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Home › Conditions › Sore throat

Sore throat

Part of Pharyngitis

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sore throat

7 trials tracked for Sore throat: 5 in phase 3 or 4 and 1 with published results. The most-cited published study has 15 citations.

7Trials tracked
5Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 3 4 Phase 2 1 Other / NA 1
  1. Phase 3 Placebo-Controlled Onset-of-Action Study of Flurbiprofen Utilizing the Double-Stopwatch Method Completed · 15 cited
  2. Phase 4 Post Operative Sore Throat and Dexamethasone Completed
  3. Phase 3 Clinical Study for Comparative Assessment of Efficacy and Safety of Angal S, Topical Spray and ANTI-ANGIN® FORMULA, Topical Metered Spray in Treatment of Patients With Uncomplicated Acute Infectious and Inflammatory Diseases of the Pharynx, Accompanied by a Sore Throat Completed
  4. Phase 3 A Local Clinical Study for the Comparative Evaluation of Efficacy and Safety of Angal, Lozenges [Menthol] and ANTI-ANGIN® FORMULA, Lozenges, in Treatment of Patients With a Sore Throat Completed
  5. Phase 3 Safety Study of IV Peramivir in Hospitalized Subjects With Confirmed or Suspected Influenza Completed
  6. Phase 2 Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN) Completed
Show 1 more trials
  1. N/A No Post Intubation Laryngeal Symptoms Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Sore throat: what the trials found

Pharmacological and topical interventions have demonstrated efficacy in managing sore throat symptoms. Flurbiprofen was associated with a reduction in the Sore Throat Scale (STS) across multiple timepoints, with 78.2% to 97.0% of participants reporting perceived or meaningful pain relief 2.

Menthol-based formulations provided significant improvements in tonsillopharyngitis severity. Angal lozenges resulted in a 50% reduction in TSS scores for over 97% of participants 3, while Angal S topical spray demonstrated a 96.49% to 98.26% rate of $\geq$50% TSS score reduction (p=0.446) and significant improvements in the percentage of patients without sore throat based on TSS scores 4. Additionally, Peramivir was shown to reduce influenza virus titers by -1.66 to -1.47 at 48 hours 5.

Recent results — preliminary, needs further review

  • ["EndoClip" significantly reduced sore throat scores (p=0.03) and improved difficulty swallowing (p=0.007) in a study of 100 participants 7].

For the clinician treating this condition

  • Flurbiprofen is effective for reducing sore throat scale scores and providing perceived pain relief.
  • Menthol-based lozenges and topical sprays are associated with high rates of significant reduction in tonsillopharyngitis severity scores.
  • EndoClip has shown statistically significant improvements in both sore throat intensity and swallowing difficulty.

AI synthesis of 5 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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