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Home › Medications › aspirin

aspirin

31 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of aspirin

86 trials tracked of aspirin: 43 in phase 3 or 4 and 17 with published results. The most-cited published study has 2421 citations.

86Trials tracked
43Phase 3 & 4
0Recruiting
17With published results
Phase distribution
Phase 4 26 Phase 3 17 Phase 2 28 Phase 1 4 Other / NA 11
  1. Phase 3 Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease Completed · 2,421 cited
  2. Phase 4 Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study) Completed · 1,506 cited
  3. Phase 4 Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Graft Surgery Completed · 240 cited
  4. Phase 3 Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET) Completed · 172 cited
  5. Phase 4 Nephropathy In Type 2 Diabetes and Cardio-renal Events Completed · 133 cited
  6. Phase 3 Minocycline and Aspirin in the Treatment of Bipolar Depression Completed · 72 cited
Show 44 more trials
  1. Phase 3 Low Dose Aspirin for Venous Leg Ulcers Completed · 29 cited
  2. Phase 3 Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI) Completed · 24 cited
  3. Phase 4 Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor Completed · 22 cited
  4. Phase 3 Microvascular and Antiinflammatory Effects of Rivaroxaban Compared to Aspirin in Type-2 Diabetic Patients With Subclinical Inflammation and High Cardiovascular Risk Completed · 20 cited
  5. Phase 4 Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus Completed · 19 cited
  6. Phase 4 PROMUS Element Plus US Post-Approval Study Completed · 16 cited
  7. Phase 3 Comparative Efficacy of Ticagrelor Versus Aspirin on Blood Viscosity in Peripheral Artery Disease Patients With Type 2 Diabetes Completed · 13 cited
  8. Phase 4 Clopidogrel and Aspirin Interaction Study-2 Completed · 11 cited
  9. Phase 4 Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease Completed · 10 cited
  10. Phase 4 Ticagrelor Antiplatelet Therapy to Reduce Graft Events and Thrombosis Completed · 9 cited
  11. Phase 4 Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention Completed · 7 cited
  12. Phase 4 Pharmacogenomics of Antiplatelet Response - II (PARes-II) Completed
  13. Phase 4 Pharmacogenomics of Antiplatelet Response Completed
  14. Phase 4 Pharmacogenomics of Antiplatelet Response - I Completed
  15. Phase 4 DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation Completed
  16. Phase 4 Aspirin for Prevention of Venous Thromboembolism Among Ovarian Cancer Patients Receiving Neoadjuvant Chemotherapy Completed
  17. Phase 4 CES1 Carriers in the PAPI Study Completed
  18. Phase 4 The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin Completed
  19. Phase 4 Aspirin Dosing in Diabetic Patients Completed
  20. Phase 4 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed
  21. Phase 4 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed
  22. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome Completed
  23. Phase 4 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed
  24. Phase 4 Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler Completed
  25. Phase 4 Aspirin Responsiveness in Women at Risk for Cardiac Events Completed
  26. Phase 4 Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty Completed
  27. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Heart Disease Completed
  28. Phase 3 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Completed
  29. Phase 3 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Completed
  30. Phase 3 Aspirin in Young Psychotic Patients Completed
  31. Phase 3 A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia Completed
  32. Phase 3 PLATINUM Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions-Pharmacokinetics (PLATINUM PK) Completed
  33. Phase 3 A Study to Compare MPR With MP in Newly Diagnosed Multiple Myeloma Subjects 65 Years Old or Older. Completed
  34. Phase 3 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial Completed
  35. Phase 3 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions Completed
  36. Phase 3 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL) Completed
  37. Phase 3 Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer Completed
  38. Phase 2 Trial of Aspirin and Arginine Restriction in Colorectal Cancer Completed
  39. Phase 2 Prostaglandin Inhibition and Immune Checkpoint Blockade in Melanoma Completed
  40. Phase 2 Acetylsalicylic Acid and Eflornithine in Treating Patients at High Risk for Colorectal Cancer Completed
  41. Phase 2 Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes" Completed
  42. Phase 2 The Effects of DHA on Periodontitis Completed
  43. Phase 2 Targeting Platelets in Chronic HIV Infection Completed
  44. Phase 2 Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules Completed

Showing the 50 most-cited and recently-updated of 86 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Ticagrelor reduces mortality and major adverse cardiovascular events compared to clopidogrel in STEMI patients
Cardiology Meta-analysis
Ticagrelor reduces mortality and major adverse cardiovascular events compared to clopidogrel in STEMI patients Ticagrelor Shows Lower Mortality Risk Than Clopidogrel for Heart Patients
This meta-analysis of 31,729 adult STEMI patients post-PCI found that ticagrelor significantly reduced all-cause mortality (OR = 0.64) and m…
A large analysis of over 31,000 patients suggests ticagrelor may lower mortality and heart attack risks compared to clopidogrel after a hear…
NEJM Jul 26, 2026
Lower aspirin doses combined with clopidogrel may reduce ischemic events in high risk patients
Cardiology RCT
Lower aspirin doses combined with clopidogrel may reduce ischemic events in high risk patients Lower Aspirin Doses May Be Safer for Patients After Minor Strokes
Researchers analyzed data from a trial involving patients with transient ischemic attack and minor stroke receiving dual antiplatelet therap…
Doctors found that taking a lower dose of aspirin with clopidogrel may reduce the risk of serious heart and brain events.
Jul 21, 2026
Imatinib achieves complete cytogenetic response in a pediatric patient with suspected chronic myeloid leukemia
Pediatrics Sys. Review
Imatinib achieves complete cytogenetic response in a pediatric patient with suspected chronic myeloid leukemia Imatinib works for CML in child with high platelets
This case report describes a pediatric patient with isolated thrombocytosis who achieved a complete cytogenetic response to imatinib after f…
A child with high platelets and no response to standard therapy was found to have CML and responded to imatinib.
Frontiers Jul 21, 2026
Extended DAPT with clopidogrel and aspirin reduces cardiovascular death, myocardial infarction, and stroke risk
Cardiology RCT
Extended DAPT with clopidogrel and aspirin reduces cardiovascular death, myocardial infarction, and stroke risk Extended dual antiplatelet therapy lowers risks for heart disease patients
This randomized trial of 8250 patients with multivessel coronary artery disease found that extending dual antiplatelet therapy (DAPT) for an…
Patients with coronary artery disease may have lower risks of stroke and heart attack when taking two blood thinners for an extra year.
Jul 16, 2026
Apixaban reduces stroke and systemic embolism in patients with subclinical atrial fibrillation and an implantable cardiac monitor
Cardiology RCT
Apixaban reduces stroke and systemic embolism in patients with subclinical atrial fibrillation and an implantable cardiac monitor Apixaban reduces stroke risk in patients with certain heart conditions
This randomized controlled trial evaluated 4012 patients with subclinical atrial fibrillation, including a cohort of 209 with an implantable…
A new analysis shows that apixaban may significantly lower stroke risks for patients with subclinical atrial fibrillation and specific cardi…
Jul 3, 2026
Dipyridamole combined with immunoglobulin and aspirin improves clinical efficacy in children with Kawasaki disease
Rheumatology Meta-analysis
Dipyridamole combined with immunoglobulin and aspirin improves clinical efficacy in children with Kawasaki disease Dipyridamole Combined with Aspirin Improves Outcomes for Kawasaki Disease
This meta-analysis of randomized controlled trials involving 1,594 children found that adding dipyridamole to immunoglobulin and aspirin sig…
Adding dipyridamole to standard immunoglobulin and aspirin treatment may improve clinical outcomes and speed up recovery for children with K…
Frontiers Jun 29, 2026
General medical management improves medication adherence and lifestyle outcomes in older adults with type 2 diabetes
Diabetes & Endocrinology RCT
General medical management improves medication adherence and lifestyle outcomes in older adults with type 2 diabetes New management model improves medication use and health for seniors
This randomized controlled trial of 200 older adults with type 2 diabetes and atherosclerotic cardiovascular disease found that a general me…
A new personalized care plan helps older adults with diabetes and heart disease stay on their medications and improve their daily habits.
Jun 26, 2026
DAPT and aspirin show potential for managing minor acute ischemic stroke based on SUCRA rankings
Urology Meta-analysis
DAPT and aspirin show potential for managing minor acute ischemic stroke based on SUCRA rankings Best stroke treatment may depend on your goal
This network meta-analysis of 26,176 patients evaluated 9 antithrombotic interventions for minor acute ischemic stroke. The analysis suggest…
For minor stroke, the best treatment varies by what matters most: quick recovery, preventing another stroke, or avoiding bleeding.
Frontiers Jun 25, 2026
Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response
Neurology RCT
Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response Trial shows tirofiban improves outcomes for some stroke patients
Intravenous tirofiban significantly improves 90-day functional outcomes for acute ischemic stroke patients failing initial tenecteplase ther…
A new clinical trial suggests that adding tirofiban can improve recovery rates for certain types of stroke patients who do not respond well …
JAMA Jun 13, 2026
Apixaban Reduces Intracranial Bleeding Risk Compared To Aspirin In Patients With Cryptogenic Stroke And Atrial Cardiopathy Evidence
Neurology RCT
Apixaban Reduces Intracranial Bleeding Risk Compared To Aspirin In Patients With Cryptogenic Stroke And Atrial Cardiopathy Evidence Trial shows apixaban reduces intracranial bleeding risk versus aspirin in cryptogenic stroke patients
In a multicenter randomized trial of 1,015 patients, apixaban demonstrated a significant reduction in intracranial hemorrhage compared to as…
A trial of 1,015 patients found apixaban caused fewer intracranial hemorrhages than aspirin, offering safety insights for those with cryptog…
Jun 1, 2026
Early dual antiplatelet therapy improves outcomes after ischaemic stroke thrombolysis
Neurology RCT
Early dual antiplatelet therapy improves outcomes after ischaemic stroke thrombolysis Stroke Patients Gain Better Recovery With Early Double Blood Thinner Combo
A Chinese trial found that starting aspirin and ticagrelor within six hours after thrombolysis boosted excellent functional outcomes at 90 d…
Adding a second blood thinner within hours helps more stroke patients regain full function without raising bleeding risks
May 15, 2026
Narrative review suggests precision interventions for preeclampsia phenotypes
Drug Pipeline Sys. Review
Narrative review suggests precision interventions for preeclampsia phenotypes At-a-Glance
This narrative review examines prevention strategies for preeclampsia in pregnant women. The authors note that standard low-dose aspirin eff…
Preeclampsia prevention is moving beyond aspirin for everyone, with new research showing that matching treatments to a woman's specific risk…
Frontiers May 12, 2026

All aspirin Articles