Clozapine Use Linked to Higher SARS-CoV-2 Infection Risk in Severe Mental Disorders
Clozapine users faced higher risk of severe COVID-19 in large study
A meta-analysis of 155,945 outpatients with severe mental disorders found that clozapine users had a higher rate of SARS-CoV-2 infection com…
A massive analysis of over 155,000 people found that those taking clozapine had higher rates of infection and worse outcomes from COVID-19.
Preclinical study characterizes SARS-CoV-2 particles in infected cells and patient nasal swabs using flow virometry.
Lab study finds new way to detect SARS-CoV-2 particles in patient samples
This preclinical research article describes the detection and characterization of single SARS-CoV-2 viral particles. The authors report obse…
A lab study shows a method can detect SARS-CoV-2 particles directly in patient nasal swabs without extra preparation steps.
Narrative review suggests time-related biases may attenuate apparent vaccine survival benefits in cancer patients.
New math shows vaccine benefits in cancer care might be overstated
This narrative review and target trial emulation examines 3-year overall survival in cancer patients receiving COVID-19 vaccines versus thos…
A new look at the data reveals that timing errors made the vaccine look more powerful than it actually is for cancer patients.
Metformin, fluvoxamine, or ivermectin for non-hospitalized COVID-19 adults in a Phase 3 trial
Metformin Cuts Long Covid Risk by 40%
This randomized controlled trial in 1323 non-hospitalized adults with SARS-CoV-2 infection evaluated metformin, fluvoxamine, or ivermectin v…
A common diabetes pill taken early in Covid infection cuts the odds of developing long-term symptoms by 40%, offering new hope for millions.
Nirmatrelvir-ritonavir showed no reduction in hospitalization or death within 28 days for higher-risk adults in community trials.
New Study Questions Early Use of Paxlovid for Vaccinated Patients
In community-based trials involving higher-risk adults with recent SARS-CoV-2 infection, adding nirmatrelvir-ritonavir to usual care did not…
Getting vaccinated changes how your body fights the virus, and this new research shows that taking Paxlovid early might not be necessary for…
Infection status associated with hypoxemia and death rates varying by virus type in a large US cohort.
Triple Virus Infections Rarer Than Feared — Here’s the Real Risk
This cohort study of 835,987 triple-tested patients in the US Veterans Health Administration examined associations between infection status …
It’s winter. Your throat is scratchy. Your chest feels tight.
EBOV-specific gene signature identified in nonhuman primates and human cohorts with Ebola infection
New gene signature can spot Ebola infection in blood samples
This observational cohort study analyzed RNA-Seq data from nonhuman primates and human cohorts with Ebola virus infection and comparator inf…
Researchers found a 50-gene signature that reliably separates Ebola from other infections in blood tests, pointing to a future diagnostic to…
Observational cohort study on SARS-CoV-2 evolution in immunocompromised patients
Long COVID Virus Changes Shape Inside Severely Ill Patients, Study Finds
This observational cohort study analyzed longitudinal SARS-CoV-2 genomes from 91 immunocompromised patients with COVID-19. It found that sev…
When the virus lingers too long in very sick patients, it changes in unpredictable ways, highlighting the need for stronger treatments.
Systematic review synthesizes immune and genetic factors in African SARS-CoV-2 populations
Why Africa saw milder COVID-19
This narrative synthesis reviews 40 studies from African settings regarding SARS-CoV-2 infection. The authors describe widespread pre-existi…
Africa saw milder COVID-19 because unique genes and immune defenses helped people fight the virus without getting severely sick.
Observational study finds COVID-19 mRNA vaccines effective against infection in frontline workers, with reduced protection during Delta spread.
Did COVID vaccines work against infection? Yes, but less so against Delta.
An observational study of frontline workers in eight U.S. locations found COVID-19 mRNA vaccines were effective against SARS-CoV-2 infection…
COVID-19 mRNA vaccines prevent infection in frontline workers, but protection drops as the contagious Delta variant spreads.
CDC reports nearly 10,300 breakthrough COVID-19 infections among 101 million fully vaccinated Americans
How many vaccinated people got COVID? The CDC counted nearly 10,300 cases.
An observational CDC report from January to April 2021 documented approximately 10,300 breakthrough SARS-CoV-2 infections among roughly 101 …
Nearly 10,300 vaccinated people in the U.S. reported getting COVID-19, but this small number shows vaccines still offer strong protection ag…
Suspected recurrent SARS-CoV-2 infections reported among nursing facility residents during second outbreak
Report describes suspected COVID-19 reinfections in a Kentucky nursing home
A facility report from Kentucky described suspected recurrent SARS-CoV-2 infections among skilled nursing facility residents during a second…
A Kentucky nursing home report describes possible SARS-CoV-2 reinfections among residents during a second outbreak in late 2020.