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Home › Conditions › Central precocious puberty

Central precocious puberty

Part of Precocious Puberty

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Central precocious puberty

8 trials tracked for Central precocious puberty: 7 in phase 3 or 4 and 4 with published results. The most-cited published study has 60 citations.

8Trials tracked
7Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 2 Phase 3 5 Other / NA 1
  1. Phase 3 Histrelin Subcutaneous Implant in Children With Central Precocious Puberty Completed · 60 cited
  2. Phase 3 Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious Puberty Completed · 35 cited
  3. Phase 3 A Study to Assess the Efficacy and Safety of the Triptorelin 6-month Formulation in Paediatric Participants With Central Precocious Puberty. Completed · 5 cited
  4. Phase 4 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese Participants Completed · 4 cited
  5. Phase 4 A Study of Leuprolide Acetate Depot in Children With Central Precocious Puberty Completed
  6. Phase 3 Efficacy and Safety Study of Triptorelin 3-Month Formulation in Chinese Children With Central Precocious Puberty. Completed
Show 2 more trials
  1. Phase 3 Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty Completed
  2. N/A A Study to Assess the Safety and Efficacy of Enantone (Leuprorelin) in Central Precocious Puberty (CPP) Among Chinese Participants Completed

Showing the 8 most-cited and recently-updated of 8 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Leuprolide acetate associated with final adult height exceeding mid-parental height in girls with central precocious puberty
Pediatrics Cohort
Leuprolide acetate associated with final adult height exceeding mid-parental height in girls with central precocious puberty More Than Half of Girls on Puberty Therapy Beat Their Genetic Height Potential
This retrospective cohort study included 73 girls with central precocious puberty or early puberty treated with depot leuprolide acetate.
More than half of girls treated for early puberty ended up taller than their genetic prediction, with younger age at treatment being the key…
Frontiers Apr 28, 2026
Quarterly triptorelin showed comparable hormonal suppression to monthly dosing in Chinese girls with central precocious puberty
Pediatrics Cohort
Quarterly triptorelin showed comparable hormonal suppression to monthly dosing in Chinese girls with central precocious puberty Less Frequent Injections Work Just as Well for Girls With Early Puberty
This retrospective cohort study evaluated 70 Chinese girls with central precocious puberty treated at Fuzhou First General Hospital.
Girls with early puberty treated with quarterly injections achieved the same growth protection as monthly shots in a new study.
Frontiers Apr 18, 2026
GnRHa treatment in familial hCG syndrome associated with concurrent beta-hCG elevation in blood and CSF
Diabetes & Endocrinology Sys. Review
GnRHa treatment in familial hCG syndrome associated with concurrent beta-hCG elevation in blood and CSF When a Pregnancy Hormone Shows Up in a Child — and It Is Not Cancer
This case report describes an 8-year-old girl with central precocious puberty treated with a gonadotropin-releasing hormone agonist (GnRHa).
An inherited condition can mimic a brain tumor in children by raising pregnancy hormones, leading to unnecessary surgery and chemotherapy be…
Frontiers Apr 14, 2026

Research across Precocious Puberty

Related studies from across the Precocious Puberty family.

Meta-analysis links postnatal BPA exposure to increased odds of early pubertal onset in children
Pediatrics Meta-analysis
Meta-analysis links postnatal BPA exposure to increased odds of early pubertal onset in children Study finds link between BPA exposure and earlier puberty in girls
A systematic review and meta-analysis of 5,549 predominantly female children found higher postnatal BPA exposure was observationally associa…
Higher exposure to the plastic chemical BPA is linked to earlier puberty in girls, though this review cannot prove it causes the change.
Frontiers Apr 2, 2026

Questions about Central precocious puberty

Is there a link between central precocious puberty treatment and high beta-hCG levels in blood?

Treatment for central precocious puberty does not cause high beta-hCG levels; however, some rare genetic conditions can cause both central precocious puberty and high beta-hCG in the blood simultaneously.

Full answer →
Can leuprolide acetate help girls with central precocious puberty grow taller than their parents?

Research shows that girls with central precocious puberty treated with leuprolide acetate often reach a final adult height greater than their mid-parental height, meaning they can grow taller than their parents.

Full answer →