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Chemotherapy-induced neutropenia

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for chemotherapy-induced neutropenia

9 trials tracked for chemotherapy-induced neutropenia: 6 in phase 3 or 4 and 4 with published results. The most-cited published study has 37 citations.

9Trials tracked
6Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 3 6 Phase 2 2 Other / NA 1
  1. Phase 3 Phase III Study Comparing the Efficacy and Safety of LA-EP2006 and Neulasta® Completed · 37 cited
  2. Phase 3 Plinabulin vs. Pegfilgrastim in Patients With Solid Tumors Receiving Docetaxel Myelosuppressive Chemotherapy Phase 3 Completed · 31 cited
  3. Phase 3 Neugranin in Breast Cancer Participants Receiving Doxorubicin/Docetaxel Completed · 26 cited
  4. Phase 3 Phase III Study Comparing the Efficacy and Safety of LA-EP2006 and Peg-Filgrastim Completed · 14 cited
  5. Phase 3 Study of the Efficacy and Safety of Empegfilgrastim for Neutropenia Prophylaxis in Breast Cancer Patients Completed
  6. Phase 3 Balugrastim (Neugranin) in Breast Cancer Participants Receiving Doxorubicin/Docetaxel Completed
Show 3 more trials
  1. Phase 2 Plinabulin vs. Pegfilgrastim in Patients With Solid Tumors Receiving Docetaxel Myelosuppressive Chemotherapy Phase 2 Completed
  2. Phase 2 Dose-finding Study of Empegfilgrastim for Neutropenia Prophylaxis in Patients With Breast Cancer Completed
  3. N/A Feasibility of Monitoring Health Data in Pediatric Patients Undergoing Chemotherapy Completed

Showing the 9 most-cited and recently-updated of 9 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Chemotherapy-induced neutropenia: what the trials found

Clinical trials have evaluated several interventions for managing chemotherapy-induced neutropenia. LA-EP2006 was assessed in two Phase 3 trials, which reported mean durations of severe neutropenia (DSN) during Cycle 1 as 0.75 to 0.83 days 1 and 1.19 to 1.36 days 4. Correspondingly, the time to ANC recovery in Cycle 1 was recorded at 1.58 to 1.72 days 1 and 2.04 to 2.11 days 4.

Empegfilrastim (6 mg) was evaluated in a Phase 3 trial where the incidence of severe neutropenia (Grade 3-4) was recorded at 34, 40, and 40 across study arms 6. This trial also measured the duration of Grade 4 neutropenia; during Cycle 1, durations were reported as 0.791, 0.905, and 1.725 days 6, while from the 2nd to 4th cycle (Week 12), durations ranged from 0.244 to 0.925 days 6.

Other interventions evaluated in Phase 3 trials for this condition include Neugranin 3 and Balugrastim 5. Additionally, Plinabulin was assessed in a Phase 3 trial where results included changes in estimated mean bone pain scores of 1.69 and 2.35, and the proportion of patients with a neutrophil-to-lymphocyte ratio (NLR) > 5 was recorded as 2 and 24 2. Plinabulin was also evaluated in a Phase 2 trial 7.

Recent results — preliminary, needs further review

  • Empegfilrastim showed a reduction in CTCAE Grade 3/4 neutropenia incidence (11, 13, 18; p<0.05) and mean duration of Grade 4 neutropenia (0.33, 0.40, 0.43) in a Phase 2 study 8.
  • Everion was evaluated in a non-specified phase trial 9.

For the clinician treating this condition

  • LA-EP2006 is associated with specific mean durations of severe neutropenia and defined times to ANC recovery during the first cycle of chemotherapy [1, 4].
  • Empegfilrastim (6 mg) data provides specific metrics on the incidence and duration of Grade 3-4 and Grade 4 neutropenia across multiple cycles 6.
  • Plinabulin was evaluated in both Phase 2 and Phase 3 trials, with Phase 3 data specifically noting bone pain scores and neutrophil-to-lymphocyte ratios [2, 7].

AI synthesis of 9 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.