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Home › Medications › hydrochlorothiazide

hydrochlorothiazide

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of hydrochlorothiazide

49 trials tracked of hydrochlorothiazide: 35 in phase 3 or 4 and 6 with published results. The most-cited published study has 151 citations.

49Trials tracked
35Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 20 Phase 3 15 Phase 2 4 Phase 1 5 Other / NA 5
  1. Phase 3 Diuretic Comparison Project Completed · 151 cited
  2. Phase 4 Nephropathy In Type 2 Diabetes and Cardio-renal Events Completed · 133 cited
  3. Phase 4 Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension Completed · 12 cited
  4. Phase 3 A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension Completed · 11 cited
  5. Phase 4 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Completed · 9 cited
  6. Phase 4 N-of-1 Trials In Children With Hypertension Completed · 9 cited
Show 43 more trials
  1. Phase 4 Salt Loading and Thiazide Intervention Study Completed
  2. Phase 4 Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide Completed
  3. Phase 4 INTERVENCION Trial Completed
  4. Phase 4 Telmisartan 80mg Plus Hydrochlorothiazide 25mg First Line in Moderate or Severe Hypertension Completed
  5. Phase 4 Efficacy and Safety of Valsartan Versus Amlodipine in Postmenopausal Women With Hypertension Completed
  6. Phase 4 Pharmacogenomic Evaluation of Antihypertensive Responses Completed
  7. Phase 4 Effect of Licorice and Hydrochlorothiazide on Plasma Potassium Completed
  8. Phase 4 Black Education and Treatment of Hypertension (BEAT HTN) Completed
  9. Phase 4 Blood Pressure Lowering of Aliskiren HCTZ Compared to HCTZ in Stage 2 Systolic Hypertension in Older Population Completed
  10. Phase 4 Efficacy and Tolerability of an Aliskiren-based Treatment Algorithm in Patients With Mild to Moderate Hypertension Completed
  11. Phase 4 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics Completed
  12. Phase 4 ALiskiren or Losartan Effects on bioMARKers of Myocardial Remodeling Completed
  13. Phase 4 Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study) Completed
  14. Phase 4 Candesartan Effect in Second Stage Arterial Hypertension Completed
  15. Phase 4 Aliskiren HCTZ Compared to Amlodipine in Patients With Stage 2 Systolic Hypertension and Diabetes Mellitus Completed
  16. Phase 4 Aliskiren Plus HCTZ Compared to Aliskiren in Metabolic Syndrome Patients With Stage 2 Systolic Hypertension Completed
  17. Phase 3 Safety and Tolerability of Valsartan in Children 6 to 17 Years of Age Completed
  18. Phase 3 Add-on to Micamlo BP Trial Completed
  19. Phase 3 A Study to Investigate the Magnitude and Duration of Response of MK0954 Compared to Placebo in Patients With Hypertension (0954-021)(COMPLETED) Completed
  20. Phase 3 Aliskiren and the Calcium Channel Blocker Amlodipine Combination as an Initial Treatment Strategy for Hypertension Completed
  21. Phase 3 Antihypertensive Efficacy and Safety of Candesartan/HCT 32/25 mg in Comparison With Individual Components and Placebo Completed
  22. Phase 3 Efficacy and Safety of Valsartan and Amlodipine (± HCTZ) in Adults With Moderate, Inadequately Controlled Hypertension Completed
  23. Phase 3 Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy Completed
  24. Phase 3 An Assessment of Long Term Safety of the Combination of Aliskiren / Amlodipine in Patients With High Blood Pressure Completed
  25. Phase 3 Efficacy and Safety of Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Moderate-severe Hypertension Completed
  26. Phase 3 A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the Elderly Completed
  27. Phase 3 Safety and Efficacy Study of a Triple Combination Therapy in Subjects With Hypertension Completed
  28. Phase 3 A Safety and Tolerability Study of the Combination of Aliskiren/Valsartan in Patients With High Blood Pressure, Followed by Long-term Safety and Tolerability of Aliskiren, Valsartan and Hydrochlorothiazide. Completed
  29. Phase 3 Safety and Efficacy of Valsartan vs Atenolol and Hydrochlorothiazide Combination on Blood Flow in Hypertensive Patients Completed
  30. Phase 2 The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial Completed
  31. Phase 2 Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension Completed
  32. Phase 2 A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential Hypertension Completed
  33. Phase 2 Effects of Dapagliflozin on Kidney Function (Glomerular Filtration Rate) in Subjects With Type 2 Diabetes Completed
  34. Phase 1 A Study of MK-7145 Compared to Placebo and Hydrochlorothiazide for Lowering Blood Pressure in Male Participants With Hypertension (MK-7145-009) Completed
  35. Phase 1 Pharmacodynamics and Pharmacokinetics of Empagliflozin and Torasemide in Patients With Type 2 Diabetes Completed
  36. Phase 1 Bioequivalence of Losartan and Hydrochlorothiazide (HCTZ) Combination Tablet and Coadministration of Its Components (0954A-306) Completed
  37. Phase 1 Aldosterone and the Metabolic Syndrome Completed
  38. Phase 1 Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed) Completed
  39. N/A A Translational Approach to Gitelman Syndrome Completed
  40. N/A Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension Completed
  41. N/A Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease Completed
  42. N/A A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension Completed
  43. N/A Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide Completed

Showing the 49 most-cited and recently-updated of 49 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Lithium-associated nephrogenic diabetes insipidus may cause severe postoperative hypernatremia and polyuria
Nephrology Sys. Review
Lithium-associated nephrogenic diabetes insipidus may cause severe postoperative hypernatremia and polyuria Lithium use may cause kidney issues after surgery in patients
This case report describes a patient with schizophrenia and type 2 diabetes who developed severe hypernatremia and polyuria following a panc…
A man with schizophrenia and diabetes faced severe complications after surgery, highlighting how lithium can affect kidney function and flui…
Frontiers Aug 28, 2026
Amiloride and hydrochlorothiazide affect metabolites and ammonium excretion in CKD patients
Nephrology RCT
Amiloride and hydrochlorothiazide affect metabolites and ammonium excretion in CKD patients Distal diuretics change kidney chemistry in people with chronic kidney disease
This randomized controlled trial in 26 individuals with chronic kidney disease found that distal diuretics decreased plasma glutamine and tr…
A small trial found that taking amiloride and hydrochlorothiazide lowered glutamine and changed how the body handles waste in people with ch…
May 1, 2026