for female volleyball players
This systematic review and three-level meta-analysis of 66 female volleyball players found no clear evidence that acute caffeine supplementa…
New data shows that taking caffeine before a game does not improve jumping, power, or spiking for female volleyball players.
Frontiers Jul 8, 2026
Vitamin D improves strength and reduces injuries in dancers, while iron lowers anemia prevalence
Nutrition & Obesity Medicine Meta-analysis
Vitamin D improves strength and reduces injuries in dancers, while iron lowers anemia prevalence Dancers take many supplements, but benefits are often unproven and risks remain unclear
This systematic review of dietary supplement and medication use in 654 female and 86 male professional and pre-professional dancers found vi…
Dancers use many supplements and painkillers, yet benefits are limited and potential health risks need more study before we can trust them.
Frontiers Jun 4, 2026
Meta-analysis reveals caffeine benefits for female athletes in intermittent sports regarding agility and vertical jump performance
Nutrition & Obesity Medicine Meta-analysis
Meta-analysis reveals caffeine benefits for female athletes in intermittent sports regarding agility and vertical jump performance Caffeine helps female athletes in intermittent sports improve agility and vertical jump
A systematic review of nine studies involving female athletes found that caffeine intake significantly improved agility and vertical jump. H…
A review of nine studies found that caffeine improved agility and vertical jump in female athletes doing intermittent sports, though sprint …
Frontiers May 22, 2026
Extended Caffeine Therapy Reduces Intermittent Hypoxia Burden in Very Preterm Infants in Randomized Trial
Pediatrics RCT
Extended Caffeine Therapy Reduces Intermittent Hypoxia Burden in Very Preterm Infants in Randomized Trial Giving Caffeine a Longer Ride
This randomized clinical trial enrolled 160 infants <30 weeks + 6 days gestational age to evaluate extended caffeine therapy versus placebo.
Extending caffeine treatment for premature babies until 43 weeks reduced dangerous oxygen drops and lowered inflammation markers.
Apr 19, 2026