Press needle and plum-blossom needle combination significantly lowers pro-inflammatory cytokines in diabetic peripheral neuropathy
Acupuncture Techniques May Improve Nerve Function in Diabetic Patients
This randomized controlled trial of 225 patients with diabetic peripheral neuropathy found that press needle embedding combined with plum-bl…
A new trial suggests that specific acupuncture techniques may lower inflammation and improve nerve conduction in people with diabetic periph…
Higher Triglyceride-glucose index is associated with increased risk of diabetic peripheral neuropathy
High Triglyceride and Glucose Levels Linked to Nerve Damage in Diabetes
This meta-analysis of 32,281 patients with Type 2 Diabetes found that a higher TyG index is associated with an increased risk of diabetic pe…
High levels of fats and sugars in the blood can significantly increase the risk of nerve damage for people with type 2 diabetes.
Moxibustion Combination Therapies Improve Nerve Conduction and Clinical Scores in Diabetic Neuropathy
Moxibustion combinations may improve nerve function in diabetic neuropathy
A network meta-analysis suggests moxibustion combined with herbal medicine or acupuncture may improve nerve conduction and clinical scores i…
Combining moxibustion with herbal medicine or acupuncture may improve nerve conduction and scores for people with diabetic peripheral neurop…
Pharmacist-led medication therapy management improves adherence and glycemic control in a patient with complex T2DM
Pharmacist-led care improves blood sugar for woman with long-term diabetes
This case report describes a single patient with type 2 diabetes who received pharmacist-led medication therapy management. The intervention…
A pharmacist-led review helped a woman with a 30-year history of Type 2 Diabetes significantly improve her medication adherence and blood su…
Intravenous alpha-lipoic acid optimizes symptom relief while oral administration supports structural repair in DPN
Different ways to give alpha-lipoic acid help diabetic nerve pain
This Bayesian network meta-analysis evaluates various alpha-lipoic acid (ALA) administration routes for diabetic peripheral neuropathy. Find…
New data shows that intravenous and oral versions of alpha-lipoic acid offer different benefits for managing symptoms and repairing nerves i…
Microvascular alteration is a statistically significant determinant for diabetic peripheral neuropathy prevalence
New data reveals key drivers of nerve damage in diabetes
This meta-analysis of 83,560 patients across 24 countries identified a global diabetic peripheral neuropathy (DPN) prevalence of 57.42% (95%…
Over half of people with diabetes suffer from nerve damage, but new data highlights specific blood vessel changes as a primary driver of the…
Nerve decompressive surgery of the lower limbs reduces pain scores in patients with diabetic peripheral neuropathy
Nerve surgery may reduce pain for patients with diabetic neuropathy
This meta-analysis of 7 trials involving 207 patients found that nerve decompressive surgery of the lower limbs (NDSLL) significantly reduce…
New analysis shows nerve decompression surgery can lower pain scores for some people with diabetic peripheral neuropathy.
Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
New research explores how inflammation drives nerve damage in diabetes
This narrative review explores the pathophysiology of diabetic peripheral neuropathy, focusing on how hyperglycemia, lipotoxicity, and intes…
Chronic high blood sugar causes more than just high glucose; it triggers a cycle of inflammation and immune stress that damages nerves.
Exosomes show promise as biomarkers and therapeutic vectors in diabetic complications
Review suggests exosomes may help target multiple diabetes complications
This narrative review explores the role of exosomes in diabetic kidney disease, retinopathy, and peripheral neuropathy. It highlights their …
A narrative review suggests exosomes might inform strategies to target multiple diabetes complications together, though clinical standardiza…
Pregabalin 300 or 600 mg/day significantly reduces pain in painful diabetic peripheral neuropathy versus placebo
Higher doses of pregabalin helped reduce pain scores for people with painful diabetic nerve problems compared to placebo
This randomized controlled trial enrolled 729 patients with painful diabetic peripheral neuropathy. Pregabalin doses of 300 mg/day and 600 m…
A study found that taking 300 or 600 mg of pregabalin daily lowered pain scores better than a fake pill. Lower doses did not work as well fo…
Cross-Sectional Analysis of Protective Foot Sensation and Complications in 387 Type 2 Diabetes Patients
Smoking and kidney disease link to worse diabetes nerve damage in feet
This retrospective cross-sectional study evaluated 387 patients with Type 2 diabetes and Diabetic Peripheral Neuropathy at University Hospit…
Smoking and severe kidney disease greatly increase the risk of losing protective feeling in the feet, leading to dangerous complications for…
Research across Diabetes
Related studies from across the Diabetes family.
DEKODE platform protocol aims to improve clinical and process outcomes in diabetic ketoacidosis
New Digital System Aims to Improve Diabetic Ketoacidosis Care
This guideline outlines a study protocol for the DEKODE platform, a cloud-based audit-and-feedback system for managing diabetic ketoacidosis…
A new digital audit system aims to standardize care and improve outcomes for patients experiencing diabetic ketoacidosis in hospital setting…
SGLT2 inhibitors reduce risk of diabetic retinopathy progression (rr 0.77) and macular edema progression (rr 0.75)
SGLT2 inhibitors show promise in slowing diabetic eye disease
This meta-analysis of 1,785,409 patients with established diabetic retinopathy (DR) or diabetic macular edema (DME) found that SGLT2i therap…
A large analysis suggests SGLT2 inhibitors may slow the progression of vision-threatening complications in people with diabetes.
Mass spectrometry identifies 681 differentially expressed proteins in patients with proliferative diabetic retinopathy
Proteomics Analysis Identifies Key Proteins in Diabetic Retinopathy
This meta-analysis of proteomics data using mass spectrometry identified 681 differentially expressed proteins in patients with proliferativ…
New research identifies specific proteins and biological pathways linked to proliferative diabetic retinopathy to help guide future medical …
rs741301 polymorphism is associated with reduced susceptibility to diabetic nephropathy in meta-analysis
Genetic Marker Linked to Lower Risk of Diabetic Kidney Disease
This meta-analysis of 880 individuals with diabetes mellitus and 1008 individuals with diabetic nephropathy found that the rs741301 polymorp…
A specific genetic variation, known as the rs741301 polymorphism, may be linked to a lower risk of developing kidney damage in people with d…
Ranibizumab port delivery system shows noninferior BCVA gains and low supplemental treatment requirements in diabetic retinopathy
Ranibizumab port delivery system shows promise for diabetic eye conditions
This meta-analysis evaluates the ranibizumab port delivery system (PDS) for patients with diabetic retinopathy and diabetic macular edema. T…
A new delivery system for ranibizumab shows consistent results for patients with diabetic retinopathy and macular edema.
Invasive spinal cord stimulation provides variable relief across diverse chronic neuropathic pain conditions
Different types of spinal cord stimulation help various chronic pains
This narrative review synthesizes evidence on invasive spinal cord stimulation (SCS) for various neurological and pain conditions. The autho…
Newer forms of spinal cord stimulation offer promising relief for complex nerve pain and failed back surgeries, but results vary by conditio…
Euonymus alatus may improve glucose metabolism and reduce urinary protein in diabetic nephropathy
Plant extract shows promise in managing diabetes and kidney health
This systematic review of preclinical and clinical data indicates that Euonymus alatus may lower blood glucose, reduce urinary protein, and …
A review of the plant Euonymus alatus suggests it may lower blood sugar and protect kidneys in people with diabetes.
Spinal cord stimulation with medical management reduces pain intensity in painful diabetic neuropathy
Spinal Cord Stimulation Shows Promise for Diabetic Neuropathy Pain
This meta-analysis of adults with painful diabetic neuropathy found that spinal cord stimulation combined with conventional medical manageme…
Adding spinal cord stimulation to standard medical care may significantly reduce pain intensity for adults living with painful diabetic neur…
AI-OCT reports reduced false-positive DME referral rates from 69.1% to 24.1%
AI technology reduces unnecessary referrals for diabetic macular edema
This randomized clinical trial evaluated the impact of AI-OCT reports on identifying diabetic macular edema (DME) in patients with diabetes.…
New research shows that adding AI-powered imaging can significantly cut down on false alarms when screening patients for eye issues caused b…
Vitamin D supplementation shows low certainty reductions in urinary markers for diabetic kidney disease
Vitamin D shows limited benefit for diabetic kidney disease
This umbrella review meta-analysis evaluates vitamin D and its analogs in patients with diabetic kidney disease. While some reduction in uri…
Vitamin D may lower protein in urine for diabetic kidney disease, but evidence is weak and no benefit for kidney function or survival.
Balanced crystalloids reduce time to DKA resolution by 1.60 hours compared to 0.9% saline
Balanced Crystalloids May Speed Recovery in Pediatric Diabetic Ketoacidosis
This meta-analysis of 320 pediatric patients with diabetic ketoacidosis found that balanced crystalloids significantly reduced the time to D…
A review of data suggests balanced crystalloid fluids may resolve diabetic ketoacidosis faster than standard saline in children.
Early subcutaneous basal insulin plus IV insulin reduces time to DKA resolution by 4.06 hours
Early Subcutaneous Insulin Shortens Recovery Time for Diabetic Ketoacidosis
This meta-analysis of randomized controlled trials evaluated adding early subcutaneous basal insulin to intravenous insulin for adults with …
Adding early subcutaneous insulin to IV treatment can speed up recovery for patients with diabetic ketoacidosis without increasing safety ri…
Questions about Diabetic Peripheral Neuropathy
Can pregabalin effectively lower pain levels in patients with Diabetic Peripheral Neuropathy?
Yes, pregabalin at 300 or 600 mg/day significantly reduces pain in painful diabetic peripheral neuropathy, though duloxetine may be slightly more effective and gabapentin less so.
Full answer →Is there a link between foot sensation and complications in Diabetic Peripheral Neuropathy?
A loss of protective sensation in the feet is linked to more severe clinical complications, such as ulcers and amputations, in patients with diabetic peripheral neuropathy.
Full answer →Does nerve decompressive surgery reduce pain for those with Diabetic Peripheral Neuropathy?
Nerve decompressive surgery can reduce pain in diabetic peripheral neuropathy, but evidence is mixed and limited by study quality; discuss risks and benefits with your doctor.
Full answer →