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Home › Medications › aspirin

aspirin

23 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of aspirin

101 trials tracked of aspirin: 52 in phase 3 or 4 and 23 with published results. The most-cited published study has 2401 citations.

101Trials tracked
52Phase 3 & 4
0Recruiting
23With published results
Phase distribution
Phase 4 28 Phase 3 24 Phase 2 32 Phase 1 5 Other / NA 12
  1. Phase 3 Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease Completed · 2,401 cited
  2. Phase 4 Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study) Completed · 1,502 cited
  3. Phase 3 Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) Completed · 280 cited
  4. Phase 4 Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Graft Surgery Completed · 237 cited
  5. Phase 3 Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET) Completed · 171 cited
  6. Phase 3 PREVENTion of Clot in Orthopaedic Trauma Completed · 152 cited
Show 44 more trials
  1. Phase 4 Nephropathy In Type 2 Diabetes and Cardio-renal Events Completed · 129 cited
  2. Phase 3 Pharmacokinetic, Pharmacodynamic, Safety, and Efficacy Study of Rivaroxaban for Thromboprophylaxis in Pediatric Participants 2 to 8 Years of Age After the Fontan Procedure Completed · 92 cited
  3. Phase 3 Minocycline and Aspirin in the Treatment of Bipolar Depression Completed · 72 cited
  4. Phase 3 GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation Completed · 50 cited
  5. Phase 3 Low Dose Aspirin for Venous Leg Ulcers Completed · 29 cited
  6. Phase 3 Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI) Completed · 24 cited
  7. Phase 4 Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor Completed · 22 cited
  8. Phase 3 Microvascular and Antiinflammatory Effects of Rivaroxaban Compared to Aspirin in Type-2 Diabetic Patients With Subclinical Inflammation and High Cardiovascular Risk Completed · 20 cited
  9. Phase 4 Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus Completed · 19 cited
  10. Phase 4 PROMUS Element Plus US Post-Approval Study Completed · 16 cited
  11. Phase 3 Comparative Efficacy of Ticagrelor Versus Aspirin on Blood Viscosity in Peripheral Artery Disease Patients With Type 2 Diabetes Completed · 13 cited
  12. Phase 4 Clopidogrel and Aspirin Interaction Study-2 Completed · 11 cited
  13. Phase 4 Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease Completed · 10 cited
  14. Phase 4 A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart Completed · 9 cited
  15. Phase 4 Ticagrelor Antiplatelet Therapy to Reduce Graft Events and Thrombosis Completed · 9 cited
  16. Phase 4 Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention Completed · 7 cited
  17. Phase 3 Low Doses of Aspirin in the Prevention of Preeclampsia Completed · 4 cited
  18. Phase 4 Phase 4 Study of Effect of Aspirin on Flushing in Dimethyl Fumarate-Treated Participants With Relapsing-Remitting Multiple Sclerosis Completed
  19. Phase 4 Pharmacogenomics of Antiplatelet Response - II (PARes-II) Completed
  20. Phase 4 Pharmacogenomics of Antiplatelet Response Completed
  21. Phase 4 Pharmacogenomics of Antiplatelet Response - I Completed
  22. Phase 4 DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation Completed
  23. Phase 4 Aspirin for Prevention of Venous Thromboembolism Among Ovarian Cancer Patients Receiving Neoadjuvant Chemotherapy Completed
  24. Phase 4 CES1 Carriers in the PAPI Study Completed
  25. Phase 4 The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin Completed
  26. Phase 4 Aspirin Dosing in Diabetic Patients Completed
  27. Phase 4 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed
  28. Phase 4 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed
  29. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome Completed
  30. Phase 4 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed
  31. Phase 4 Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler Completed
  32. Phase 4 Aspirin Responsiveness in Women at Risk for Cardiac Events Completed
  33. Phase 4 Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty Completed
  34. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Heart Disease Completed
  35. Phase 3 A Study on the Use of Tanakan® for Recovery of Neurological Impairment Following Ischaemic Stroke Completed
  36. Phase 3 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Completed
  37. Phase 3 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Completed
  38. Phase 3 Aspirin in Young Psychotic Patients Completed
  39. Phase 3 A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia Completed
  40. Phase 3 PLATINUM Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions-Pharmacokinetics (PLATINUM PK) Completed
  41. Phase 3 A Study to Compare MPR With MP in Newly Diagnosed Multiple Myeloma Subjects 65 Years Old or Older. Completed
  42. Phase 3 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial Completed
  43. Phase 3 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions Completed
  44. Phase 3 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL) Completed

Showing the 50 most-cited and recently-updated of 101 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response
Neurology RCT
Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response Trial shows tirofiban improves outcomes for some stroke patients
Intravenous tirofiban significantly improves 90-day functional outcomes for acute ischemic stroke patients failing initial tenecteplase ther…
A new clinical trial suggests that adding tirofiban can improve recovery rates for certain types of stroke patients who do not respond well …
JAMA Jun 13, 2026
Apixaban Reduces Intracranial Bleeding Risk Compared To Aspirin In Patients With Cryptogenic Stroke And Atrial Cardiopathy Evidence
Neurology RCT
Apixaban Reduces Intracranial Bleeding Risk Compared To Aspirin In Patients With Cryptogenic Stroke And Atrial Cardiopathy Evidence Trial shows apixaban reduces intracranial bleeding risk versus aspirin in cryptogenic stroke patients
In a multicenter randomized trial of 1,015 patients, apixaban demonstrated a significant reduction in intracranial hemorrhage compared to as…
A trial of 1,015 patients found apixaban caused fewer intracranial hemorrhages than aspirin, offering safety insights for those with cryptog…
Jun 1, 2026
Early dual antiplatelet therapy improves outcomes after ischaemic stroke thrombolysis
Neurology RCT
Early dual antiplatelet therapy improves outcomes after ischaemic stroke thrombolysis Stroke Patients Gain Better Recovery With Early Double Blood Thinner Combo
A Chinese trial found that starting aspirin and ticagrelor within six hours after thrombolysis boosted excellent functional outcomes at 90 d…
Adding a second blood thinner within hours helps more stroke patients regain full function without raising bleeding risks
May 15, 2026
Narrative review suggests precision interventions for preeclampsia phenotypes
Drug Pipeline Sys. Review
Narrative review suggests precision interventions for preeclampsia phenotypes At-a-Glance
This narrative review examines prevention strategies for preeclampsia in pregnant women. The authors note that standard low-dose aspirin eff…
Preeclampsia prevention is moving beyond aspirin for everyone, with new research showing that matching treatments to a woman's specific risk…
Frontiers May 12, 2026
Tailored antiplatelet strategy showed no benefit over standard dual therapy in high-risk PCI patients
Cardiology RCT
Tailored antiplatelet strategy showed no benefit over standard dual therapy in high-risk PCI patients New heart drug plan failed to beat standard care for high-risk patients
This randomized clinical trial compared a tailored antiplatelet strategy involving early low-dose ticagrelor followed by late de-escalation …
Doctors tested a custom heart drug plan but found standard treatment still works best for high-risk patients
May 5, 2026
Meta-analysis finds no stroke benefit but possible bleeding risk with continued OAC after AF ablation
Cardiology Meta-analysis
Meta-analysis finds no stroke benefit but possible bleeding risk with continued OAC after AF ablation Stopping blood thinners after heart rhythm repair does not lower stroke risk
This meta-analysis evaluated six studies involving patients who met conventional guideline thresholds for oral anticoagulation after apparen…
A large review found that stopping blood thinners after heart rhythm repair did not lower stroke risk and might slightly raise bleeding risk…
May 1, 2026
Proof of concept study uses preSCRIPT framework to annotate prescriptions in UK Biobank
Genetics & Precision Medicine
Proof of concept study uses preSCRIPT framework to annotate prescriptions in UK Biobank preSCRIPT framework identifies genetic links to drug response in UK Biobank
This proof of concept study utilized the preSCRIPT framework to filter and annotate raw prescription data from the UK Biobank, which include…
A proof of concept study in the UK Biobank used preSCRIPT to find genetic links to how people respond to common medications like warfarin an…
medRxiv Apr 30, 2026
Network meta-analysis of LMWH and aspirin for high-risk singleton pregnancies with fetal growth restriction
Drug Pipeline Meta-analysis
Network meta-analysis of LMWH and aspirin for high-risk singleton pregnancies with fetal growth restriction New Treatment Cuts Risk of Dangerous Pregnancy Complication
This network meta-analysis evaluated low-molecular-weight heparin (LMWH) and low-dose aspirin (LDA) in singleton pregnancies at high risk of…
Low-dose blood thinners combined with aspirin significantly reduce the risk of dangerous fetal growth restriction in high-risk pregnancies.
Frontiers Apr 19, 2026
Prospective observational study identifies 2,504 potential drug-drug interactions among hospitalized patients with acute coronary syndrome
Drug Pipeline Cohort
Prospective observational study identifies 2,504 potential drug-drug interactions among hospitalized patients with acute coronary syndrome Heart Patients Face Hidden Risks From Common Drug Mixes
This prospective observational cohort study evaluated 371 hospitalized patients with acute coronary syndrome at Assiut University Heart Hosp…
Taking several heart medications at once can create dangerous hidden interactions that increase the risk of treatment failure and hospital s…
Frontiers Apr 19, 2026
Narrative review examines left atrial appendage closure for stroke prevention in atrial fibrillation
Cardiology Sys. Review
Narrative review examines left atrial appendage closure for stroke prevention in atrial fibrillation The Tiny Ear-Shaped Pouch in Your Heart That Could Cause a Stroke
This narrative review evaluates left atrial appendage (LAA) closure as an alternative to warfarin, aspirin, or DOAC therapy for adults with …
A small heart implant seals off a stroke-risk pouch for atrial fibrillation patients who can't safely take blood thinners, with success rate…
Frontiers Apr 18, 2026
VerifyNow-guided antiplatelet modification linked to lower stroke recurrence in atherothrombotic or lacunar infarction
Neurology RCT
VerifyNow-guided antiplatelet modification linked to lower stroke recurrence in atherothrombotic or lacunar infarction Testing Blood Saves Stroke Patients From Recurrence
A retrospective observational study of 243 patients with atherothrombotic or lacunar infarction found that VerifyNow-guided antiplatelet the…
Doctors who adjusted blood thinner choices based on a simple blood test saw far fewer repeat strokes in patients with prior clots.
medRxiv Apr 16, 2026
Cerebral infarction common in tuberculous meningitis and linked to disease severity and arterial occlusion
Neurology RCT
Cerebral infarction common in tuberculous meningitis and linked to disease severity and arterial occlusion Could blood thinners or specific treatments make brain strokes worse in severe meningitis?
This secondary analysis of the ACT-TBM randomized trial examined 226 patients with tuberculous meningitis at two tertiary centers in India.
Patients with tuberculous meningitis and blocked arteries were much more likely to develop strokes, especially if they received modified tub…
Apr 15, 2026

All aspirin Articles