N/A N=36 Brain Function and Decision-Making
Behavior, Social · Psychology, Social · Social Interaction
Primary: Change in Prefrontal Cortex Brain Activity Assessed by fMRI — -0.002; 0.015 Percent BOLD Signal Change
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=18 Brain Markers of Improvements in Cognitive Functioning
TBI (Traumatic Brain Injury) · Brain Injuries · Stress
Primary: Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery — 0.18; -0.06 units on a scale
N/A N=35 Neural Bases of Cognitive Rehabilitation for Brain Injury
Brain Injury
Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score
N/A N=122 Exercise Effects on Brain Health and Learning From Minutes to Months
Sedentary Lifestyle
Primary: Change in Hippocampal-dependent Learning — -.00369; .00404 learning rate (proportion correct/trial) — p=<.05
N/A N=76 Neural Basis of Sensory and Motor Learning: Functional Connections
Basic Science
Primary: Resting-state PMv-M1 Functional Connectivity (Fisher Z-transformed Correlation) — 0.64 unitless (Fisher z-score)
Phase 2 N=30 The Efficient Brain Study
Metabolism - Cerebral Energy
Primary: Magnetic Resonance Spectroscopy (MRS) Will Measure a Change in Cerebral Energy Function in Brain Tissue — .011; .007; .009; .006 Difference in metabolite amplitude
N/A N=20 Aerobic Exercise to Improve Executive Language Function In Older Adults
Aging
Primary: Executive Language Functions — 31.6; 30.8; 33.7; 31.8 Mean outpoint by group at pre and post
N/A N=49 Cognitive Dysfunction in Parkinson's Disease
Parkinson's Disease
Primary: Change in Magnetoencephalography (MEG) Connectivity Measures
N/A N=16 Neural Underpinnings of Turning
Aging
Primary: Duration of Cortical Silent Period (CSP) (ms) — 104.34; 99.71 milliseconds (ms)
Phase 2 N=54 Brain Function and Structure in Cocaine Dependence
Cocaine Dependence
Primary: Cocaine Use/Treatment Effectiveness Score (TES) — 6.6; 8.3; 29 percentage of negative urines
N/A N=108 Brain Training to Enhance Frontal Lobe Reasoning
Traumatic Brain Injury
Primary: Glasgow Outcome Scale-Extended — 6.21; 6.30 units on a scale
N/A N=39 Theta Connectivity in Working Memory
Executive Function
Primary: Number of Remembered Items — 1.72; 1.68; 1.68; 1.65 remembered items — p=0.783
Phase 4 N=61 Neurocognitive Benefits of a Weight Management Program
Overweight and Obesity
Primary: Blood Oxygen Level-dependent (BOLD) Response to High-calorie Foods Cues Minus Neutral Objects in Left Anterior Cingulate Cortex — -0.05; -0.16 percent BOLD signal change
N/A N=26 Brain Stimulation and Enhancing Cognition in Older Adults
Cognitive Impairment, Mild · Depressive Symptoms · Anxiety
Primary: Cognitive and Memory Function — 56.5; 49.8 score on a scale
N/A N=15 Brain Stimulation and Cognitive Training - Efficacy
Schizophrenia · Schizo Affective Disorder · Bipolar Disorder
Primary: Change in Working Memory Performance - Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB)…
N/A N=24 Effects of Acetate and Alcohol on Brain Function
Cerebral Blood Flow · Brain Function
Primary: Change in Cerebral Blood Flow as Measured With Arterial Spin Labeling — 31.7; 26.9; 30.0; 25.0 cc/100 mg/min
N/A N=130 Exercise, Brain, and Cardiovascular Health
Cardiovascular Diseases
Primary: Change in Hippocampal Volume — -15.4; -49.9 mm^3
N/A N=95 Cognitive Dysfunction In Parkinson's
Parkinson's
Primary: Differences in Error Rates on the NBack Task Between Real and Sham Stimulation Trials — -0.79; -0.1 incorrect responses
Phase 2 N=38 Aging and Estrogen on Cortical Function
Memory Loss · Cognitive Changes · Postmenopausal Symptoms
Primary: Functional Magnetic Resonance Imaging (fMRI) Changes in Response to Estrogen and Aging - Dorsolateral Pre-frontal Cortex (DLPFC) — 455.8; -214.4; -348.1; 90.1 linear…
N/A N=93 Neuroplasticity in TBI and Schizophrenia
Schizophrenia · Traumatic Brain Injury
Primary: Mismatch Negativity (MMN) Amplitudes in Microvolts — -0.59; -1.19; -0.41; -0.65 microvolts
N/A N=42 Added Sugar Intake and Brain Structure and Function
Child Development
Primary: Added Sugars Intake Relationship to Brain Structure — 0.119; -0.231; 0.345; 0.384 Pearson correlation coefficient
Early Phase 1 N=138 Drugs Brain and Behavior (DDP)
Stimulant Use
Primary: Change in SUbjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Sub-scales of Drug Effects Questionnaire (DEQ). — 19.2; 57.8…
Phase 2 N=40 Metformin Effect on Brain Function in Insulin Resistant Elderly People
Insulin Resistance · Obesity · Obesity, Abdominal
Primary: Change From Baseline in Brain PCr/ATP Ratio as Measured by Phosphorus Magnetic Spectroscopy (31P-MRS) After 10 Months of Metformin Administration — -0.045; -0.016…
N/A N=180 MINDSpeed Food and Brain Training RCT
Low Education · Cognition · Cognitive Training
Primary: Executive Cognitive Function Composite Score — 0.211; 0.100; 0.142; 0.196 units on a scale
N/A N=22 Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Change From Baseline in California Verbal Learning Task Score — 3.04; 5.17; 4.22; 7.04 score on a scale
N/A N=12 Brain Stimulation and Cognitive Training
Bipolar Disorder · Schizo Affective Disorder · Schizophrenia
Primary: Participant Retention in Combination Treatment — 4; 5 Participants
N/A N=78 The Effect of Acute Concurrent Exercise on Executive Function: An Event-Related Potential Study
Executive Function
Primary: Task Switch Test Response Times — 783.97; 788.76; 839.46; 566.46 millisecond
N/A N=12 The Effect of Transcranial Direct Current Stimulation on Human Brains: A Neuroimaging Study
Chronic Schizophrenia
Primary: Cognition on the RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) Scale — 7; 5.25; -1.5; -1.33 units on a scale
Phase 2 N=73 Cognitive Stimulation
Substance Use Disorders
Primary: Working Memory — 0.86; 0.04 digits recalled
N/A N=30 Triglyceride Effects on Blood Flow in the Human Brain
Alzheimer Disease
Primary: Cerebral Blood Flow Global — -2.2 ml/100g/min — p=.002