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Home › Medications › n-acetylcysteine

n-acetylcysteine

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of n-acetylcysteine

39 trials tracked of n-acetylcysteine: 6 in phase 3 or 4 and 2 with published results. The most-cited published study has 504 citations.

39Trials tracked
6Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 4 Phase 2 27 Phase 1 4 Other / NA 2
  1. Phase 3 Prevention of Serious Adverse Events Following Angiography Completed · 504 cited
  2. Phase 3 Achieving Cannabis Cessation-Evaluating N-Acetylcysteine Treatment Completed · 156 cited
  3. Phase 4 Effects of N-acetylcysteine on Cardiorespiratory Control in COPD Patients With Mild-to-moderate Airflow Obstruction Completed
  4. Phase 4 Effects of N-acetylcysteine on Low T3 Syndrome Completed
  5. Phase 3 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed
  6. Phase 3 A Safety and Efficacy Study of NAC in Patients With TA-TMA Completed
Show 33 more trials
  1. Phase 2 Neurocircuit Strategy to Decrease Cocaine Cue Reactivity Completed
  2. Phase 2 N-Acetyl-Cysteine (NAC) in Early Phase Schizophrenia Spectrum Psychosis Completed
  3. Phase 2 Efficacy and Safety of Rifaximin With NAC in IBS-D Completed
  4. Phase 2 Neuroscience-Informed Treatment Development for Adolescent Alcohol Use Completed
  5. Phase 2 Study to Evaluate the Efficacy of N-acetylcysteine (NAC) in the Treatment of the Common Cold and Cough Completed
  6. Phase 2 N-Acetylcysteine for Adolescent Alcohol Use Disorder Completed
  7. Phase 2 Antioxidant Therapy in RYR1-Related Congenital Myopathy Completed
  8. Phase 2 Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio) Completed
  9. Phase 2 Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1 Completed
  10. Phase 2 A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana Completed
  11. Phase 2 A Feasibility Study of N-acetylcysteine for Self-injurious Behavior in Children With Autism Spectrum Disorder Completed
  12. Phase 2 N-Acetylcysteine for Neuroprotection in Parkinson's Disease Completed
  13. Phase 2 N-Acetylcysteine for Pediatric Trichotillomania Completed
  14. Phase 2 Memory and Antioxidants in Vascular Impairment Trial Completed
  15. Phase 2 N-acetylcysteine in the Treatment of PTSD and Addiction Completed
  16. Phase 2 Oral N-acetylcysteine for Protection of Human Nevi Against UV-induced Oxidative Stress/Damage in Vivo Completed
  17. Phase 2 An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents Completed
  18. Phase 2 N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder Completed
  19. Phase 2 Modulation of Lung Injury Complicating Lung Resection Completed
  20. Phase 2 A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders Completed
  21. Phase 2 Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly Completed
  22. Phase 2 NAC for Treating Comorbid PTSD and SUD Completed
  23. Phase 2 N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study) Completed
  24. Phase 2 N-acetylcysteine Treatment of Alcohol Use Disorder In Veterans With TBI Completed
  25. Phase 2 N-acetylcysteine in Alcohol Dependence Completed
  26. Phase 2 Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics Completed
  27. Phase 2 A Study to Assess the Safety and Tolerability of N-Acetylcysteine When Administered With Pirfenidone to Participants With Idiopathic Pulmonary Fibrosis (IPF) Completed
  28. Phase 1 n-Acetylcysteine and Cocaine Completed
  29. Phase 1 Hypertrophic Regression With N-Acetylcysteine in HCM Completed
  30. Phase 1 Bioequivalence Study of Two Different Formulations of N-acetyl-cysteine (NAC) Completed
  31. Phase 1 Intravenous N-acetylcysteine for the Treatment of Gaucher's Disease and Parkinson's Disease Completed
  32. N/A Effect of Long-term, High-dose N-acetylcysteine on Exacerbations of Bronchiectaisis Completed
  33. N/A Effect of the Anti-oxidant N-acetylcysteine on Beta-cell Function in Type 2 Diabetes Completed

Showing the 39 most-cited and recently-updated of 39 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Bismuth quadruple and concomitant regimens achieve >85% H. pylori eradication amid rising clarithromycin resistance
Gastroenterology Sys. Review
Bismuth quadruple and concomitant regimens achieve >85% H. pylori eradication amid rising clarithromycin resistance H. pylori treatments failing as resistance grows, review finds
This narrative review synthesizes current H. pylori eradication strategies, noting that clarithromycin resistance exceeds 15%-20% in most re…
Clarithromycin resistance now tops 15-20% in most regions, but bismuth quadruple and other combos still clear the bug over 85% of the time.
Frontiers Jul 29, 2026
Low-dose N-acetylcysteine reduces acute exacerbation risk in patients with chronic obstructive pulmonary disease
Pulmonology & Critical Care Meta-analysis
Low-dose N-acetylcysteine reduces acute exacerbation risk in patients with chronic obstructive pulmonary disease N-acetylcysteine may reduce flare ups for people with COPD
This meta-analysis of randomized controlled trials involving 2,856 patients found that low-dose N-acetylcysteine (≤600 mg/day) significantly…
A specific dose of N-acetylcysteine could help lower the risk of sudden breathing problems for people living with chronic obstructive pulmon…
Jul 20, 2026
Expert consensus guidelines for N-acetylcysteine use in various respiratory conditions
Rheumatology Guideline
Expert consensus guidelines for N-acetylcysteine use in various respiratory conditions Experts share new guidance on using N-acetylcysteine for lung health
This expert consensus guideline reviews the clinical utility of N-acetylcysteine (NAC) across several respiratory diseases. The authors sugg…
Medical experts have reached a consensus on how a specific supplement might help people managing various chronic lung diseases.
Frontiers May 4, 2026
Oxidative stress drives steroid-induced necrosis of femoral head; antioxidants may help maintain redox balance
Orthopedics & Sports Medicine Sys. Review
Oxidative stress drives steroid-induced necrosis of femoral head; antioxidants may help maintain redox balance Why Steroid Pills Can Quietly Starve Your Hip Bone
This systematic review examined the role of oxidative stress and various antioxidant classes in steroid-induced necrosis of the femoral head…
Steroid pills used for asthma and lupus may quietly starve hip bones of blood through oxidative stress, potentially leading to bone death an…
Frontiers Apr 13, 2026
N-acetylcysteine protocol study for early-onset preeclampsia progression in Lagos, Nigeria
OB/GYN & Women's Health RCT
N-acetylcysteine protocol study for early-onset preeclampsia progression in Lagos, Nigeria NAC study protocol for early-onset preeclampsia in Lagos hospitals planned for 2026 to 2028
This study protocol outlines a planned proof-of-concept trial evaluating daily oral N-acetylcysteine versus placebo in sexually active women…
A planned 2026 trial in Lagos hospitals will test if a daily antioxidant tablet slows the progression of early-onset preeclampsia in pregnan…
medRxiv Apr 9, 2026
High-dose atorvastatin reduces contrast-induced acute kidney injury after coronary angiography in Egyptian patients
Radiology & Imaging RCT
High-dose atorvastatin reduces contrast-induced acute kidney injury after coronary angiography in Egyptian patients Can a common cholesterol drug protect kidneys during heart imaging?
A randomized controlled trial of 120 Egyptian patients undergoing elective coronary angiography found that adding high-dose atorvastatin (80…
A common cholesterol drug cut kidney injury risk in half compared to fluids alone during heart imaging tests.
Apr 3, 2026