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Home › Conditions › Bronchopulmonary Dysplasia

Bronchopulmonary Dysplasia

Part of EVALI

11 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Bronchopulmonary Dysplasia

24 trials tracked for Bronchopulmonary Dysplasia: 7 in phase 3 or 4 and 3 with published results. The most-cited published study has 110 citations.

24Trials tracked
7Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 1 Phase 3 6 Phase 2 7 Phase 1 2 Other / NA 8
  1. Phase 3 Hydrocortisone for BPD Completed · 110 cited
  2. Phase 3 Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia Completed · 83 cited
  3. Phase 3 Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide Completed · 25 cited
  4. Phase 4 Preterm Infant Inhaled Albuterol Dosing Completed
  5. Phase 3 Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants Completed
  6. Phase 3 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed
Show 18 more trials
  1. Phase 3 Palivizumab for Prevention of Severe Respiratory Syncytial Virus Infection in Russian Children Completed
  2. Phase 2 Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia (BPD) Completed
  3. Phase 2 Safety of Sildenafil in Premature Infants Completed
  4. Phase 2 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants Completed
  5. Phase 2 Efficacy of Recombinant Human Clara Cell 10 Protein (rhCC10) Administered to Premature Neonates With Respiratory Distress Syndrome Completed
  6. Phase 2 Examining the Use of Non-Invasive Inhaled Nitric Oxide to Reduce Chronic Lung Disease in Premature Newborns Completed
  7. Phase 2 Trial II of Lung Protection With Azithromycin in the Preterm Infant Completed
  8. Phase 2 Antibiotic "Dysbiosis" in Preterm Infants Completed
  9. Phase 1 Inhaled Tobramycin in BPD Completed
  10. Phase 1 Enteral L Citrulline Supplementation in Preterm Infants - Safety, Efficacy and Dosing Completed
  11. N/A Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator Completed
  12. N/A Analysis of BPD in Premature Infants With Typical Imaging Changes Completed
  13. N/A BPD Saturation TARgeting Completed
  14. N/A Comparison of Classification Standards of Bronchopulmonary Dysplasia (BPD) in Premature Infants Completed
  15. N/A GER Poses a Potential Risk for Late Complications of BPD Completed
  16. N/A Relationship Between EIT and Respiratory Status in Very Preterm Infants Completed
  17. N/A Effective Approaches & Strategies to Ease Off Nasal CPAP In Preterm Infants Completed
  18. N/A Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants Completed

Showing the 24 most-cited and recently-updated of 24 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Bronchopulmonary Dysplasia: what the trials found

Clinical investigations into the management of Bronchopulmonary Dysplasia (BPD) have evaluated several pharmacological and respiratory interventions. Hydrocortisone administration was assessed for its impact on BPD grading at 36 weeks postmenstrual age, duration of mechanical ventilation, and length of hospital stay; however, no significant differences were observed in these metrics 4. Additionally, hydrocortisone use was associated with significantly different regional brain volumes compared to controls 15.

Surfactant therapies, including Infasurf, were evaluated for their impact on survival without BPD at 36 weeks and 40 weeks postmenstrual age, showing no statistically significant differences between groups [5, 6]. Inhaled Nitric Oxide (iNO) was also studied; while it showed no significant difference in survival without BPD at 36 weeks or the number of days on airway pressure support, it was utilized as a standard intervention in some cohorts 7. Other established interventions include surfactant administration 8 and palivizumab 9.

Recent results — preliminary, needs further review

  • Sildenafil is currently being investigated in Phase 2 trials for BPD 1.
  • The Sentec LuMon Device (EIT system) showed a statistically significant difference in the Global Inhomogeneity Index at 31 weeks postmenstrual age between patients who successfully and unsuccessfully discontinued non-invasive ventilation 18.

For the clinician treating this condition

  • Hydrocortisone does not appear to significantly alter BPD grading or mechanical ventilation duration, though it is associated with differences in regional brain volumes.
  • Surfactant and Inhaled Nitric Oxide (iNO) do not show statistically significant differences in survival without BPD at 36 weeks postmenstrual age based on the provided data.
  • EIT metrics (specifically Global Inhomogeneity Index) may serve as indicators for the success of non-invasive ventilation discontinuation.

AI synthesis of 7 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Echocardiographic Measures Predict Bronchopulmonary Dysplasia in Preterm Infants
Pediatrics Meta-analysis
Echocardiographic Measures Predict Bronchopulmonary Dysplasia in Preterm Infants Heart measurements help predict lung disease in preterm infants
A meta-analysis of 1316 preterm infants found that echocardiographic measures of right heart function significantly predict bronchopulmonary…
Specific heart measurements can help doctors predict if a premature baby will develop a serious lung condition called bronchopulmonary dyspl…
NEJM Jul 26, 2026
Soluble CD146 serves as a marker of microvascular stress and promotes tumor invasion
Oncology Sys. Review
Soluble CD146 serves as a marker of microvascular stress and promotes tumor invasion Soluble CD146 May Help Identify Cancer and Heart Stress
This systematic review examines the role of soluble CD146 (sCD146) in malignant solid tumors and cardiovascular diseases. The authors conclu…
A protein called sCD146 may help doctors identify cancer cell behavior and track stress in heart and lung tissues.
Frontiers Jul 23, 2026
Multimodal lung-protective strategies reduce BPD risk in preterm infants
Pediatrics Sys. Review
Multimodal lung-protective strategies reduce BPD risk in preterm infants New insights into managing lung damage in preterm infants
This narrative review synthesizes evidence on bronchopulmonary dysplasia (BPD) in preterm infants, highlighting its multifactorial pathophys…
Doctors are identifying key risk factors and treatment paths for bronchopulmonary dysplasia to better protect the lungs of premature babies.
Frontiers Jul 22, 2026
Early postnatal antibiotic exposure increases BPD risk in very preterm infants across 11 studies
Pediatrics Meta-analysis
Early postnatal antibiotic exposure increases BPD risk in very preterm infants across 11 studies Early Antibiotic Exposure Linked to Risks for Very Preterm Infants
This meta-analysis of 11 studies indicates that early postnatal antibiotic exposure is associated with an increased risk of bronchopulmonary…
Early antibiotic use in very preterm infants is linked to higher risks of lung issues, intestinal damage, and mortality.
Frontiers Jul 17, 2026
Early hemodynamic phenotyping may improve risk stratification and prevent pulmonary vascular disease in preterm infants
Pediatrics Sys. Review
Early hemodynamic phenotyping may improve risk stratification and prevent pulmonary vascular disease in preterm infants Early signs of lung disease in preterm infants identified early
This narrative review synthesizes experimental, translational, and clinical data regarding pulmonary vascular growth and ventricular functio…
Doctors can now use heart scans and biomarkers to spot early signs of lung and heart issues in premature babies with lung disease.
Frontiers Jun 25, 2026
Vitamin D deficiency increases odds of sepsis and mechanical ventilation in neonates
Pulmonology & Critical Care Meta-analysis
Vitamin D deficiency increases odds of sepsis and mechanical ventilation in neonates Vitamin D Deficiency Linked to Higher Sepsis Risk in Neonates
This meta-analysis of 18 studies involving 1981 patients found that Vitamin D deficiency is associated with a higher risk of sepsis and incr…
Low vitamin D levels are linked to higher rates of sepsis and longer hospital stays for babies in neonatal intensive care units.
Frontiers Jun 16, 2026
High-Dose Vitamin D and Low-Dose Vitamin A May Reduce Bronchopulmonary Dysplasia in Preterm Infants
Pediatrics Meta-analysis
High-Dose Vitamin D and Low-Dose Vitamin A May Reduce Bronchopulmonary Dysplasia in Preterm Infants High-Dose Vitamin D May Reduce BPD in Preterm Infants
A network meta-analysis of 4357 preterm infants found that high-dose vitamin D (≥800 IU/d) most notably reduced bronchopulmonary dysplasia i…
A large analysis of preterm infants found that high-dose vitamin D (≥800 IU/day) may lower the risk of bronchopulmonary dysplasia, while low…
NEJM Jun 4, 2026
LSTM analysis of infant tidal breathing detects bronchopulmonary dysplasia with 97% accuracy
Pulmonology & Critical Care Cohort
LSTM analysis of infant tidal breathing detects bronchopulmonary dysplasia with 97% accuracy New AI tool reads baby breath to spot lung disease early
This cohort study of 329 infants and 135 school-age children used recurrent neural networks to analyze tidal breathing flow time series.
A new computer model can read a baby's simple breathing pattern to find lung disease before it becomes serious.
medRxiv Apr 29, 2026
Narrative review examines high-risk factors and major nursing interventions for bronchopulmonary dysplasia in premature infants
Pediatrics Sys. Review
Narrative review examines high-risk factors and major nursing interventions for bronchopulmonary dysplasia in premature infants Nursing care and risk factors for lung disease in premature babies
This narrative review addresses high-risk factors for bronchopulmonary dysplasia and major nursing interventions in premature infants.
This review looks at how nursing interventions and high-risk factors affect premature infants with bronchopulmonary dysplasia, offering insi…
Frontiers Apr 24, 2026
Closed-loop oxygen control shortens ventilation and oxygen duration in preterm infants in RCT
Pediatrics RCT
Closed-loop oxygen control shortens ventilation and oxygen duration in preterm infants in RCT New Technology Helps Preterm Babies Spend Less Time on Ventilators
This randomized controlled trial in 69 preterm infants compared closed-loop automated oxygen control to manual control.
A smart oxygen system helped preterm babies breathe on their own sooner, cutting ventilator time and reducing lung disease risk.
Apr 19, 2026
Lung ultrasound scores higher in children with moderate-to-severe BPD; abnormal scores may aid readmission risk assessment
Pediatrics Cohort
Lung ultrasound scores higher in children with moderate-to-severe BPD; abnormal scores may aid readmission risk assessment Lung ultrasound scores differ in children with severe bronchopulmonary dysplasia
A cross-sectional cohort study of 125 children aged 0–24 months found higher lung ultrasound scores in those with Grade 2 and 3 bronchopulmo…
A single lung ultrasound can spot breathing trouble risks in children with severe lung disease, though normal scans do not rule out the cond…
Frontiers Apr 5, 2026

Questions about Bronchopulmonary Dysplasia

What nursing interventions are recommended for premature infants at high risk for bronchopulmonary dysplasia?

Nursing care for premature infants at risk of bronchopulmonary dysplasia focuses on precise oxygen control, adequate staffing, and early detection using breathing pattern analysis.

Full answer →
Can breathing patterns detected by AI help diagnose bronchopulmonary dysplasia in infants?

Yes, AI analysis of breathing patterns can help diagnose bronchopulmonary dysplasia in infants, with one study showing 97% accuracy using LSTM networks on tidal breathing data.

Full answer →