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Home › Medications › vitamin C

vitamin C

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of vitamin C

9 trials tracked of vitamin C: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 291 citations.

9Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 3 Phase 2 5 Other / NA 1
  1. Phase 3 Vitamin C, Thiamine, and Steroids in Sepsis Completed · 291 cited
  2. Phase 3 Vitamin C and Septic Shock Completed · 65 cited
  3. Phase 3 Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures Completed
  4. Phase 2 Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis Completed
  5. Phase 2 A Phase Ib Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations Completed
  6. Phase 2 Vitamin C in Atrial Fibrillation Ablation Completed
Show 3 more trials
  1. Phase 2 High Dose Vitamin C Intravenous Infusion in Patients With Resectable or Metastatic Solid Tumor Malignancies Completed
  2. Phase 2 Vitamin C & Thiamine to Treat Sepsis and Septic Shock Completed
  3. N/A Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Completed

Showing the 9 most-cited and recently-updated of 9 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Intravenous Vitamin C Administration in Severe Burn Patients Shows Potential Harm
Drug Pipeline RCT
Intravenous Vitamin C Administration in Severe Burn Patients Shows Potential Harm Trial shows intravenous vitamin C may harm patients with severe burns
A Phase 3 trial indicates that high-dose intravenous vitamin C may increase mortality and organ dysfunction in severe burn patients.
A large clinical trial suggests that high-dose intravenous vitamin C may increase mortality rates in patients with severe burn injuries.
JAMA Sep 21, 2026
Intravenous vitamin C associated with reduced mortality in patients with sepsis and septic shock
Nutrition & Obesity Medicine Meta-analysis
Intravenous vitamin C associated with reduced mortality in patients with sepsis and septic shock Vitamin C May Reduce Mortality in Patients with Sepsis
This meta-analysis evaluated the impact of intravenous vitamin C on outcomes for patients with sepsis or septic shock. The authors observed …
A review of data suggests intravenous vitamin C may lower death rates for patients with sepsis, though the evidence quality remains low.
Frontiers Sep 7, 2026
Preoperative nutritional management and micronutrient supplementation show mixed results for colorectal cancer patients
Dermatology Sys. Review
Preoperative nutritional management and micronutrient supplementation show mixed results for colorectal cancer patients Nutritional supplements show mixed results for colorectal cancer surgery
This mini review examines the impact of preoperative nutritional management, including immunonutrition and micronutrient supplementation, on…
Malnourished colorectal cancer patients face higher complication risks, but supplement evidence is mixed.
Frontiers Aug 29, 2026
Intravaginal vitamin C may increase short-term cure and prevent recurrence of bacterial vaginosis
Infectious Disease Meta-analysis
Intravaginal vitamin C may increase short-term cure and prevent recurrence of bacterial vaginosis Intravaginal Vitamin C May Help Treat Bacterial Vaginosis in Nonpregnant Patients
A meta-analysis of 1,107 nonpregnant patients found intravaginal vitamin C (250 mg daily for 6 days) was associated with higher short-term c…
Intravaginal vitamin C cured 66% of bacterial vaginosis patients in short-term trials, outperforming placebo and showing promise against sta…
Apr 9, 2026