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Home › Medications › fluoxetine

fluoxetine

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of fluoxetine

52 trials tracked of fluoxetine: 24 in phase 3 or 4 and 9 with published results. The most-cited published study has 426 citations.

52Trials tracked
24Phase 3 & 4
0Recruiting
9With published results
Phase distribution
Phase 4 12 Phase 3 12 Phase 2 16 Phase 1 3 Other / NA 9
  1. Phase 4 Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder Completed · 426 cited
  2. Phase 4 Fluoxetine to Prevent Relapse and Enhance Psychological Recovery in Women With Anorexia Nervosa Completed · 391 cited
  3. Phase 4 Improving Sleep and Psychological Functioning in People With Depression and Insomnia Completed · 235 cited
  4. Phase 4 Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder Completed · 120 cited
  5. Phase 3 Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial) Completed · 13 cited
  6. Phase 4 Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging Completed · 8 cited
Show 44 more trials
  1. Phase 4 Identifying and Treating Depression in Hemodialysis Patients Completed · 6 cited
  2. Phase 3 Safety and Efficacy of Levomilnacipran ER in Adolescent Participants With Major Depressive Disorder Completed · 5 cited
  3. Phase 3 Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric Patients (7-17 Years) With Major Depressive Disorder Completed · 5 cited
  4. Phase 4 The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder Completed
  5. Phase 4 Effect of Antidepressants on Sex Hormone Levels and Sexual Functioning Completed
  6. Phase 4 Fluoxetine to Reduce Intubation and Death After COVID19 Infection Completed
  7. Phase 4 Fluoxetine Treatment of Depression in Down Syndrome Completed
  8. Phase 4 A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe Depression Completed
  9. Phase 4 Fluoxetine in Pediatric Body Dysmorphic Disorder Completed
  10. Phase 3 Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms Completed
  11. Phase 3 Safety and Efficacy of Vilazodone in Pediatric Patients With Major Depressive Disorder (VLZ-MD-22) Completed
  12. Phase 3 A Study of Fluoxetine in Major Depressive Disorder (MDD) Long-Term Dosing Completed
  13. Phase 3 A Study in the Treatment of Children and Adolescents With Major Depressive Disorder Completed
  14. Phase 3 A Study of Fluoxetine in Major Depressive Disorder (MDD) Short-Term Dosing Completed
  15. Phase 3 A Study in Relapse Prevention of Treatment-Resistant Depression Completed
  16. Phase 3 A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDD Completed
  17. Phase 3 Safety and Efficacy of Fluoxetine in Juvenile Fibromyalgia Completed
  18. Phase 3 A Study in the Treatment of Children and Adolescents With Major Depressive Disorder Completed
  19. Phase 2 Poststroke Depression in Hemorrhagic Stroke Completed
  20. Phase 2 Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence Completed
  21. Phase 2 An Adaptive Treatment Strategy for Adolescent Depression-Continuation Completed
  22. Phase 2 Characterization and Sequential Pharmacotherapy of Severe Mood Dysregulation Completed
  23. Phase 2 Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI Completed
  24. Phase 2 Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression Completed
  25. Phase 2 An Adaptive Treatment Strategy for Adolescent Depression Completed
  26. Phase 2 Fluoxetine Mitigation Mental Health Study for Patients With Musculoskeletal Trauma Completed
  27. Phase 2 Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial Completed
  28. Phase 2 Early Intervention With Fluoxetine in Autism Completed
  29. Phase 2 Homeopathic Treatment for Depression in Peri- and Postmenopausal Women Completed
  30. Phase 2 A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder Completed
  31. Phase 2 Dichotic Listening as a Predictor of Medication Response in Depression Completed
  32. Phase 2 Effects rTMS Combined With Fluoxetine on Motor Recovery in Stroke Patients Completed
  33. Phase 2 Treatment of Hypochondriasis With CBT and/or SSRI Completed
  34. Phase 2 Safety and Efficacy of Fluoxetine in Pulmonary Arterial Hypertension Completed
  35. Phase 1 90 mg Fluoxetine Hydrochloride Capsules Under Non-Fasting Conditions Completed
  36. Phase 1 90 mg Fluoxetine Hydrochloride Capsules Under Fasting Conditions Completed
  37. Phase 1 A Study to Measure if There is Any Difference in How the Body Breaks Down or Inactivates Either Fluoxetine or LY2216684 When Both of These Medicines Are Given Together. Completed
  38. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Completed
  39. N/A Impact of GABA-Enhancing Agents on Cortical GABA Concentrations Across the Menstrual Cycle in Women Completed
  40. N/A Efficacy of Fluoxetine in Reducing Ictal Hypoventilation in Patients With Partial Epilepsy Completed
  41. N/A SMART-DAPPER: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research Project Completed
  42. N/A Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea Completed
  43. N/A Brain Imaging Techniques That Predict Antidepressant Responsiveness Completed
  44. N/A Sequential Treatment of Pediatric MDD to Increase Remission and Prevent Relapse Completed

Showing the 50 most-cited and recently-updated of 52 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Fluoxetine Linked to Small but Significant Blood Pressure Rise
Cardiology Meta-analysis
Fluoxetine Linked to Small but Significant Blood Pressure Rise Fluoxetine linked to small rise in blood pressure
A meta-analysis of 538 participants found fluoxetine associated with modest increases in systolic and diastolic blood pressure versus placeb…
A review of trials finds fluoxetine may raise blood pressure slightly, a finding that warrants caution for people taking the antidepressant.
Frontiers May 28, 2026
Pilot study of fluoxetine and calcium in musculoskeletal trauma victims showed no measurable benefit
Emergency Medicine Phase II
Pilot study of fluoxetine and calcium in musculoskeletal trauma victims showed no measurable benefit A Common Antidepressant May Ease Recovery After Serious Injuries
This pragmatic pilot study evaluated fluoxetine and calcium in 68 victims of musculoskeletal trauma.
A common low-dose antidepressant may help adults recover emotionally after serious bone and joint injuries, addressing the hidden mental tol…
CT.gov Apr 16, 2026