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Home › Medications › leuprolide

leuprolide

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of leuprolide

53 trials tracked of leuprolide: 13 in phase 3 or 4 and 8 with published results. The most-cited published study has 431 citations.

53Trials tracked
13Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 6 Phase 3 7 Phase 2 34 Phase 1 1 Other / NA 5
  1. Phase 3 A Study to Evaluate the Safety and Efficacy of Relugolix in Men With Advanced Prostate Cancer Completed · 431 cited
  2. Phase 4 Impact of Hot Flashes on Sleep and Mood Disturbance Completed · 77 cited
  3. Phase 3 Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With HR+ HER2- aBC Completed · 35 cited
  4. Phase 4 Understanding Experimentally Induced Hot Flushes Completed · 28 cited
  5. Phase 3 A Study of Degarelix in Patients With Prostate Cancer Completed · 25 cited
  6. Phase 4 Regulation of Cervical Mucus Secretion Completed · 12 cited
Show 44 more trials
  1. Phase 4 A Study of ELIGARD® in Hormone-dependent Prostate Cancer Patients Completed · 9 cited
  2. Phase 3 Prevention of Obesity in Women Via Estradiol Regulation Completed · 6 cited
  3. Phase 4 Randomized Crossover Trial to Assess the Tolerability of Gonadotropin Releasing Hormone (GnRH) Analogue Administration Completed
  4. Phase 4 Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS) Completed
  5. Phase 3 Safety, Efficacy, and Pharmacokinetic Behavior of Leuprolide Mesylate in Subjects With Advanced Prostate Carcinoma Completed
  6. Phase 3 Safety, Efficacy, and Pharmacokinetic Behavior of Leuprolide Mesylate (LMIS 25 mg) in Subjects With Prostate Cancer Completed
  7. Phase 3 Thalidomide for the Treatment of Hormone-Dependent Prostate Cancer Completed
  8. Phase 2 Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow Transplantation Completed
  9. Phase 2 Docetaxel, Androgen Ablation, and External-Beam Radiation Therapy in Patients With High-Risk Localized Prostate Cancer Completed
  10. Phase 2 The Role of Hormones in Postpartum Mood Disorders Completed
  11. Phase 2 Systemic and Tumor-Directed Therapy for Oligometastatic Prostate Cancer Completed
  12. Phase 2 A Study of Definitive Therapy to Treat Prostate Cancer Completed
  13. Phase 2 Melanoma Vaccine With Peptides and Leuprolide Completed
  14. Phase 2 AASUR in High Risk Prostate Cancer Completed
  15. Phase 2 Pembrolizumab +/- SD-101 in Hormone-Naïve Oligometastatic Prostate Cancer With RT and iADT Completed
  16. Phase 2 Neoadjuvant Ipilimumab in Prostate Cancer Completed
  17. Phase 2 Hormone Ablation Therapy, Doxorubicin, and Zoledronate With or Without Strontium 89 in Treating Patients With Androgen-Dependent Prostate Cancer and Bone Metastases Completed
  18. Phase 2 Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progressed on or After Prior Treatments Completed
  19. Phase 2 Pazopanib Hydrochloride After Leuprolide Acetate or Goserelin Acetate in Treating Patients With Relapsed Prostate Cancer Completed
  20. Phase 2 S0032, Combination Chemotherapy Plus Hormone Therapy in Treating Patients With Metastatic Prostate Cancer Completed
  21. Phase 2 LHRH Analogue Therapy With Enzalutamide or Bicalutamide in Treating Patients With Hormone Sensitive Prostate Cancer Completed
  22. Phase 2 Neurobiology of Bulimia Nervosa Completed
  23. Phase 2 Abiraterone Prednisone and Hormonal Therapy Before and During Radiation Therapy in Localized Prostate Cancer Completed
  24. Phase 2 Effects of IAS in Men With Localized Biochemical Relapsed Prostate Cancer Completed
  25. Phase 2 Androgen Deprivation Therapy and Vorinostat Followed by Radical Prostatectomy in Treating Patients With Localized Prostate Cancer Completed
  26. Phase 2 Sequencing of Sipuleucel-T and ADT in Men With Non-metastatic Prostate Cancer Completed
  27. Phase 2 Enzalutamide/Leuprolide +/- Abiraterone/Pred in Prostate Completed
  28. Phase 2 Hormonal Ablation, Imatinib Mesylate and Docetaxel for Patients With Prostate Cancer Completed
  29. Phase 2 Enzalutamide and Hormone Therapy Before, During, and After Radiation for High Risk Localized Prostate Cancer Completed
  30. Phase 2 Enzalutamide Versus Standard Androgen Deprivation Therapy for the Treatment Hormone Sensitive Prostate Cancer Completed
  31. Phase 2 Phase II Study of Subcutaneous Injection Depot of Leuprolide Acetate in Patient With Prostate Cancer Completed
  32. Phase 2 Bipolar Androgen-based Therapy for Prostate Cancer (BAT) Completed
  33. Phase 2 Study of Enzalutamide (Formerly MDV3100) as a Neoadjuvant Therapy for Patients Undergoing Prostatectomy for Localized Prostate Cancer Completed
  34. Phase 2 Apalutamide and Leuprolide in Intermediate and High-risk Prostate Cancer Completed
  35. Phase 2 Neoadjuvant And Adjuvant Abiraterone Acetate + Apalutamide Prostate Cancer Undergoing Prostatectomy Completed
  36. Phase 2 Extended Endocrine Therapy for Premenopausal Women With Breast Cancer Completed
  37. Phase 2 GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients Completed
  38. Phase 2 A Study of Definitive Therapy to Treat Prostate Cancer After Prostatectomy Completed
  39. Phase 2 Bicalutamide and Goserelin or Leuprolide Acetate With or Without Cixutumumab in Treating Patients With Newly Diagnosed Metastatic Prostate Cancer Completed
  40. Phase 2 Hormone Therapy and Ipilimumab in Treating Patients With Advanced Prostate Cancer Completed
  41. Phase 2 A Phase 2 Study to Evaluate Safety and Efficacy of Abiraterone Acetate in Male Participants With Prostate Cancer Completed
  42. Phase 1 A Treatment Study for Premenstrual Syndrome (PMS) Completed
  43. N/A GnRH-a and Pregnancy Rate in In Vitro Fertilization (IVF) Cycles. Completed
  44. N/A Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women Completed

Showing the 50 most-cited and recently-updated of 53 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Leuprolide acetate associated with final adult height exceeding mid-parental height in girls with central precocious puberty
Pediatrics Cohort
Leuprolide acetate associated with final adult height exceeding mid-parental height in girls with central precocious puberty More Than Half of Girls on Puberty Therapy Beat Their Genetic Height Potential
This retrospective cohort study included 73 girls with central precocious puberty or early puberty treated with depot leuprolide acetate.
More than half of girls treated for early puberty ended up taller than their genetic prediction, with younger age at treatment being the key…
Frontiers Apr 28, 2026
Enzalutamide Monotherapy Shows Higher Survival and Metastasis-Free Rates Versus Leuprolide in High-Risk Biochemical Recurrence
Drug Pipeline RCT
Enzalutamide Monotherapy Shows Higher Survival and Metastasis-Free Rates Versus Leuprolide in High-Risk Biochemical Recurrence Enzalutamide shows better outcomes than leuprolide for high risk prostate cancer recurrence
This Phase 3 randomized controlled trial evaluated enzalutamide monotherapy versus leuprolide alone in patients with high-risk biochemical r…
Men with high-risk prostate cancer recurrence lived longer and spread less cancer when taking enzalutamide alone instead of leuprolide alone…
Apr 19, 2026