Clinical Trial Search

Primary: Fear and Avoidance of Memory Loss (FAM) Scale Score at Follow-up — 63.9; 60.3 score on a scale

Primary: Delay Eyeblink Conditioning — 52.32; 56.88 percentage of conditioned responses

Primary: Change From Baseline of the Score Number Relative to the Self-efficacy Factor, Consisting of Average Scores on the Domains Capacity, Control and Change of the…

Primary: MDT Change in Mnemonic Discrimination — 0.09; 0.01 LDI score on a scale — p== 0.016

Primary: Link Between Lack of Word and Presbycusis — 38; 38.5; 23; 21.5 score on a scale

Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items

Primary: PWMC Loneliness — 4.90; 5.28 units on a scale

Primary: Brain Activity in the Dentate Gyrus / CA3 Subregion of the Hippocampus Measured With Blood Oxygenation Level Dependent (BOLD) Functional MRI — -0.1203; 0.4353; -0.2238…

Primary: Change in East Boston Memory Test Scores From Baseline to 24 Weeks, 48 Weeks, and 72 Weeks — 0.03; -0.02; 0.01; 0.05 score on a scale — p=.409

Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score

Primary: Quality of Life in Alzheimer's Disease (QOL-AD)--Participants With Dementia (PWD) — 35.42; 38.10; 35.56; 36.12 score on a scale

Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized

Primary: California Verbal Learning Test II — 6.9; 6.2; 6.46; 5.10 units on a scale — p=0.048

Primary: 15-Item Word List Delayed Recall — -0.3; -0.5 units on a scale - change from baseline — p=<.05

Primary: Everyday Memory Failures — 0.55; 0.62 average daily number memory failures/day — p=.67

Primary: Explicit Memory Performance — 1.16; .51; 1.04; .98 units on a scale

Primary: Change in Total Recall Score in the Selective Reminding Test — 5.7; 9.4 score on a scale — p=0.05

Primary: Hopkins Verbal Learning Test-Revised (HVLT-R) — 23.52; 20.04; 23.68; 20.39 score on a scale

Primary: fMRI Measure of Hippocampal Activation — 36.4; 41.3 percentage of active voxels

Primary: Cognitive Scores at Baseline and Week 12 — 96; 99; 101; 103 score on a scale

Primary: Rey Auditory Verbal Learning Test (RAVLT) — 51.89; 45.90; 48.37 T-scores — p=0.003

Primary: ADAS-Cog-Exec Global Composite — -0.146; -0.068 Change score — p=0.29

Primary: Number of Confabulations — 30.0; 29.9; 8.1; 35.5 Confabulations

Primary: Changes in Prefrontal Cortex Brain Activation at 6 Months — 90.64; -62.20; 28.07; -79.04 beta-weight

Primary: Change in Center for Epidemiological Studies Depression Scale (CES-D) From Baseline — 7.04; 6.09 score on a scale — p=0.020

Primary: Cognitive Measures - Hopkins Verbal Learning Test (HVLT) Total Recall Score — 26.02; 25.76; 27.96; 28.81 units on a scale

Primary: Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment — 80.0; 62.45 percent correct — p=<.001

Primary: Overnight Change in Declarative Memory Performance — 11.2; 6.5 percent change in performance

Primary: Auditory Memory Attention Index — 89.0; 94.3 standard score units — p=<0.01

Primary: Frequency of Agitated and Aggressive Behaviors (Staff Report) — 50.31; 48.04 score on scale — p=< 0.05