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Home › Medications › etanercept

etanercept

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of etanercept

104 trials tracked of etanercept: 59 in phase 3 or 4 and 15 with published results. The most-cited published study has 388 citations.

104Trials tracked
59Phase 3 & 4
0Recruiting
15With published results
Phase distribution
Phase 4 34 Phase 3 25 Phase 2 16 Phase 1 3 Other / NA 26
  1. Phase 3 Etanercept (Enbrel®) in Psoriasis - Pediatrics Completed · 388 cited
  2. Phase 4 A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors Completed · 230 cited
  3. Phase 3 Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis Completed · 216 cited
  4. Phase 3 Efficacy and Safety Study of Certolizumab Pegol (CZP) Versus Active Comparator and Placebo in Subjects With Plaque Psoriasis (PSO) Completed · 130 cited
  5. Phase 3 A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDs Completed · 108 cited
  6. Phase 3 TNF-alpha Antagonists for AECOPD: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial Completed · 102 cited
Show 44 more trials
  1. Phase 3 Effectiveness of Etanercept for Idiopathic Pneumonia Syndrome Following Stem Cell Transplantation (BMT CTN 0403) Completed · 92 cited
  2. Phase 4 Treatments Against RA and Effect on FDG-PET/CT Completed · 73 cited
  3. Phase 3 Extension Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Completed · 46 cited
  4. Phase 3 Study of Ixekizumab (LY2439821) in Children 6 to Less Than 18 Years With Moderate-to-Severe Plaque Psoriasis Completed · 43 cited
  5. Phase 4 Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening Completed · 36 cited
  6. Phase 4 Safety Study Of Tofacitinib Versus Tumor Necrosis Factor (TNF) Inhibitor In Subjects With Rheumatoid Arthritis Completed · 15 cited
  7. Phase 4 Study to Evaluate the Efficacy of Etanercept Treatment in Adults Who Failed Therapy With Apremilast Completed · 7 cited
  8. Phase 4 Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA Completed · 6 cited
  9. Phase 3 Study to Assess the Immunogenicity, Safety, and Efficacy of High Capacity Process Etanercept in Rheumatoid Arthritis Subjects Completed · 1 cited
  10. Phase 4 Study to Assess the Immunogenicity and Safety of Etanercept Produced Using a Modified Process in Patients With Plaque Psoriasis Completed
  11. Phase 4 The Immunological Basis for Treatment Resistance to Anti-TNF Treatments Completed
  12. Phase 4 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Completed
  13. Phase 4 Evaluation of EULAR-RAID Score in Rheumatoid Arthritis Patients Completed
  14. Phase 4 Study Evaluating Etanercept Plus Methotrexate in Early Rheumatoid Arthritis Completed
  15. Phase 4 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed
  16. Phase 4 Anti-TNF Agents for the Treatment of Rheumatoid Arthritis Completed
  17. Phase 4 Study Evaluating Etanercept for the Treatment of Moderate to Severe Psoriasis Completed
  18. Phase 4 Can We Miss Pigmented Lesions in Psoriasis Patients? Completed
  19. Phase 4 Study Evaluating Etanercept in the Treatment of Subjects With Psoriasis Completed
  20. Phase 4 REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®) Completed
  21. Phase 4 Study Comparing Etanercept and Methotrexate vs. Methotrexate Alone in Rheumatoid Arthritis Completed
  22. Phase 4 Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel) Completed
  23. Phase 4 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed
  24. Phase 4 Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA Completed
  25. Phase 4 Effects of Etanercept on Nail Psoriasis and Plaque Psoriasis Completed
  26. Phase 4 Safety and Efficacy of Combining nbUVB to Etanercept in Patients Completed
  27. Phase 4 Moderate to Severe Plaque Psoriasis With Scalp Involvement Completed
  28. Phase 4 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed
  29. Phase 4 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed
  30. Phase 4 CAMEO: Canadian Methotrexate and Etanercept Outcome Study Completed
  31. Phase 4 Study Comparing 2 Different Strategies For Management of Subjects With Plaque Psoriasis Who Have Responded to Etanercept Completed
  32. Phase 4 Treatment of Early Aggressive Rheumatoid Arthritis (TEAR) Completed
  33. Phase 4 Study Evaluating the Efficacy and Safety of Etanercept and Acitretin in Korean Patient With Moderate to Severe Psoriasis Completed
  34. Phase 4 A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis Completed
  35. Phase 4 Study Comparing Etanercept in Combination With Methotrexate in Subjects With Rheumatoid Arthritis Completed
  36. Phase 4 Evaluation of Etanercept in Patients With Plaque Psoriasis After Stopping Ciclosporin Therapy Completed
  37. Phase 4 Canadian Assessment of Patient Outcomes and Effectiveness of Etanercept (Enbrel) in Psoriasis Completed
  38. Phase 3 Pediatric Open-Label Extension Study of Etanercept in Patients With Plaque Psoriasis Completed
  39. Phase 3 Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Chronic Plaque Psoriasis (PsO) Completed
  40. Phase 3 Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA) Completed
  41. Phase 3 Safety and Efficacy of Etanercept (Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein [TNFR:Fc]) in Children With Juvenile Rheumatoid Arthritis (JRA) Completed
  42. Phase 3 Efficacy and Safety of Etanercept 50 mg Once Weekly Plus As Needed Topical Agent in Moderate to Severe Plaque Psoriasis Completed
  43. Phase 3 A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar Pustulosis Completed
  44. Phase 3 Open Label, Dose-Regimen Study Evaluating Etanercept 50 mg Once-Weekly In Japanese Subjects With RA Completed

Showing the 50 most-cited and recently-updated of 104 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Etanercept therapy alters monocyte subsets and improves DAS28-CRP in rheumatoid arthritis patients
Drug Pipeline Cohort
Etanercept therapy alters monocyte subsets and improves DAS28-CRP in rheumatoid arthritis patients High monocyte levels predict better RA drug response
This prospective cohort study evaluated etanercept therapy in rheumatoid arthritis patients over 12 and 24 weeks.
A simple blood test may soon help doctors know which RA patients will respond to a widely used drug — sparing others months of wasted time a…
Frontiers Apr 24, 2026
Subcutaneous etanercept rapidly alleviated pain and inflammation in 12 acute gout patients compared to methylprednisolone
Rheumatology RCT
Subcutaneous etanercept rapidly alleviated pain and inflammation in 12 acute gout patients compared to methylprednisolone Small study finds etanercept may help acute gout pain like steroids
This single-center, prospective, randomized, open-label study evaluated subcutaneous etanercept versus intravenous methylprednisolone in 12 …
A small study found etanercept provided rapid pain relief for acute gout flares that matched standard steroid treatment with no serious side…
Apr 8, 2026