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Home › Medications › ibuprofen

ibuprofen

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of ibuprofen

77 trials tracked of ibuprofen: 41 in phase 3 or 4 and 14 with published results. The most-cited published study has 92 citations.

77Trials tracked
41Phase 3 & 4
0Recruiting
14With published results
Phase distribution
Phase 4 21 Phase 3 20 Phase 2 19 Phase 1 4 Other / NA 13
  1. Phase 3 Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS) Completed · 92 cited
  2. Phase 3 Acetaminophen Versus Ibuprofen in Children With Asthma Completed · 80 cited
  3. Phase 4 Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients Completed · 77 cited
  4. Phase 3 Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain Completed · 65 cited
  5. Phase 3 Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances Completed · 59 cited
  6. Phase 3 Maxigesic 325 Acute Dental Pain Study Completed · 39 cited
Show 44 more trials
  1. Phase 4 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed · 38 cited
  2. Phase 3 Study of Ibuprofen Effects on Brain Function Completed · 34 cited
  3. Phase 4 Evaluation of Oral Midazolam in First-trimester Surgical Abortions Completed · 26 cited
  4. Phase 4 Hydrocodone For Pain Control in First Trimester Surgical Abortion Completed · 25 cited
  5. Phase 4 Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment Completed · 24 cited
  6. Phase 3 Safety, Efficacy, and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients Completed · 24 cited
  7. Phase 4 Pilot Study to Collect and Evaluate Data on the Use of IV* Ibuprofen in the Treatment of an Acute Migraine Attack Completed · 10 cited
  8. Phase 4 Safety and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients Completed · 7 cited
  9. Phase 4 Effect IV Ibuprofen and Inflammatory Responses Completed
  10. Phase 4 The Effect of NSAID Use in the Acute Phase of Skeletally Immature Bone Healing: A Prospective Study Completed
  11. Phase 4 Pre-emptive Analgesics in Orthodontic Treatment Completed
  12. Phase 4 TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy Completed
  13. Phase 4 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed
  14. Phase 4 Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section Completed
  15. Phase 4 A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain. Completed
  16. Phase 4 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Completed
  17. Phase 4 Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain Management Completed
  18. Phase 4 Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures Completed
  19. Phase 4 Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics Completed
  20. Phase 4 Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever Completed
  21. Phase 4 Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13® Completed
  22. Phase 4 Pain Control In First Trimester Medical Abortion: A Randomized Trial Completed
  23. Phase 3 A Study to Assess the Efficacy and Tolerability of Diclofenac Potassium Soft Gelatin Capsules Compared With Ibuprofen Tablets in Patients With Moderate to Severe Postoperative Dental Pain Completed
  24. Phase 3 A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine Completed
  25. Phase 3 Ibuprofen/Caffeine Lower Back or Neck Pain Study Completed
  26. Phase 3 Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy Completed
  27. Phase 3 Patient Narcotic Requirements After Outpatient Otolaryngology Procedures Completed
  28. Phase 3 Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen Completed
  29. Phase 3 Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department Completed
  30. Phase 3 Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers Completed
  31. Phase 3 Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment Completed
  32. Phase 3 Patient Experience Study of Deoxycholic Acid Injection Completed
  33. Phase 3 Study to Assess the Safety and Efficacy of Etoricoxib Versus Ibuprofen in the Treatment of Dysmenorrhea (MK-0663-145 AM1) Completed
  34. Phase 3 Ibuprofen Sodium Tension Headache Study Completed
  35. Phase 3 Double-Blind Follow-on Safety Study of HZT-501 (Ibuprofen 800 mg/Famotidine 26.6 mg) in Subjects Who Have Completed Participation in HZ-CA-301 (NCT00450658) or HZ-CA-303 (NCT00450216) Completed
  36. Phase 2 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Completed
  37. Phase 2 The Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients Completed
  38. Phase 2 Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study) Completed
  39. Phase 2 IBUPAP Study for Pain Management in Children Completed
  40. Phase 2 A Study to Test the Safety and Effectiveness of MK-0974 (Telcagepant) Co-administered With Ibuprofen or Acetaminophen in Patients With Migraines With or Without Aura (MK-0974-046) Completed
  41. Phase 2 Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON). Completed
  42. Phase 2 Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer Completed
  43. Phase 2 Ibuprofen Versus Acetaminophen vs Their Combination in the Relief of Musculoskeletal Pain in the Emergency Setting Completed
  44. Phase 2 Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa... Completed

Showing the 50 most-cited and recently-updated of 77 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
FDA Approves Children's Advil (ibuprofen) for Fever and Minor Aches in Children
Pediatrics FDA Approval
FDA Approves Children's Advil (ibuprofen) for Fever and Minor Aches in Children FDA approves Children's Advil for fever and pain in kids ages 2 and up.
The FDA approved Children's Advil (ibuprofen) for temporary reduction of fever and relief of minor aches and pains due to common cold, flu, …
The FDA approved Children's Advil (ibuprofen) for over-the-counter use in children as young as 2 years to reduce fever and relieve minor ach…
FDA May 6, 2026
FDA Approves Children's Advil (ibuprofen) for Fever and Minor Aches in Children
Pediatrics FDA Approval
FDA Approves Children's Advil (ibuprofen) for Fever and Minor Aches in Children FDA approves Children's Advil for fever and pain relief in kids.
The FDA approved Children's Advil (ibuprofen) oral suspension for temporary fever reduction and relief of minor aches and pains due to commo…
The FDA has approved Children's Advil (ibuprofen) for over-the-counter use in children to reduce fever and relieve minor aches and pains. It…
FDA May 6, 2026
Phase 2 RCT of exercise plus ibuprofen for cancer-related cognitive impairment shows mixed cognitive outcomes
Oncology RCT
Phase 2 RCT of exercise plus ibuprofen for cancer-related cognitive impairment shows mixed cognitive outcomes Exercise and Common Pain Reliever May Sharpen Thinking During Chemo
This phase 2 randomized controlled trial enrolled 86 patients with cancer receiving chemotherapy reporting cognitive problems.
You’re in the middle of chemotherapy. You love your family, your work, your life.
Apr 23, 2026
Paracetamol or ibuprofen treatment outcomes in preterm infants with patent ductus arteriosus: a retrospective cohort analysis
Pediatrics Cohort
Paracetamol or ibuprofen treatment outcomes in preterm infants with patent ductus arteriosus: a retrospective cohort analysis Tiny Hearts, Big Risk: New Clues to a Common Preemie Problem
This retrospective cohort study evaluated pharmacological treatment with intravenous paracetamol or ibuprofen in 60 preterm infants with pat…
For the tiniest premature babies, an open heart passage that doesn't close can be life-threatening, but early treatment helps most infants r…
medRxiv Apr 18, 2026