Arthritis

All Arthritis Articles

• Febuxostat lowers serum urate but renal function declines in UMOD-related kidney disease
• Autoimmune comorbidities recur with MS, but evidence cannot define a prodrome or distinct subgroups
• Distinct immune mechanisms and myeloid-cell activation differentiate systemic juvenile idiopathic arthritis from adult rheumatoid arthritis
• Protocol targets host-response biomarker accuracy for PJI in inflammatory arthritis
• Dietary patterns and nutritional interventions may modify risk and inflammation in rheumatoid arthritis
• Monocyte and macrophage sensing of calciprotein particles triggers inflammasome activation and interleukin-1β release
• PRP shows limited structural benefit in knee osteoarthritis, with patellofemoral cartilage and bone marrow edema signals
• Immune and chondrocyte ligand-receptor axes drive osteoarthritis progression and offer therapeutic targets
• Alcohol consumption is associated with a 1.809 odds ratio for gout and hyperuricemia risk
• IL-5/IL-5Rα blockade provides clinically validated benefit in EGPA but requires phenotype-specific evidence for other conditions
• Telitacicept Shows Satisfactory Response in Complex Overlap Syndrome Case
• Macrophage-fibroblast interactions drive inflammatory amplification and cartilage-degrading enzyme production in osteoarthritis
• RAAS inhibitors modulate inflammatory responses and oxidative stress across multiple chronic conditions
• Telemedicine May Improve Pain and Function in Arthritis Patients
• Metabolic stress from obesity and hyperglycemia impairs macrophage efferocytosis in osteoarthritis joint environments
• Non-steroidal anti-inflammatory drugs are a predictably effective first-line pharmacologic therapy for canine osteoarthritis
• Vigorous activity and regular exercise are associated with lower psoriasis prevalence in patients with psoriasis
• DMARD withdrawal significantly increases disease flare risk in patients with rheumatoid arthritis
• Patient education combined with exercise reduces pain in knee osteoarthritis patients by MD -3.28
• Cementless mobile-bearing UKA shows noninferior survivorship and clinical scores to cemented devices
• Kinematic vs Mechanical Alignment in Total Knee Arthroplasty: Similar Outcomes, Higher Preference
• Biologic explanation of gout causes increases belief in long-term medication compared to lifestyle focus
• Yoga significantly improves psychological outcomes and reduces IL-6 levels in patients with rheumatoid arthritis
• Immune-cell activation and metabolic dysfunction may interact to influence synovial inflammation and cartilage homeostasis in osteoarthritis
• Late-onset axial spondyloarthritis cases comprise 13.43% of cases with lower HLA-B27 positivity
• Digital support for exercise improves physical function in knee osteoarthritis patients
• Surgical treatment for tophaceous gout linked to 24% overall complication rate in meta-analysis
• Sickle cell trait is associated with increased risk of kidney disease, pulmonary embolism, and anemia
• Ixekizumab combined with tirzepatide improves disease activity and weight in patients with Psoriatic Arthritis
• Tumor necrosis factor inhibition is associated with improvements in CNS-related outcomes in rheumatoid arthritis
• Ultrasound-guided peripheral nerve blocks provide analgesic benefits for patients with refractory osteoarthritis pain
• Lateral meniscal abnormalities do not significantly impact short- to mid-term outcomes after medial UKA
• Immune cells and bone lineage cells interact via cytokines to modulate bone homeostasis in musculoskeletal disorders
• Interleukin inhibitors in rheumatoid arthritis are associated with increased risk of serious infections and discontinuations
• Multi-omics biomarkers and AI integration offer potential for precision medicine in rheumatoid arthritis
• Knee osteoarthritis research trends show increasing focus on metabolic syndrome and inflammatory signaling
• TCM components sinomenine, icariin, and curcumin modulate macrophage polarization and metabolic pathways in rheumatoid arthritis
• Robot-assisted total hip arthroplasty associated with improved leg-length accuracy and functional scores
• Umbilical cord-derived mesenchymal stromal cells balance immune homeostasis and offer potential for inflammatory disease treatment
• Cardiovascular risk for Janus kinase inhibitors in rheumatoid arthritis remains inconsistent across specific molecules
• Moderate-intensity isotonic exercise improves function by MD -16.66 in patients with knee osteoarthritis
• Coumarins and derivatives may protect musculoskeletal health by modulating inflammatory and oxidative mediators
• Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty
• B-cell targeted therapies show durable immune responses in pemphigus vulgaris and myasthenia gravis
• Deep-learning models show variable sensitivity and precision for knee osteoarthritis grading
• Ozone injections are more effective than corticosteroids for short and medium term pain in knee osteoarthritis
• Opioid-free perioperative regimens associated with lower pain scores and fewer side effects in hip arthroplasty
• HLA-B alleles B*39:01, B*13:01, and B*38:02 serve as markers for sulfasalazine-induced SCARs in Asian populations
• Gut microbiota-targeted interventions reduce pain and function scores in patients with osteoarthritis
• Vunakizumab may induce severe ulcerative colitis and hepatic enzyme elevation in patients with psoriatic arthritis
• Robotic-assisted TKA using functional alignment principles yields favorable outcomes and low early revision risk
• Long Term Clinical Outcomes of Highly Cross-linked Polyethylene in Young Hip Arthroplasty Patients
• Immune signaling and bidirectional neuropeptide release drive nociceptor sensitization in osteoarthritis pain
• ACR20 overestimates treatment effects compared to target-based outcomes in patients with rheumatoid arthritis
• Therapeutic extracellular vesicles may curb inflammation and restore mitochondrial quality in osteoarthritis
• Exercise improves physical function and reduces pain in adults with rheumatoid arthritis
• CDAI and SDAI scores improve prediction of osteoporosis in patients with rheumatoid arthritis
• Platelet-rich plasma, autologous serum, and cyclosporine A show specific benefits in Sjögren's syndrome dry eye
• Skin lesions typically precede spinal arthritis in patients with follicular occlusion triad and spondyloarthritis
• Icariin improves pain and cartilage scores in murine osteoarthritis, meta-analysis finds
• Interactive remote rehabilitation shows no significant advantage over conventional rehabilitation for post-TKA patients
• Caulophyllum robustum extracts show anti-inflammatory and bone protective activity in preclinical models of rheumatoid arthritis
• Multi-trait genome-wide association studies identify 66 novel genetic associations in osteoarthritis using the Trident framework
• Adalimumab significantly improves ACR70 and PASI100 outcomes in patients with psoriatic arthritis
• Inaccessible infrastructure and stigma create significant barriers to WASH access for adults with musculoskeletal disabilities
• Tailor-made DMARD selection based on autoantibody status does not improve DAS scores in RA
• Engineered nanobodies offer programmable platform to overcome limitations of conventional antibodies in angiogenic diseases
• Adalimumab improves axial inflammation in hidradenitis suppurativa with spondyloarthritis features
• Inflammaging and immunosenescence emerge as key mechanistic axes in osteoarthritis pathogenesis
• Exosomes are safe for knee osteoarthritis but show no superiority over placebo in one trial
• CT-based CPAK measurements show more varus MPTA and valgus LDFA than LLR
• Smoking exposure dominates literature on autoimmune inflammatory rheumatic diseases with limited immune-mechanism integration
• Telemedicine modalities may achieve comparable outcomes to conventional follow-up for uncomplicated total joint arthroplasty
• Mechanical loading induces innate immune reprogramming and mitochondrial danger signals in osteoarthritis models
• Ixekizumab Q2W shows highest P-score among IL-17 inhibitors for active psoriatic arthritis
• TCM formulas and monomeric compounds restore macrophage polarization balance in Sjögren's syndrome
• Ion channels and signaling pathways form a mechanobiological-immunological framework for osteoarthritis progression
• No genetic loci reached genome-wide significance for inpatient opioid exposure after joint arthroplasty
• Epigenetic regulation provides a framework for understanding disease heterogeneity and potential precision therapies in osteoarthritis
• Axia smartphone application increases ASAS20 response to 51% in patients with axial spondyloarthritis
• JAK inhibitors maintain efficacy in patients with multiple prior biologic DMARD failures
• Opioids provide clinically important pain relief for short durations but lack long-term efficacy in osteoarthritis
• RA PRO dashboard shows no significant short-term effects on patient decision-making or medication adherence
• Certolizumab pegol dose escalation from 200 mg to 400 mg results in 2-fold increase in plasma concentration
• MDA and ACR20 Best Discriminate Treatment Response in PsA
• Glucocorticoid use and rheumatoid arthritis significantly increase vertebral fracture risk in postmenopausal women
• Infection, instability, and aseptic loosening are the primary causes of revision TKA failure
• Evaluating Biological DMARD Discontinuation versus Dose Reduction in Rheumatoid Arthritis Remission
• JAK inhibitors show 81.7% treatment retention in adult patients with rheumatoid arthritis and interstitial lung disease
• Guselkumab improves ACR20 rates to 58.6% and 62.2% in patients with psoriatic arthritis
• MSC therapy improves salivary flow in Sjögren's animal models, meta-analysis finds
• Minimally invasive fixation of thoracolumbar fractures in ankylosing spondylitis reduces operative time and blood loss
• Crohn disease and ulcerative colitis causally raise ankylosing spondylitis risk
• Medicinal and edible plants offer potential immunomodulatory mechanisms for various autoimmune diseases
• Extracellular vesicles in RA: biomarkers and therapeutic vehicles, but clinical utility remains unproven
• TNF inhibitors may be effective for juvenile idiopathic arthritis in patients with DiGeorge syndrome
• Intensive CV management reduces cIMT progression in RA patients without hepatic steatosis
• VR-assisted physiotherapy improves pain, function, and balance in knee osteoarthritis
• FGF/FGFR signaling systems provide diverse mechanistic targets across multiple systemic autoimmune rheumatic diseases
• Mongolian warm acupuncture improves clinical response in knee osteoarthritis vs oral meds
• Celecoxib ranks highest for analgesic efficacy in patients with knee osteoarthritis
• Subcutaneous methotrexate improves ACR20 response and reduces GI side effects in RA
• Combination therapies with adalimumab, infliximab, tofacitinib, or upadacitinib increase serious infection risk in rheumatoid arthritis
• Extracellular vesicles offer immunomodulatory mechanisms and targeted delivery for potential precision therapies in rheumatoid arthritis
• Metabolic reprogramming of chondrocytes through impaired oxidative phosphorylation contributes to articular cartilage collapse
• Integrated biomarker panels provide more complete insights into mechanism-specific therapeutic responses in rheumatoid arthritis
• Succinate accumulation drives inflammatory and immune dysregulation in rheumatoid arthritis through three distinct pathways
• Structured exercise reduces depressive symptoms and improves quality of life in adults with rheumatoid arthritis
• Neuromodulation techniques show promise for pain and function in knee osteoarthritis, but evidence is low certainty
• Gut microbiota dysbiosis linked to osteoarthritis pathology in preclinical and human studies
• Health literacy is moderately associated with improved self-care behaviors in patients with multiple chronic diseases
• AI models show high correlation with physics-based methods to predict peak knee adduction moment
• Intraoperative surgeon-performed adductor canal blocks are non-inferior to anesthesiologist-performed blocks for TKA discharge
• Genistein shows potential to attenuate inflammation and reduce disease severity in autoimmune conditions
• TENS reduces pain (MD -0.82) and improves muscle strength in patients with knee osteoarthritis
• Second-generation bicruciate-retaining TKA shows 5.7% revision rate in meta-analysis
• Adalimumab and its biosimilar IBI303 show distinct response clusters in ankylosing spondylitis
• Chronic ACL deficiency increases risk of moderate to severe arthritis compared to reconstruction
• Arthroscopic exploration and debridement may resolve pain and restore motion in rice body synovitis
• Evaluating Treat to Target Outcomes in Elderly and Young Rheumatoid Arthritis Patients
• Upadacitinib 15 mg daily achieves DAS28-CRP ≤3.2 in 43.3% of patients versus 22.4% for adalimumab
• Tai Chi and Wuqinxi reduce pain while Pilates and Baduanjin improve physical function in knee osteoarthritis
• Hand-dominant joint involvement patterns associate with better clinical outcomes in early rheumatoid arthritis
• Targeting metabolic checkpoints and mechanotransduction may address structural deterioration in axial spondyloarthritis
• Evaluating the Efficacy of Traditional Chinese Medicine Decoctions for Rheumatoid Arthritis Management
• Peripheral mechanisms like proton-sensing channels and neurovascular remodeling contribute to pain in osteoarthritis
• JAK and IL-6 inhibitors outperform TNF inhibitors for activity limitation in rheumatoid arthritis
• IL-6 blockade causes early lipid increases but maintains cardiovascular neutrality in rheumatoid arthritis
• Hyperuricemia affects 22% of type 2 diabetes patients in global meta-analysis
• Exercise therapy significantly improves pain and physical function in elderly patients with knee osteoarthritis
• Axial psoriatic arthritis is associated with significantly lower HLA-B27 positivity than axial spondyloarthritis
• Circadian misalignment associated with increased risk of osteoporosis, sarcopenia, and osteoarthritis
• Over half of Arab adults with chronic diseases possess high digital health literacy scores
• Probiotics show potential for knee osteoarthritis symptoms but evidence is limited
• Risk-optimized use of Janus kinase inhibitors in Japanese patients with rheumatoid arthritis depends on comorbidities
• Long-term personalized exercise therapy shows potential cost-effectiveness for patients with axial spondyloarthritis
• Gut-joint axis and m6A epigenetic modifications provide a potential mechanism for gout pathophysiology
• NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
• Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
• Short-term prednisolone bridging enables 95% discontinuation in new rheumatoid arthritis patients after 24 months
• Cartilage Thickness Score shows higher values in future knee osteoarthritis cases in a cohort study
• Biologic and targeted synthetic DMARDs show reassuring malignancy safety in inflammatory arthritides, but non-melanoma skin cancer risk rises with TNF inhibitors
• Meta-analysis finds rheumatoid arthritis associated with increased thyroid cancer risk in pooled cohort data
• Large meta-analysis identifies 30 new genetic loci for ankylosing spondylitis risk
• Kinematic alignment improves function and pain over mechanical alignment in robotic TKA
• Patellar resurfacing and nonresurfacing show similar 5-year outcomes in total knee arthroplasty
• Sleep problems affect 61% of adults with rheumatoid arthritis in WHO EMRO countries
• Microbiota-targeted interventions for elderly-onset rheumatoid arthritis remain an area requiring further investigation
• Gut microbiome metabolites regulate bone health via SCFAs, bile acids, and tryptophan pathways
• CD38+ NK cells may link disrupted immune tolerance in rheumatoid arthritis and colorectal cancer
• Review of ruxolitinib for systemic juvenile arthritis with macrophage activation syndrome
• Systematic review and meta-analysis of Wuqinxi for knee osteoarthritis joint function
• Umbrella review suggests curcumin may offer comparable efficacy and better tolerability than NSAIDs for osteoarthritis
• Living systematic review finds low-certainty evidence that stopping csDMARDs before surgery may increase flare risk in inflammatory arthritis
• Meta-analysis of upadacitinib for rheumatoid arthritis finds similar efficacy for 15 mg and 30 mg doses
• Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
• Narrative review discusses CD40/CD40L signaling regulation in rheumatoid arthritis and other autoimmune conditions
• Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
• Systematic review of Dendrobium phenanthrene bioactivity across multiple disease models
• Narrative review explores m6A modification and metabolic reprogramming in rheumatoid arthritis
• Review of neutrophil extracellular traps in patients with gout
• Narrative review on peptidylarginine deiminase 4 and gasdermin inhibition in autoimmune diseases
• Narrative review on multi-omics for spondyloarthritis and psoriatic arthritis
• Systematic review and meta-analysis of herpes zoster risk in rheumatoid arthritis patients
• Narrative review explores plant-derived extracellular vesicles for rheumatoid arthritis
• Systematic review and meta-analysis of olive-derived compounds for osteoarthritis pain
• Vunakizumab improves ASAS20 response in active radiographic axial spondyloarthritis at 16 weeks
• FDA Approves Hadlima (adalimumab) for Multiple Inflammatory Indications
• Telephone-delivered Walk With Ease program recruitment strategies compared in adults with arthritis
• Meta-analysis of 38 rodent studies shows sinomenine reduces arthritis markers in preclinical models
• Treat-to-target strategy improves gout remission vs symptom-driven care
• Psoriatic arthritis linked to interstitial lung disease prevalence
• Targeted therapies for psoriasis and psoriatic arthritis significantly alter lipid profiles across diverse patient populations
• Systematic review explores the role of RNA methylation in autoimmune rheumatic diseases
• Narrative review of transposable element methylation in autoimmune diseases
• Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis
• Team-based care with rheumatological specialist assistants improved patient satisfaction in seropositive rheumatoid arthritis flares
• Systematic review and meta-analysis of diagnostic algorithms for rheumatoid arthritis and juvenile idiopathic arthritis
• High-intensity exercise improves strength and aerobic capacity in rheumatoid arthritis patients compared to low-intensity exercise
• Late-onset rheumatoid arthritis shows higher DAS28 scores and lower remission rates compared to young-onset disease in a meta-analysis
• Systematic review and meta-analysis of supervised exercise for foot pain in rheumatoid arthritis
• Systematic review and meta-analysis supports adalimumab plus methotrexate for JIA-associated uveitis
• Ixekizumab shows efficacy in children with enthesitis-related and juvenile psoriatic arthritis
• Peripheral nerve lesion types in patients with primary Sjögren's syndrome
• GWAS and Mendelian randomization link aging, rheumatoid arthritis, and herpes zoster via shared MHC signals
• Acupuncture and Celecoxib for Chronic Knee Pain: Genetic Factors May Influence Response
• Feasibility Review of Portable Markerless Motion Capture for Knee OA
• Narrative review on macrophage metabolism in gouty arthritis and therapeutic gaps
• Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data
• Systematic review and meta-analysis of stem cell therapy for dry eye in Sjögren's syndrome
• Nomogram Predicts Osteoporosis Risk in Rheumatoid Arthritis Patients
• Combined MSK US and machine learning model improves rheumatoid arthritis disease activity assessment
• Etanercept therapy alters monocyte subsets and improves DAS28-CRP in rheumatoid arthritis patients
• Multi-ancestral GWAS identifies 152 RA loci with improved polygenic risk scores for AFR and AMR populations
• Narrative review explores exosomal non-coding RNAs in osteoarthritis pathogenesis and therapy
• Meta-analysis identifies genetic variants linked to inflammatory pathways in rheumatoid arthritis and axial spondyloarthritis
• Intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious adverse events
• Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions
• Anti-centromere antibody-positive Sjögren's syndrome profile predicted by serologic and clinical factors
• Narrative review discusses screening and prevention in rheumatic and musculoskeletal disease populations