CAR T-cell therapy targeting CD19 or BCMA may induce sustained remission in specific autoimmune diseases
CAR T-cell Therapy Shows Potential for Autoimmune Disease Remission
This systematic review examines CAR T-cell therapies for patients with systemic lupus erythematosus, idiopathic inflammatory myopathy, and s…
A new type of cell therapy may offer a way to reset the immune system in patients with lupus, scleroderma, and inflammatory myopathy.
Glucocorticoid signaling and stress-related neuroendocrine dysregulation influence intraocular pressure and inflammatory pathways in ocular diseases
Stress and hormones may play a role in eye health
This narrative literature overview of 35 studies synthesizes the role of glucocorticoid signaling and stress-related neuroendocrine dysregul…
New research suggests that stress-related hormone changes could influence conditions like glaucoma and other serious eye diseases.
Glucocorticoid use and rheumatoid arthritis significantly increase vertebral fracture risk in postmenopausal women
Several risk factors increase fracture risk for women with osteoporosis
This meta-analysis of 11 studies involving 7,605 participants identifies several risk factors for vertebral fractures in postmenopausal wome…
Women with rheumatoid arthritis or those using certain medications face a much higher risk of spine fractures.
Mycophenolate mofetil combined with conventional therapy offers best balance of efficacy and safety
Different medications show different benefits for children with kidney inflammation
This network meta-analysis evaluates immunosuppressive regimens for Chinese children with Henoch-Schönlein purpura nephritis. The analysis i…
New data helps doctors choose the best medication combinations to treat kidney inflammation in children with IgA vasculitis.
Triple consolidation with CAR T cells yields sustained remission in relapsed BPDCN
New treatment strategy shows promise for rare blood cancer
This case report and literature review describes a 55-year-old man with relapsed/refractory BPDCN and CNS involvement who achieved sustained…
A new three-part treatment plan helped a man with a rare, aggressive blood cancer achieve long-term remission when no donor was available.
Metagenomic sequencing identifies Rickettsia felis encephalitis in a child who fully recovered
Rare Cat Flea Bacteria Causes Encephalitis in Child
This case report and literature review describes a 9-year-old boy with R. felis encephalitis diagnosed via metagenomic next-generation seque…
A 9-year-old boy's severe brain infection was caused by a rare cat flea bacteria, not a virus. He recovered after targeted treatment.
Sintilimab may trigger autoimmune GFAP astrocytopathy in esophageal squamous cell carcinoma patients
New cancer treatment may cause rare brain inflammation in patients
This case report and literature review describes a patient with advanced esophageal squamous cell carcinoma who developed autoimmune GFAP as…
A new type of immunotherapy for esophageal cancer can trigger a rare brain condition, requiring doctors to watch for early signs of neurolog…
Evaluating Treat to Target Outcomes in Elderly and Young Rheumatoid Arthritis Patients
Treat-to-Target Strategy Shows Promise for Elderly Rheumatoid Arthritis
A multicenter trial confirms that elderly patients achieve similar clinical outcomes and safety profiles as younger cohorts under a standard…
A new study shows that elderly patients with rheumatoid arthritis can achieve similar results to younger patients using a standard treat-to-…
Anatomical and immunological factors drive pathogenesis in plasma cell mastitis cases
New insights into the causes and treatment of mastitis
This narrative review synthesizes the etiology, clinical manifestations, and treatment strategies for plasma cell mastitis. It highlights ho…
Doctors are identifying how structural issues and immune responses lead to chronic inflammation in breast tissue, helping clarify treatment …
Ianalumab plus eltrombopag extends time to treatment failure in primary ITP adults
Study tests ianalumab plus eltrombopag for adults with immune thrombocytopenia
This phase 3 randomized, double-blind trial in 152 adults with primary ITP and insufficient response to glucocorticoids found that ianalumab…
Adding ianalumab to standard therapy helped more adults with immune thrombocytopenia stay stable and avoid treatment failure compared to pla…
Drug-induced osteoporosis mechanisms and gut microbiota links remain largely unresolved for most medication classes
Many common medicines might change gut bacteria and affect bone strength in older adults
This narrative review examines the association between medications such as glucocorticoids and aromatase inhibitors and gut microbiota alter…
Some drugs like antidepressants and seizure medicines can alter gut bacteria. Scientists are still studying if these changes hurt bones or c…
ERAS protocols may reduce opioid use and shorten stays for patients undergoing orthognathic surgery
ERAS protocols show promise for orthognathic surgery recovery
This narrative review examines the application of Enhanced Recovery After Surgery (ERAS) protocols in orthognathic surgery. The authors synt…
Enhanced Recovery After Surgery protocols may reduce opioid use and shorten hospital stays for patients undergoing jaw surgery.