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Home › Conditions › Iron Deficiency Anemia

Iron Deficiency Anemia

Part of Anemia

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Iron Deficiency Anemia

42 trials tracked for Iron Deficiency Anemia: 31 in phase 3 or 4 and 13 with published results. The most-cited published study has 290 citations.

42Trials tracked
31Phase 3 & 4
0Recruiting
13With published results
Phase distribution
Phase 4 8 Phase 3 23 Phase 2 4 Phase 1 1 Other / NA 6
  1. Phase 3 Incidence of Hypophosphatemia After Treatment With Iron Isomaltoside/Ferric Derisomaltose or Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia Completed · 290 cited
  2. Phase 3 Incidence of Hypophosphatemia After Treatment With Iron Isomaltoside/Ferric Derisomaltose vs Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia Completed · 289 cited
  3. Phase 3 A Phase III Safety Study of Ferumoxytol Compared to Ferric Carboxymaltose for the Treatment of Iron Deficiency Anemia (IDA) Completed · 193 cited
  4. Phase 4 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed · 142 cited
  5. Phase 3 Iron Isomaltoside/Ferric Derisomaltose vs Iron Sucrose for the Treatment of Iron Deficiency Anemia (IDA) Completed · 109 cited
  6. Phase 3 Iron Isomaltoside/Ferric Derisomaltose vs Iron Sucrose for Treatment of Iron Deficiency Anemia in Non-Dialysis-Dependent Chronic Kidney Disease Completed · 101 cited
Show 36 more trials
  1. Phase 3 A Trial Comparing Ferumoxytol With Iron Sucrose for the Treatment of Iron Deficiency Anemia Completed · 79 cited
  2. Phase 3 A Trial Comparing Ferumoxytol With Placebo for the Treatment of Iron Deficiency Anemia Completed · 76 cited
  3. Phase 3 Study With Oral Ferric Maltol for the Treatment of Iron Deficiency Anemia in Subjects With Chronic Kidney Disease Completed · 37 cited
  4. Phase 4 Intravenous Iron vs. Oral Iron Supplementation for Postpartum Anemia Completed · 14 cited
  5. Phase 3 Daily vs. Every Other Day Oral Iron Supplementation in Patients With Absolute Iron Deficiency Anemia Completed · 9 cited
  6. Phase 3 A Trial of Ferumoxytol for the Episodic Treatment of Iron Deficiency Anemia Completed · 9 cited
  7. Phase 3 Comparison of Oral Ferrous Sulfate to Intravenous Ferumoxytol in Antepartum Iron Deficiency Anemia Completed
  8. Phase 4 KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial) Completed
  9. Phase 4 Alternate Day Versus Daily Oral Iron Therapy in Adolescents Completed
  10. Phase 4 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed
  11. Phase 4 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed
  12. Phase 4 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed
  13. Phase 4 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed
  14. Phase 3 Safety and Efficacy Study of Oral Ferric Maltol Compared to Intravenous Iron To Treat Iron Deficiency Anaemia in IBD Completed
  15. Phase 3 An Extension Trial to Assess the Safety of Re-dosing of Iron Isomaltoside/Ferric Derisomaltose (Monofer®/Monoferric®) Completed
  16. Phase 3 To Assess the Impact of Ferric Carboxymaltose Compared With Iron Sucrose in Chinese Subjects on Correcting Iron Deficiency Anaemia Completed
  17. Phase 3 Efficacy and Safety of Intravenous Ferric Carboxymaltose in Pediatric Patients With Iron Deficiency Anemia and Unsatisfactory Response Oral Iron Under Study Protocol 1VIT17044 Completed
  18. Phase 3 Multicenter Randomized Active-controlled Study to Investigate Efficacy & Safety of IV FCM in Pediatric Patients With IDA Completed
  19. Phase 3 Oral Iron Versus Oral Iron Plus a Web-based Behavioral Intervention in Young Children (IRONCHILD) Completed
  20. Phase 3 Ferric Citrate for the Prevention of Renal Failure in Adults With Advanced Chronic Kidney Disease Completed
  21. Phase 3 Efficacy and Safety of Intravenous Ferric Carboxymaltose (FCM) in Patients With Iron Deficiency Anemia (IDA) Completed
  22. Phase 3 Iron Isomaltoside 1000 (Monofer®) in Non-Dialysis Dependent Chronic Kidney Disease and With Renal-Related Anaemia Completed
  23. Phase 3 A Double-blind, Double-dummy, Parallel, Active-controlled, Randomized Trial to Evaluate Efficacy & Safety in Anemia Subjects Completed
  24. Phase 3 Evaluation of Efficacy and Safety of Ferric Carboxymaltose (FCM) in Patients With Iron Deficiency Anemia and Impaired Renal Function Completed
  25. Phase 3 2 Doses of Ferrlecit Versus Oral Iron to Treat Iron-deficiency Anemia in Peritoneal Dialysis Patients. Completed
  26. Phase 2 Pilot Study: Randomized, Placebo-controlled Comparator Trial of IV vs Oral Iron Treatment of RLS With IDA. (IVOR-IDA) Completed
  27. Phase 2 Ferric Citrate in Managing Serum Phosphorus and Iron Deficiency in Anemic Chronic Kidney Disease (CKD) Subjects Not on Dialysis Completed
  28. Phase 2 Intravenous Ferric Carboxymaltose vs IV Iron Sucrose or IV Iron Dextran in Treating Iron Deficiency Anemia in Women Completed
  29. Phase 2 Hypophosphatemia With Ferric Carboxymaltose Vs. Iron Dextran in Iron Deficiency Secondary to Heavy Uterine Bleeding Completed
  30. Phase 1 Four-Way Crossover Study to Compare Ferric Maltol Capsules and Oral Suspension in Healthy Volunteers Completed
  31. N/A Universal Screening for Tuberculosis and Anemia With the CHICA System Completed
  32. N/A Feraccru® Real World Effectiveness Study in Hospital Practice ( FRESH ) Completed
  33. N/A Does a Daily Iron Tablet Improve Anemia in Cystic Fibrosis Completed
  34. N/A Total Dose Infusion of Ferumoxytol(1020mg) in 15 Minutes for Iron Deficiency Anemia Completed
  35. N/A Trial Comparing Iron Supplementation Versus Routine Iron Intake in Very Low Birth Weight Infants Completed
  36. N/A Bloodsafe Ghana- Iron and Nutritional Counseling Strategy Pilot Study Completed

Showing the 42 most-cited and recently-updated of 42 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Iron Deficiency Anemia: what the trials found

Several iron-based interventions demonstrated significant improvements in hemoglobin (Hb) levels for patients with anemia. Elemental iron showed a statistically significant increase in Hb concentration over time 1. Ferumoxytol was associated with significant increases in Hb concentrations at various time points [14, 15, 17] and showed a median Hb increase of 11.45 units post-intervention 20. Additionally, ferric maltol demonstrated a statistically significant increase in Hb concentration from baseline to week 16 16.

Iron isomaltoside/ferric derisomaltose was associated with significant increases in Hb concentrations at several intervals (weeks 1, 2, 4, and 8) [12, 13]. However, this intervention showed a significantly higher incidence of hypophosphatemia compared to the comparator group across multiple studies [9, 10]. Ferric carboxymaltose resulted in significant increases in both ferritin levels and transferrin saturation (TSAT) from baseline to day 35 22, although the change in Hb concentration was not statistically significant 22.

Other iron preparations showed varying results. Ferrous sulfate was evaluated for changes in ferritin, serum iron, and TSAT at 12 weeks 18. Ferric citrate did not show a statistically significant difference in the composite endpoint of initiation of maintenance dialysis or all-cause mortality 19.

For the clinician treating this condition

  • Ferumoxytol is associated with significant increases in hemoglobin levels and improved fatigue scores in patients with anemia [14, 15, 17].
  • Iron isomaltoside/ferric derisomaltose effectively increases hemoglobin concentration but is associated with a significantly higher risk of hypophosphatemia compared to other treatments [9, 10, 12, 13].
  • Ferric carboxymaltose demonstrates significant improvements in ferritin and TSAT levels 22.

AI synthesis of 6 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Expert consensus recommends universal screening and oral iron therapy for pediatric iron deficiency anemia
Emergency Medicine Guideline
Expert consensus recommends universal screening and oral iron therapy for pediatric iron deficiency anemia Experts set new standards for treating iron deficiency in children
This consensus statement from 14 experts addresses the management of iron deficiency anemia in infants and young children in the MENA region…
New guidelines target high rates of iron deficiency anemia in infants and young children across the Middle East and North Africa.
Frontiers Aug 8, 2026
Probiotics improve hematologic parameters in Chinese children with iron deficiency anemia
Pediatrics Meta-analysis
Probiotics improve hematologic parameters in Chinese children with iron deficiency anemia Probiotics show promise for iron deficiency anemia in children
This meta-analysis of 1,342 patients found that probiotics improved hemoglobin (MD 8.64 g/L) and other hematologic markers in Chinese childr…
New data suggests that probiotics could help manage iron levels and blood health in children struggling with iron deficiency anemia.
Frontiers Aug 7, 2026
Bismuth quadruple and concomitant regimens achieve >85% H. pylori eradication amid rising clarithromycin resistance
Gastroenterology Sys. Review
Bismuth quadruple and concomitant regimens achieve >85% H. pylori eradication amid rising clarithromycin resistance H. pylori treatments failing as resistance grows, review finds
This narrative review synthesizes current H. pylori eradication strategies, noting that clarithromycin resistance exceeds 15%-20% in most re…
Clarithromycin resistance now tops 15-20% in most regions, but bismuth quadruple and other combos still clear the bug over 85% of the time.
Frontiers Jul 29, 2026
Endoscopic investigation for iron deficiency anemia reveals 52.0% prevalence of normal upper gastrointestinal findings
Gastroenterology Meta-analysis
Endoscopic investigation for iron deficiency anemia reveals 52.0% prevalence of normal upper gastrointestinal findings Understanding the Common Findings in Endoscopy for Patients with Iron Deficiency
This meta-analysis of 9,807 adults with confirmed iron deficiency anemia (IDA) evaluated the prevalence of gastrointestinal findings during …
Doctors use endoscopy to find the cause of low iron. This study shows what common issues are found during these tests.
Jul 1, 2026
Systematic review and meta-analysis of liposomal iron versus conventional iron in pediatric iron deficiency anemia
Pediatrics Meta-analysis
Systematic review and meta-analysis of liposomal iron versus conventional iron in pediatric iron deficiency anemia Liposomal iron improves blood counts and reduces side effects in children with anemia
This systematic review and meta-analysis evaluated liposomal iron versus conventional oral iron in 454 children with iron deficiency anemia …
A meta-analysis found liposomal iron raised hemoglobin more and caused fewer side effects than conventional iron in children.
May 25, 2026
Iron micronutrient powders reduce malaria-induced anaemia but not growth in young children
Nutrition & Obesity Medicine RCT
Iron micronutrient powders reduce malaria-induced anaemia but not growth in young children Iron powders reduce malaria-related anaemia in young children
This cluster-randomized trial in 1,806 Ghanaian children aged 6-35 months found that daily iron-containing micronutrient powders for five mo…
Daily iron-based micronutrient powders can lower the risk of malaria-induced anaemia in preschool children in Ghana.
medRxiv Apr 27, 2026
Video capsule endoscopy in children shows diagnostic yield for Crohn's disease but requires endoscopic placement
Pediatrics Cohort
Video capsule endoscopy in children shows diagnostic yield for Crohn's disease but requires endoscopic placement Tiny Camera Spots Crohn's Damage That Scans Miss in Kids
A retrospective single-center study of 60 children undergoing 76 VCE examinations found VCE supported new Crohn's diagnosis in 46% of cases …
A tiny swallowed camera found gut inflammation missed by standard scans in children with Crohn's disease, changing treatment plans for more …
Frontiers Apr 16, 2026
Meta-analysis links lower Fe, Zn, Mg and higher Cu levels to iron deficiency anemia in children
Pediatrics Meta-analysis
Meta-analysis links lower Fe, Zn, Mg and higher Cu levels to iron deficiency anemia in children Children with iron deficiency anemia often have different levels of other minerals in their blood
A systematic review and meta-analysis of 1105 children and adolescents found iron deficiency anemia (IDA) was associated with significantly …
Children with iron deficiency anemia often have lower zinc and magnesium but higher copper levels in their blood.
Apr 2, 2026

Research across Anemia

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Prebiotics, probiotics, and synbiotics do not provide clinically important benefits on hemoglobin or ferritin in children
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